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Influence of Protein-Calorie Malnutrition on Medication

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References

  1. Torún B. Protein-energy malnutrition. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, eds. Modern Nutrition in Health and Disease, 10th ed. Philadelphia, PA: Lipppincott Williams & Wilkins, 2006:881–908.

    Google Scholar 

  2. Oyelami OA, Ogunlesi TA. Kwashiorkor- is it a dying disease? SAMJ 2007;97(1):65–68.

    CAS  Google Scholar 

  3. Centers for Disease Control and Prevention. Overweight and obesity. Updated Mar 2008. http://www.cdc.gov/nccdphp/dnpa/obesity/index.htm. Accessed April 14, 2008.

  4. Victora CG, Kirkwood BR, Ashworth A, Black RE, Rogers S, Sazawal S, Campbell H, Gove S. Potential interventions for the prevention of childhood pneumonia in developing countries: improving nutrition. Am J Clin Nutr 1999;70:309–320.

    CAS  Google Scholar 

  5. Gross R, Webb P. Wasting time for wasted children: severe child undernutrition must be resolved in non-emergency settings. Lancet 2006;367:1209–1211.

    Article  Google Scholar 

  6. DeNavas-Walt C, Proctor BD, Smith J. U.S. Census Bureau, Current Population Reports, P60–233. Income, poverty, and health insurance coverage in the United States, 2006. Washington, DC: U.S. Government Printing Office, 2007.

    Google Scholar 

  7. Onyango AW, de Onis M, Caroli M, Shah U, Sguassero Y, Redondo N, Carroli B. Field-testing the WHO child growth standards in four countries. J Nutr 2007;137(1):149–52.

    CAS  Google Scholar 

  8. Schofield C, Ashworth A. Why have mortality rates for severe malnutrition remained so high? Bull World Health Organ 1996;74:223–229.

    CAS  Google Scholar 

  9. Adebami OJ, Oyedeji GA, Owa JA, Oyelami OA. Maternal factors in the etiology of fetal malnutrition in Nigeria. Pediatr Int 2007;49(2):150–152.

    Article  Google Scholar 

  10. Gupta P, Ray M, Dua T, Radhakrishnan G, Kumar R, Sachdev HPS. Multimicronutrient supplementation for undernourished pregnant women and the birth size of their offspring. Arch Pediatr Adolesc Med 2007;161:58–64.

    Article  Google Scholar 

  11. de Onis M, Onyango AW, Borghi E, Garza C, Yang H, WHO Multicentre Growth Reference Study Group. Comparison of the World Health Organization (WHO) Child Growth Standards and the National Center for Health Statistics/WHO international growth reference: implications for child health programmes. Public Health Nutr. 2006 Oct;9(7):942–7.

    Google Scholar 

  12. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 2006;295:1549–1555.

    Article  CAS  Google Scholar 

  13. Hamwi GJ. Therapy: changing dietary concepts. In:Danowski TS, ed. Diabetes mellitus: diagnosis and treatment. New York: Am Diabet Assoc, 1964:73–78.

    Google Scholar 

  14. Devine BJ. Gentamicin therapy. Drug Intell Clin Pharm 1974;8:650–655.

    Google Scholar 

  15. Boullata JI. Influence of obesity on drug disposition and effect. In:Boullata JI, Armenti VT, eds. Handbook of drug-nutrient interactions. Totowa, NJ: Humana Press Inc., 2004:101–126.

    Google Scholar 

  16. Rolfes SR, Pinna K, Whitney E. Understanding Normal and Clinical Nutrition,  7th ed. Wadsworth, OH: West/Wadsworth 2006.

    Google Scholar 

  17. Studley HO. Percentage of weight loss: a basic indicator of surgical risk in patients with chronic peptic ulcer. JAMA 1936;106:458–459.

    Google Scholar 

  18. Detsky AS, McLaughlin JR, Baker JP. What is subjective global assessment of nutritional status? J Parenter Enteral Nutr 1987;11:8–13.

    Article  CAS  Google Scholar 

  19. Covinsky KE, Martin GE, Beyth RJ, Justice AC, Sehgal AR, Landefeld CS. The relationship between clinical assessments of nutritional status and adverse outcomes in older hospitalized medical patients. J Am Geriatr Soc 1999;47:532–538.

