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Drug Absorption with Food

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References

  1. Lennernäs H. Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans. Curr Drug Metab 2007;8:645–657.

    Article  Google Scholar 

  2. Cramer C. Emergency! Hypertensive crisis from drug-food interaction. Am J Nurs 1997;97(5):32.

    Article  CAS  Google Scholar 

  3. Welling PG. Influence of food and diet on gastrointestinal drug absorption: a review. J Pharmacokin Biopharm 1977;5(4):291–334.

    Article  CAS  Google Scholar 

  4. Schmidt LE, Dalhoff K. Food-drug interactions. Drugs 2002;62(10):1481–1502.

    Article  CAS  Google Scholar 

  5. Singh BN. Effects of food on clinical pharmacokinetics. Clin Pharmacokin 1999;37(3):213–255.

    Article  CAS  Google Scholar 

  6. Maka DA, Murphy LK. Drug-nutrient interactions: a review. AACN Clin Issues 2000;11(4):580–589.

    Article  CAS  Google Scholar 

  7. Jarosz M, Dzieniszewski J. [Interactions between food and drugs. 1. Malabsorption]. Polski Merkuriusz Lekarski 2000;9(53): 791–794.

    CAS  Google Scholar 

  8. Fuhr U. [Clinically significant” new drug interactions]. Medizinische Klinik 2000;95(1 Spec No):18–22.

    CAS  Google Scholar 

  9. Fleisher D, Li C, Zhou Y, et al. Drug, meal and formulation interactions influencing drug absorption after oral administration: clinical implications. Clin Pharmacokin 1999;36(3):233–254.

    Article  CAS  Google Scholar 

  10. Brown RO, Dickerson RN. Drug-nutrient interactions. Am J Manag Care 1999;5(3):345–352.

    CAS  Google Scholar 

  11. Evans AM. Influence of dietary components on the gastrointestinal metabolism and transport of drugs. Ther Drug Monit 2000;22:131–136.

    Article  CAS  Google Scholar 

  12. Singh BN, Malhotra BK. Effects of food on the clinical pharmacokinetics of anticancer agents: underlying mechanisms and implications for oral chemotherapy. Clin Pharmacokinet 2004;43:1127–1156.

    Article  CAS  Google Scholar 

  13. Dressman JB, Thelen K, Jantratid E. Towards quantitative prediction of oral drug absorption. Clin Pharmacokinet 2008;47:655–667.

    Google Scholar 

  14. Amidon GL, Lennernas H, Shah VP, et al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 1995;12(3):413–420.

    Article  CAS  Google Scholar 

  15. Custodio JM, Wu C-Y, Benet LZ. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Adv Drug Delivery Rev 2008;60:717–733.

    Article  CAS  Google Scholar 

  16. Abrahamsson B, Lennernäs H. Application of the biopharmaceutic classification system now and in the future. In: van de Waterbeemd H, Testa B, eds. Drug bioavailability: estimation of solubility, permeability, absorption and bioavailability, 2nd edition. Weinheim, Germany: Wiley-VCH, 2009:523–558.

    Google Scholar 

  17. Knupp CA, Shyu WC, Morgenthien EA, et al. Biopharmaceutics of didanosine in humans and in a model for acid-labile drugs, the pentagastrin-pretreated dog. Pharm Res 1993;10(8):1157–1164.

    Article  CAS  Google Scholar 

  18. Perry CM, Noble S. Saquinavir soft-gel capsule formulation: review of its use in patients with HIV infection. Drugs 1998;55(Mar):461–486.

    Article  CAS  Google Scholar 

  19. Gidal BE, Maly MM, Budde J, et al. Effect of a high-protein meal on gabapentin pharmacokinetics. Epilep Res 1996;23(1):71–76.

    Article  CAS  Google Scholar 

  20. Nimmo WS. Gastric emptying and drug absorption. Pharm Int 1980;1(Nov):221–223.

    CAS  Google Scholar 

  21. Li C, Fleisher D, Li L, et al. Regional-dependent intestinal absorption and meal composition effects on systemic availability of LY303366, a lipopeptide antifungal agent, in dogs. J Pharm Sci 2001;90:47–57.

    Google Scholar 

  22. Jonkman JH. Food interactions with sustained-release theophylline preparations. A review Clin Pharmacokin 1989;16(3):162–179.

    Article  CAS  Google Scholar 

  23. Abrahamsson B, Alpsten M, Bake B, et al. Drug absorption from nifedipine hydrophilic matrix extended-release (ER) tablet-comparison with an osmotic pump tablet and effect of food. J Cntrl Rel 1998;52(3):301–310.