    CAS  Google Scholar 

  20. Regazzi MB, Rondanelli R, Calvi M. The need for pharmacokinetics protocols in special cases. Pharmacol Res 1993;27:21–32.

    Article  CAS  Google Scholar 

  21. Renton KW. Alteration of drug biotransformation and elimination during infection and inflammation. Pharmacol Ther 2001;92:147–163.

    Article  CAS  Google Scholar 

  22. Sarlis NJ, Gourgiotis L. Hormonal effects on drug metabolism through the CYP system: perspectives on their potential significance in the era of pharmacogenomics. Curr Drug Targets 2005;5:439–448.

    CAS  Google Scholar 

  23. Boucher BA, Wood GC, Swanson JM. Pharmacokinetic changes in critical illness. Crit Care Clin 2006;22:255–271.

    Article  CAS  Google Scholar 

  24. Brotanek JM, Gosz J, Weitzman M, Flores G. Iron deficiency in early childhood in the United States: risk factors and racial/ethnic disparities. Pediatrics 2007;120:568–575.

    Article  Google Scholar 

  25. Abidoye RO, Soroh KW. A study on the effects of urbanization on the nutritional status of primary school children in Lagos, Nigeria. Nutr Health 1999;13:141–151.

    CAS  Google Scholar 

  26. Stratton RJ, Elia M. Deprivation linked to malnutrition risk and mortality in hospital. Br J Nutr 2006;96:870–876.

    Article  CAS  Google Scholar 

  27. Gerasimidis K, Drongitis P, Murray L, Young D, McKee RF. A local nutritional screening tool compared to malnutrition universal screening tool. Eur J Clin Nutr 2007;61(7):916–932.

    Article  CAS  Google Scholar 

  28. Guigoz Y. The Mini Nutritional Assessment (MNA®) review of the literature; what does it tell us? J Nutr 2007;10:466–487.

    Google Scholar 

  29. Corish CA, Kennedy NP. Protein-energy undernutrition in hospital in-patients. Br J Nutr 2000 Jun;83(6):575–91.

    Article  CAS  Google Scholar 

  30. Johnson MA, Merlini G, Sheldon J, Ichihara K. Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition. Clin Chem Lab Med 2007;45(3):419–426.

    Article  CAS  Google Scholar 

  31. Devoto G, Gallo F, Marchello C, Racchi O, Garbarini R, Bonassi S, Albalustri G, Haupt E. Prealbumin serum concentrations as a useful tool in the assessment of malnutrition in hospitalized patients. Clin Chem 2006;12:2281–2285.

    Article  CAS  Google Scholar 

  32. Ingenbleek Y. [Prealbumin and the nutritional status of the newborn infant] Pediatrie. 1984 Jul-Aug;39(5):399–403.

    CAS  Google Scholar 

  33. Ferard G, Gaudias J, Bourguignat A, Ingenbleek T. C-reactive protein to transthyretin ratio for the early diagnosis and follow-up of postoperative infection. Clin Chem Lab Med 2002;40:1334–1338.

    Article  CAS  Google Scholar 

  34. Hoffer JT. Metabolic consequences of starvation. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition In Health and Disease 9th ed. Philadelphia, PA: Lipppincott Williams & Wilkins, 1999:645–666.

    Google Scholar 

  35. Liu T, Howard RM, Mancini AJ, Weston WL, Paller AS, Drolet BA, Esterly NB, Levy ML, Schachner L, Frieden IJ. Kwashiorkor in the United States: fad diets, perceived and true milk allergy, and nutritional ignorance. Arch Dermatol 2001;137:630–636.

    CAS  Google Scholar 

  36. Basu TK. Interaction of drugs and nutrition. J Human Nutr 1977;31:449–458.

    CAS  Google Scholar 

  37. Walter-Sack I, Klotz U. Influence of diet and nutritional status on drug metabolism. Clin Pharmacokinet 1996;31:47–64.

    Article  CAS  Google Scholar 

  38. Mehta S, Nain CK, Sharma B, Mathur VS. Drug metabolism in malnourished children. Nutrition in Health and Disease and International Development Symposium from XII. International Congress of Nutrition. 1981;739–746.