    Article  CAS  Google Scholar 

  24. Schug BS, Brendel E, Wolf D, et al. Formulation-dependent food effects demonstrated for nifedipine modified-release preparations marketed in the European Union. Eur J Pharm Sci 2002;15(3):279–285.

    Article  CAS  Google Scholar 

  25. Hendeles L, Weinberger M, Milavetz G, et al. Food-induced “dose-dumping” from a once-a-day theophylline product as a cause of theophylline toxicity. Chest 1985;87(6):758–765.

    Article  CAS  Google Scholar 

  26. Meyer JH, Dressman J, Fink A, et al. Effect of size and density on canine gastric emptying of nondigestible solids. Gastroenterology 1985;89(4):805–813.

    CAS  Google Scholar 

  27. Jadcherla SR, Berseth CL. Effect of erythromycin on gastroduodenal contractile activity in developing neonates. J Ped Gastroenterol Nutr 2002;34(1):16–22.

    Article  Google Scholar 

  28. Walsh JH, Dockray GJ, eds. Gut peptides. In: Martini L. ed. Comprehensive Endocrinology. New York: Raven Press, 1994.

    Google Scholar 

  29. Choe SY, Neudeck BL, Welage LS, et al. Novel method to assess gastric emptying in humans: the Pellet Gastric Emptying Test. Eur J Pharm Sci 2001;14(4):347–353.

    Article  CAS  Google Scholar 

  30. Mojaverian P, Rocci ML Jr., Conner DP, et al. Effect of food on the absorption of enteric-coated aspirin: correlation with gastric residence time. Clin Pharmacol Ther 1987;41(1):11–17.

    Article  CAS  Google Scholar 

  31. Yu LX, Crison JR, Amidon GL. Compartmental transit and dispersion model analysis of small intestinal transit flow in humans. Int J Pharm 1996;140(Aug 16):111–118.

    Article  CAS  Google Scholar 

  32. Kondo Y, Torii K, Itoh Z, et al. Erythromycin and its derivatives with motilin-like biological activities inhibit the specific binding of 125I-motilin to duodenal muscle. Biochem Biophys Res Comm 1988;150(2):877–882.

    Article  CAS  Google Scholar 

  33. Sarna SK, Condon RE. Morphine-initiated migrating myoelectric complexes in the fed state in dogs. Gastroenterology 1984;86(4):662–669.

    CAS  Google Scholar 

  34. Koch KM, Parr AF, Tomlinson JJ, et al. Effect of sodium acid pyrophosphate on ranitidine bioavailability and gastrointestinal transit time. Pharm Res 1993;10(7):1027–1030.

    Article  CAS  Google Scholar 

  35. Lewis SJ, Heaton KW, Oakey RE, et al. Lower serum oestrogen concentrations associated with faster intestinal transit. Br J Canc 1997;76(3):395–400.

    Article  CAS  Google Scholar 

  36. Oberle RL, Chen, TS, Lloyd C, et al. The influence of the interdigestive migrating myoelectric complex on the gastric emptying of liquids. Gastroenterology 1990;99(5):1275–1282.

    CAS  Google Scholar 

  37. Hunt JN. Does calcium mediate slowing of gastric emptying by fat in humans? Am J Physiol 1983;244(1):G89–G94.

    CAS  Google Scholar 

  38. Jansen JB, Fried M, Hopman WP, et al. Relation between gastric emptying of albumin-dextrose meals and cholecystokinin release in man. Dig Dis Sci 1994;39(3):571–576.

    Article  CAS  Google Scholar 

  39. Glatzle J, Kalogeris TJ, Zittel TT, et al. Chylomicron components mediate intestinal lipid-induced inhibition of gastric motor function. Am J Physiol 2002;G282(1).

    Google Scholar 

  40. Lin HC, Doty JE, Reedy TJ, et al. Inhibition of gastric emptying by glucose depends on length of intestine exposed to nutrient. Am J Physiol 1989;256(2 Pt 1):G404–G411.

    CAS  Google Scholar 

  41. Lin HC, Doty JE, Reedy TJ, et al. Inhibition of gastric emptying by sodium oleate depends on length of intestine exposed to nutrient. Am J Physiol 1990;259(6 Pt 1):G1031–G1036.

    CAS  Google Scholar 

  42. Schirra J, Katschinski M, Weidmann C, et al. Gastric emptying and release of incretin hormones after glucose ingestion in humans. J Clin Invest 1996;97(1):92–103.

    Article  CAS  Google Scholar 

  43. Yamazaki A, Kumagai Y, Fujita T, et al. Different effects of light food on pharmacokinetics and pharmacodynamics of three benzodiazepines, quazepam, nitrazepam and diazepam. J Clin Pharm Ther 2007;32:31–39.

    Article  CAS  Google Scholar 

  44. Chen YX, Cabana B, Kivel N, Michaelis A. Effect of food on the pharmacokinetics of rifalazil, a novel antibacterial, in healthy male volunteers. J Clin Pharmacol 2007;47:841–849.

    Article  CAS  Google Scholar 

  45. Raybould HE, Zittel TT, Holzer HH, et al. Gastroduodenal sensory mechanisms and CCK in inhibition of gastric emptying in response to a meal. Dig Dis Sci 1994;39(12 Suppl):41S–43S.

    Article  CAS  Google Scholar 

  46. Lu HH, Thomas JD, Tukker JJ, et al. Intestinal water and solute absorption studies: comparison of in situ perfusion with chronic isolated loops in rats. Pharm Res 1992;9(Jul):894–900.

    Article  CAS  Google Scholar 

  47. Vidon N, Pfeiffer A, Franchisseur C, et al. Effect of different caloric loads in human jejunum on meal-stimulated and nonstimulated biliopancreatic secretion. Am J Clin Nutr 1988;47(3):400–405.

    CAS  Google Scholar 

  48. Persson EM, Nilsson RG, Hansson GI, et al. A clinical single-pass perfusion investigation of the dynamic in vivo secretory response to a dietary meal in human proximal small intestine. Pharm Res 2006;23:742–751.

    Article  CAS  Google Scholar 

  49. Persson EM, Gustafsson AS, Carlsson AS, et al. The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids. Pharm Res 2005;22:2141–2151.

    Article  CAS  Google Scholar 

  50. Lu HH, Thomas J, Fleisher D. Influence of D-glucose-induced water absorption on rat jejunal uptake of two passively absorbed drugs. J Pharm Sci 1992;81(Jan):21–25.

    Article  CAS  Google Scholar 

  51. Piyapolrungroj N, Li C, Bockbrader H, et al. Mucosal uptake of gabapentin (neurontin) vs. pregabalin in the small intestine. Pharm Res 2001;18(8):1126–1130.

    Article  CAS  Google Scholar 

  52. Reppas C, Meyer JH, Sirois PJ, et al. Effect of hydroxypropylmethylcellulose on gastrointestinal transit and luminal viscosity in dogs. Gastroenterology 1991;100(5 Pt 1):1217–1223.

    CAS  Google Scholar 

  53. Horter D, Dressman JB. Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. Adv Drug Deliv Rev 2001;46(1–3):75–87.

    Article  CAS  Google Scholar 

  54. Stevenson CM, Radulovic LL, Bockbrader HN, et al. Contrasting nutrient effects on the plasma levels of an amino acid-like antiepileptic agent from jejunal administration in dogs. J Pharm Sci 1997;86(8):953–957.

    Article  CAS  Google Scholar 

  55. Forbes JA, Sandberg RA, Bood-Bjorklund L. The effect of food on bromfenac, naproxen sodium, and acetaminophen in postoperative pain after orthopedic surgery. Pharmacotherapy 1998;18(3):492–503.

    CAS  Google Scholar 

  56. Carver PL, Fleisher D, Zhou SY, et al. Meal composition effects on the oral bioavailability of indinavir in HIV-infected patients. Pharm Res 1999;16(May):718–724.

    Article  CAS  Google Scholar 

  57. Jezyk NLC, Stewart BH, Wu X, et al. Transport of pregabalin in rat intestine and caco-2 monolayers. Pharm Res 1999;16(4):519–526.

    Article  CAS  Google Scholar 

  58. Poiger H, Schlatter C. Interaction of cations and chelators with the intestinal absorption of tetracycline. Naun Schmied Arch Pharmacol 1979;306(1):89–92.

    Article  CAS  Google Scholar 

  59. Fleisher D, Sheth N, Kou JH. Phenytoin interaction with enteral feedings administered through nasogastric tubes. JPEN 1990;14(5):513–516.

    CAS  Google Scholar 

  60. Penrod LE, Allen JB, Cabacungan LR. Warfarin resistance and enteral feedings: 2 case reports and a supporting in vitro study. Arch Phys MedRehab 2001;82(9):1270–1273.