    Google Scholar 

  39. Poskitt EME. Clinical problems related to the use of drugs in malnutrition. Proc Nutr Soc 1974;33:203–207.

    Article  CAS  Google Scholar 

  40. Mora RJF. Malnutrition: organic and functional consequences. World J Surg 1999;23:530–535.

    Article  CAS  Google Scholar 

  41. Krishnaswamy K. Nutrition and drug metabolism. Indian J Med Res 1978;68:109–120.

    Google Scholar 

  42. Mehta S. Malnutrition and drugs: clinical implications. Dev Pharmacol Ther 1990;15:159–165.

    CAS  Google Scholar 

  43. Lieber CS. Alcohol: its metabolism and interaction with nutrients. Annu Rev Nutr 2000;20:395–430.

    Article  CAS  Google Scholar 

  44. Tranvouez JL, Lerebours E, Chretien P, Fouin-Fortunet H, Colin R. Hepatic antipyrine metabolism in malnourished patients: influence of the type of malnutrition and course after nutritional rehabilitation. Am J Clin Nutr 1985;41:1257–1264.

    CAS  Google Scholar 

  45. Owen OE, Felig P, Morgan AP, Wahren J, Cahill GF. Liver and kidney metabolism during prolonged starvation. J Clin Invest 1969;48:574–583.

    Article  CAS  Google Scholar 

  46. Ramesh R, Kalamegham R, Chary AK, Krishnaswamy K. Hepatic drug metabolizing enzymes in undernourished man. Toxicology 1985;37:259–266.

    Article  Google Scholar 

  47. Lee JH, Suh OK, Lee MG. Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes. Arch Pharm Res 2004;27:693–712.

    Article  CAS  Google Scholar 

  48. Cho MK, Kim YG, Lee MG, Kim SG. Suppression of rat hepatic cytochrome P450 s by protein-calorie malnutrition: complete or partial restoration by cysteine or methionine supplementation. Arch Biochem Biophys 1999;372:150–158.

    Article  CAS  Google Scholar 

  49. Cho MK, Kim YG, Lee MG, Kim SG. Prevention of c-Jun/activator protein-1 activation and microsomal epoxide hydrolase induction in the rat liver by cysteine during protein-calorie malnutrition. Biochem Pharmacol 2001;61:15–24.

    Article  CAS  Google Scholar 

  50. Mao ZL, Tam YK, Coutts RT. Effect of protein and calorie malnutrition on drug metabolism in rat – in vitro. J Pharm Pharmaceut Sci 2006;9:60–70.

    CAS  Google Scholar 

  51. Gunther T, Rebentisch E, Vormann J, Konig M, ising H. Enhanced ototoxicity of gentamicin and salicylate caused by Mg deficiency and Zn deficiency. Biol Trace Element Res 1988;16:43–50.

    Article  CAS  Google Scholar 

  52. Bredberg E, Paalzow LK. Altered pharmacokinetics and dynamics of apomorphine in the malnourished rat: modeling of the composed relationship between concentration and heart-rate response. Pharm Res 1990;7:318–324.

    Article  CAS  Google Scholar 

  53. Williams ML, Mager DE, Parenteau H, et al. Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats. Drug Metab Disp 2004;32:786–793.

    Article  CAS  Google Scholar 

  54. Kim YG, Cho MK, Kwon JW, et al. Effects of cysteine on the pharmacokinetics of intravenous phenytoin in rats with protein-calorie malnutrition. Int J Pharm 2001;229:45–55.

    Article  CAS  Google Scholar 

  55. Lautermann J, Schacht J. Reduced nutritional status enhances ototoxicity [German]. Laryngo 1995;74:724–727.

    Article  CAS  Google Scholar 

  56. Brinker KR, Bulger RE, Dobyan DC, Stacey TR, Southern PM, Henrich WL, Cronin RE. Effect of potassium depletion on gentamicin nephrotoxicity. J Lab Clin Med 1981;98:292–301.

    CAS  Google Scholar 

  57. Kohli K, Aggarwal KK, Bhatt IN. The pharmacokinetic profile of chloramphenicol in protein-malnourished rats. Indian J Med Res 1981;73:208–217.

    CAS  Google Scholar 

  58. Smith JA, Butler TC, Poole DT. Effect of protein depletion in guinea-pigs on glucuronate conjugation of chloramphenicol by liver microsomes. Biochem Pharmacol 1973;22:981–983.

    Article  CAS  Google Scholar 

  59. Thabrew MI, Emerole GO, Olorunsogo OO. Effect of chloramphenicol on hepatic mitochondrial and microsomal functions in protein-energy malnourishment. Res Commun Chem Pathol Pharmacol 1982;38:481–495.

    CAS  Google Scholar 

  60. Ahn CY, Kim EJ, Kwon JW, et al. Effects of cysteine on the pharmacokinetics of intravenous clarithromycin in rats with protein-calorie malnutrition. Life Sci 2003;73:1783–1794.

    Article  CAS  Google Scholar 

  61. Lee AEK, Ahn CY, Kim EJ, et al. Effects of cysteine on the pharmacokinetics of itraconazole in rats with protein-calorie malnutrition. Biopharm Drug Disp 2003;24:63–70.

    Article  CAS  Google Scholar 

  62. Bae SK, Lee SJ, Kwon JW, kim WB, Lee MG. Effects of protein-calorie malnutrition on the pharmacokinetics of DA-7867, a new oxazolidinone, in rats. J Pharm Pharmacol 2004;56:635–642.

    Article  CAS  Google Scholar 

  63. Nehru B, Mehta S, Nain CK, Mathur VS. Disposition of sulphadiazine in young rhesus monkeys with protein calorie malnutrition. Int J Clin Pharmacol Ther Toxicol 1988;26:509–512.

    CAS  Google Scholar 

  64. Sodhi CP, Rana SF, Attri S, Mehta S, Yaiphei K, Mehta SK. Oxidative hepatic injury if isoniazid-rifampicin in young rats subjected to protein and energy malnutrition. Drug Chem Toxicol 1998;21:305–317.

    Article  CAS  Google Scholar 

  65. Sodhi CP, Rana SV, Mehta SK, Vaiphei K, Attri S, Thakur S, Mehta S. Study of oxidative stress in isoniazid-induced hepatic injury in young rats with and without protein-energy malnutrition. J Biochem Toxicol 1996;11:139–146.

    Article  CAS  Google Scholar 

  66. Kim SH, Lee MG. Influence of protein and calorie malnutrition on the pharmacokinetics and pharmacodynamics of bumetanide in rats. J Pharm Sci 1993;82:838–843.

    Article  CAS  Google Scholar 

  67. Kim SH, Choi YM, Lee MG. Pharmacokinetics and pharmacodynamics of furosemide in protein-calorie malnutrition. J Pharmacokinet Biopharm 1993;21:1–17.

    Article  CAS  Google Scholar 

  68. Bae SK, Lee DY, Lee AEK, et al. Effects of cysteine on the pharmacokinetics of intravenous torasemide in rats with protein-calorie malnutrition. J Pharm Sci 2004;93:2388–2398.

    Article  CAS  Google Scholar 

  69. Shim HJ, Kim YC, Lee JH, et al. Pharmacokinetics of intravenous and oral DA-8159, a new erectogenic, in rats with protein-calorie malnutrition. J Pharm Pharmacol 2004;56:1543–1550.

    Article  CAS  Google Scholar 

  70. Davis LE, Lenkinski RE, Shinkwin MA, Kressel HY, Daly JM. The effect of dietary protein depletion on hepatic 5-fluorouracil metabolism. Cancer 1993;72:3715–3722.

    Article  CAS  Google Scholar 

  71. Cusack BJ, Young SP, Loseke VL, Hurty MR, Beals L, Olson RD. Effect of a low-protein diet on doxorubicin pharmacokinetics in the rabbit. Cancer Chemother Pharmacol 1992;30:145–148.

    CAS  Google Scholar 

  72. Kim YG, Cho MK, Kwon JW, Kim SG, Lee MG. Effects of cysteine on the pharmacokinetics of intravenous adriamycin in rats with protein-calorie malnutrition. Res Comm Molec Pathol Pharmacol 2000;107:361–376.

    CAS  Google Scholar 

  73. Mihranian MH, Wang YM, Daly JM. Effects of nutritional depletion and repletion on plasma methotrexate pharmacokinetics. Cancer 1984;54:2268–2271.

    Article  CAS  Google Scholar 

  74. Charland SL, Bartlett D, Torosian MH. Effect of protein-calorie malnutrition on methotrexate pharmacokinetics. J Parenter Enter Nutr 1994;18:45–49.