    Article  CAS  Google Scholar 

  61. Ameer B, Weintraub RA. Drug interactions with grapefruit juice. Clin Pharmacokinet 1997;33(2):103–121.

    Article  CAS  Google Scholar 

  62. Edgar B, Bailey D, Bergstrand R, et al. Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine – and its potential clinical relevance. Eur J Clin Pharmacol 1992;42(3):313–317.

    Article  CAS  Google Scholar 

  63. Chen L, Mohr SN, Yang CS. Decrease of plasma and urinary oxidative metabolites of acetaminophen after consumption of watercress by human volunteers. Clin Pharmacol Ther 1996;60(6):651–660.

    Article  CAS  Google Scholar 

  64. Paine MF, Leung LY, Lim HK, et al. Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion. J Pharmacol Exp Ther 2002;301(1):174–186.

    Article  CAS  Google Scholar 

  65. Kirby BJ, Unadkat JD. Grapefruit juice, a glass full of drug interactions? Clin Pharmacol Ther 2007;81:631–633.

    Article  CAS  Google Scholar 

  66. Schmiedlin-Ren P, Edwards DJ, Fitzsimmons ME, et al. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. Drug Metab Dispos 1997;25(11):1228–1233.

    CAS  Google Scholar 

  67. Lown KS, Bailey DG, Fontana RJ, et al. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression. J Clin Invest 1997;99(10):2545–2553.

    Article  CAS  Google Scholar 

  68. Mohri K, Uesawa Y, Sagawa K. Effects of long-term grapefruit juice ingestion on nifedipine pharmacokinetics: induction of rat hepatic P-450 by grapefruit juice. Drug Metab Dispos 2000;28(4):482–486.

    CAS  Google Scholar 

  69. Lu X, Li C, Fleisher D. Cimetidine sulfoxidation in small intestinal microsomes. Drug Metab Dispos 1998;26(9):940–942.

    CAS  Google Scholar 

  70. Okerholm RA, Chan KY, Lang JF, et al. Biotransformation and pharmacokinetic overview of enoximone and its sulfoxide metabolite. Am J Cardiol 1987;60(5):21C-26C.

    Article  CAS  Google Scholar 

  71. Kim RB, Fromm MF, Wandel C, et al. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 1998;101(2):289–294.

    Article  CAS  Google Scholar 

  72. Fontana RJ, Lown KS, Paine MF, et al. Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers. Gastroenterology 1999;117(1):89–98.

    Article  CAS  Google Scholar 

  73. Lo YL, Huang JD. Comparison of effects of natural or artificial rodent diet on etoposide absorption in rats. In Vivo 1999;13(1):51–55.

    CAS  Google Scholar 

  74. Mueller EA, Kovarik JM, vanBree JB, et al. Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulation. Pharm Res 1994;11(1):151–155.

    Article  CAS  Google Scholar 

  75. Saitoh H, Aungst BJ. Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine. Pharm Res 1995;12(9):1304–1310.

    Article  CAS  Google Scholar 

  76. Guo A, Marinaro W, Hu P, et al. Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos 2002;30(4):457–463.

    Article  CAS  Google Scholar 

  77. Piyapolrungroj N, Zhou YS, Li C, et al. Cimetidine absorption and elimination in rat small intestine. Drug Metab Dispos 2000;28(1):65–72.

    CAS  Google Scholar 

  78. Wacher VJ, Salphati L, Benet LZ. Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Deliv Rev 2001;46(1–3):89–102.

    Article  CAS  Google Scholar 

  79. Hochman JH, Chiba M, Nishime J, et al. Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4. J Pharmacol Exp Ther 2000;292(1):310–318.

    CAS  Google Scholar 

  80. Li LY, Amidon GL, Kim JS, et al. Intestinal metabolism promotes regional differences in apical uptake of indinavir: coupled effect of P-glycoprotein and cytochrome P450 3A on indinavir membrane permeability in rat. J Pharmaco Exp Ther 2002;301(2):586–593.

    Article  CAS  Google Scholar 

  81. Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302(2):645–650.

    Article  CAS  Google Scholar 

  82. Eagling VA, Profit L, Back DJ. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol 1999;48(4):543–552.

    Article  CAS  Google Scholar 

  83. Stevenson CM, Kim J, Fleisher D. Colonic absorption of antiepileptic agents. Epilepsia 1997;38(1):63–67.

    Article  CAS  Google Scholar 

  84. Hsyu PH, Pritchard JF, Bozigian HP, et al. Comparison of the pharmacokinetics of an ondansetron solution (8 mg) when administered intravenously, orally, to the colon, and to the rectum. Pharm Res 1994;11(1):156–159.