    Article  CAS  Google Scholar 

  75. Bae SK, Yang SH, Kim JW, Kim T, Kwon JW, Lee MG. Effects of cysteine on the pharmacokinetics of oltipraz in rats with protein-calorie malnutrition. J Pharm Sci 2005;94:1484–1493.

    Article  CAS  Google Scholar 

  76. Kim YG, Cho MK, Kwon JW, Kim DH, Kim SG, Lee MG. Effects of cysteine on the pharmacokinetics of intravenous 2-(allylthio)pyrazine, a new chemoprotective agent, in rats with protein-calorie malnutrition. Int J Pharm 2003;255:1–11.

    Article  CAS  Google Scholar 

  77. Lee DY, Lee I, Lee MG. Effects of cysteine on the pharmacokinetic parameters of omeprazole in rats with protein-calorie malnutrition: partial restoration of some parameters to control levels by oral cysteine supplementation. J Parenter Enteral Nutr 2007;31:37–46.

    Article  CAS  Google Scholar 

  78. Mehta S, Nain CK, Sharma B, Mathur VS. Disposition of four drugs in malnourished children. Drug Nutr Interact 1982;1:205–211.

    CAS  Google Scholar 

  79. Schenker S, Speeg KV, Perez A, Finch J. The effects of food restriction in man on hepatic metabolism of acetaminophen. Clin Nutr 2001;20:145–150.

    Article  CAS  Google Scholar 

  80. Lares-Asseff I, Flores-Perez J, Juarez-Olguin H, Ramirez-Lacayo M, Laredo-Abdala A, Carbajal-Rodriguez L. The influence of nutritional status on the pharmacokinetics of ASA and its metabolites in children with autoimmune diseases. Am J Clin Nutr 1999;69:318–324.

    CAS  Google Scholar 

  81. Maitland K, Berkley JA, Shebbe M, et al. Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol? PLoS Med 2006;3:2431–2439.

    Article  Google Scholar 

  82. Bravo ME, Arancibia A, Jarpa S. Carpentier PM, Jahn AN. Pharmacokinetics of gentamicin in malnourished infants. Eur J Clin Pharmacol 1982;21:499–504.

    Article  CAS  Google Scholar 

  83. Samotra K, Gupte S, Raina RK. Pharmacokinetics of gentamicin in protein-energy malnutrition. Eur J Clin Pharmacol 1985;29:255–256.

    Article  CAS  Google Scholar 

  84. Buchanan N, Davis MD, Eyberg C. Gentamicin pharmacokinetics in kwashiorkor. Br J Clin Pharmacol 1979;8:451–453.

    CAS  Google Scholar 

  85. Khan AM, Ahmed T, Alam NH, Chowdhury AK, Fuchs GJ. Extended-interval gentamicin admiration in malnourished children. J Trop Pediatr 2005;52:179–184.

    Article  Google Scholar 

  86. Ronchera-Oms CL, Tormo C, Ordovas JP, Abad J, Jimenez NV. Expanded gentamicin volume of distribution in critically ill adult patients receiving total parenteral nutrition. J Clin Pharm Ther 1995;20:253–258.

    Article  CAS  Google Scholar 

  87. Gamba G, Contreras AM, Cortes J, et al. Hypoalbuminemia as a risk factor for amikacin nephrotoxicity. Rev Invest Clin 1990;42:204–209.

    CAS  Google Scholar 

  88. Mulholland K, Falade AG, Corrah PT, Omosigho C, N’Jai P, Giadom B, Adegbola RA, Tschappeler K, Todd J, Greenwood BM. A randomized trial of chloramphenicol vs trimethoprim-sulfamethoxazole for the treatment of malnourished children with community-acquired pneumonia. Pedi Infect Dis J 1995;14:959–965.

    Article  CAS  Google Scholar 

  89. Eriksson M, Paalzow L, Bolme P, Mariam TW. Chloramphenicol pharmacokinetics in Ethiopian children of differing nutritional status. Clin Pharmacol 1983;24:819–823.

    Article  CAS  Google Scholar 

  90. Ashton R, Boime P, Alemayehu E, Eriksson M, Paalzow L. Decreased chloramphenicol clearance in malnourished Ethiopian children. Clin Pharmacol 1993;45:181–186.

    Article  CAS  Google Scholar 

  91. Lares-Asseff I, Lugo-Goytia G, Perez-Guillé, et al. Bayesian prediction of chloramphenicol blood levels in children with sepsis and malnutrition [Spanish]. Rev Invest Clin 1999;51:159–165.