    Article  CAS  Google Scholar 

  85. Barr WH, Zola EM, Candler EL, et al. Differential absorption of amoxicillin from the human small and large intestine. Clin Pharmacol Ther 1994;56(3):279–285.

    Article  CAS  Google Scholar 

  86. Li C, Fleisher D, Li L, et al. Regional-dependent intestinal absorption and meal composition effects on systemic availability of LY303366, a lipopeptide antifungal agent, in dogs. J Pharm Sci 2001;90(Jan):47–57.

    Article  CAS  Google Scholar 

  87. Powell DW. Barrier function of epithelia. Am J Physiol 1981;241(4):G275–G288.

    CAS  Google Scholar 

  88. Krugliak P, Hollander D, Schlaepfer CC, et al. Mechanisms and sites of mannitol permeability of small and large intestine in the rat. Dig Dis Sci 1994;39(4):796–801.

    Article  CAS  Google Scholar 

  89. Kinugasa T, Sakaguchi T, Gu X, et al. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 2000;118(6):1001–1011.

    Article  CAS  Google Scholar 

  90. Pao LH, Zhou SY, Cook C, et al. Reduced systemic availability of an antiarrhythmic drug, bidisomide, with meal co-administration: relationship with region-dependent intestinal absorption. Pharm Res 1998;15(2):221–227.

    Article  CAS  Google Scholar 

  91. Kenyon CJ, Brown F, McClelland GR, et al. The use of pharmacoscintigraphy to elucidate food effects observed with a novel protease inhibitor (saquinavir). Pharm Res 1998;15(3):417–422.

    Article  CAS  Google Scholar 

  92. Yeh KC, Deutsch PJ, Haddix H, et al. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents Chemother 1998;42(2):332–338.

    CAS  Google Scholar 

  93. Li LY, Stewart BH, Fleisher D. Oral delivery of HIV-protease inhibitors. Crit Rev Ther Drug Carrier Syst 2000;17(2):73–99.

    Google Scholar 

  94. Physicians' Desk Reference, 63rd edition. Montvale, NJ: Thomson Healthcare, 2009.

    Google Scholar 

  95. www.fda.gov/cder/guidance/3618fnl.htm. Waiver of In-vivo Bioavailability and Bioequivalence Studies for Immediate -Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System, 2000.

  96. Welling PG, Lyons LL, Craig WA, et al. Influence of diet and fluid on bioavailability of theophylline. Clin Pharmacol Ther 1975;17(4):475–480.

    CAS  Google Scholar 

  97. Melander A, Danielson K, Schersten B, et al. Enhancement of the bioavailability of propranolol and metoprolol by food. Clin Pharmacol Ther 1977;22(1):108–112.

    CAS  Google Scholar 

  98. Levy RH, Pitlick WH, Troupin AS, et al. Pharmacokinetics of carbamazepine in normal man. Clin Pharmacol Ther 1975;17(6):657–668.

    CAS  Google Scholar 

  99. Williams RL, Mordenti J, Upton RA, et al. Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products. Pharm Res 1987;4(4):348–352.

    Article  Google Scholar 

  100. www.fda.gov/cder/guidance/5356fnl.htm. Bioavailability and Bioequivalence Studies for Orally Administered Drug Products – General Considerations, 2003.

  101. Code of Federal Regulations, 21 CFR 320.25 (f) (ii).

    Google Scholar 

  102. Skelly JP, Barr WH, Benet LZ, et al. Report of the workshop on Controlled-Release Dosage Forms: issues and Controversies. Pharm Res 1987;4(1):75–77.

    Article  Google Scholar 

  103. Skelly JP, Amidon GL, Barr WH, et al. In Vitro and In Vivo Testing and Correlation for Oral Controlled/Modified-Release Dosage Forms. Pharm Res 1990;7(9):975–982.

    Article  Google Scholar 

  104. www.fda.gov/cder/guidance/5194fnl.htm. Food Effect Bioavailability and Fed Bioequivalence Studies, 2002.

  105. www.fda.gov/cder/guidance/3616fnl.htm, Statistical Approaches to Establishing Bioequivalence, 2001.

  106. www.fda.gov/cder/foi/label, 2008.

  107. Gu C-H, Li H, Levons J, et al. Predicting effect of food on extent of drug absorption based on physicochemical properties. Pharm Res 2007;24:1118–1130.

    Google Scholar 

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Fleisher, D., Sweet, B.V., Parekh, A., Boullata, J.I. (2009). Drug Absorption with Food. In: Boullata, J., Armenti, V. (eds) Handbook of Drug-Nutrient Interactions. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-60327-362-6_8

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