    CAS  Google Scholar 

  92. Raghuram TC, Krishnaswamy K. Pharmacokinetics and plasma steady-state levels of doxycycline in undernutrition. Br J Pharmacol 1982;14:785–78.

    CAS  Google Scholar 

  93. Di Palo S, Ferrari G, Castoldi R, Braga M, Cristallo M, Staudacher C, Chiesa R, Di Carlo V. Effectiveness of antibiotic prophylaxis according to the nutritional status in patients undergoing contaminated procedures. Ital J Surg Sci. 1988;18:223–226.

    Google Scholar 

  94. Mehta S, Nain CK, Sharma B, Mathur VS. Metabolism of sulfadiazine in children with protein calorie malnutrition. Pharmacology 1980;21:369–374.

    Article  CAS  Google Scholar 

  95. Bolme P, Eriksson M, Paazlow L, et al. Malnutrition and pharmacokinetics of penicillin in Ethiopian children. Pharmacol Toxicol 1995;76:259–262.

    Article  CAS  Google Scholar 

  96. Buchanan N, Robinson R, Koornhof HJ, Eyberg C. Penicillin pharmacokinetics in kwashiorkor. Am J Clin Nutr 1979;32:2233–2236.

    CAS  Google Scholar 

  97. Pussard E, Barennes H, Daouda H, et al. Quinine disposition in globally malnourished children with cerebral malaria. Clin Pharmacol Ther 1999;65:500–510.

    Article  CAS  Google Scholar 

  98. Tréluyer JM, Roux A, Mugnier C, Flouvat B, Lagardère B. metabolism of quinine in children with global malnutrition. Pediatr Res 1996;40:558–563.

    Article  Google Scholar 

  99. Tulpule A, Krishnaswamy K. Chloroquine kinetics in the undernourished. Eur J Clin Pharmacol 1984;24:273–276.

    Article  Google Scholar 

  100. Caulfield LE, Richard SA, Black RE. Undernutrition as an underlying cause of malaria morbidity and mortality in children less than five years old. Am J Trop Med Hygiene 2004;71(Suppl 2):55–63.

    Google Scholar 

  101. Mayxay M, Taylor AM, Khanthavong M, et al. Thiamin deficiency and uncomplicated falciparum malaria in Laos. Trop Med Int Health 2007;12:363–369.

    Article  CAS  Google Scholar 

  102. Anderson SH, Vickery CA, Nicol AD. Adult thiamine requirements and the continuing need to fortify processed cereals. Lancet 1986;2:85–89.

    Article  CAS  Google Scholar 

  103. Eriksson M, Bolme P, Habte D, Paalzow L. INH and streptomycin in Ethiopian children with tuberculosis and different nutritional status. Acta Paediatr Scand 1988;77:890–894.

    Article  CAS  Google Scholar 

  104. Polasa K, Murthy KJR, Krishnaswamy K. Rifampicin kinetics in undernutrition. Br J Clin Pharmacol 1984;17:481–484.

    CAS  Google Scholar 

  105. Seifart HI, Donald PR, De Villiers JN, Parkin DP, Jaarsveld PP. Isoniazid elimination kinetics in children with protein-energy malnutrition treated for tuberculous meningitis with a four-component antimicrobial regimen. Ann Tropical Paediatrics 1995;15:249–254.

    CAS  Google Scholar 

  106. Graham SM, Bell DJ, Nyirongo S, Hartkoorn R, Ward SA, Molyneux EM. Low levels of pyrazinamide and ethambutol in children with tuberculosis and impact of age, nutritional status, and human immunodeficiency virus infection. Antimicrob Agents Chemother 2006;50:407–413.

    Article  CAS  Google Scholar 

  107. Shastri RA Krishnaswamy K. Metabolism of sulphadiazine in malnutrition. Br J Clin Pharmacol 1979;7:69–73.

    CAS  Google Scholar 

  108. Shastri RA Krishnaswamy K. Undernutrition and tetracycline half-life. Clin Chim Acta 1976;66:157–164.

    Article  CAS  Google Scholar 

  109. Kitt TM,Park GC, Spector R, Lawton W, Tsalikian E. Renal clearance of oxipurinol and inulin on an isocaloric, low protein diet. Clin Pharmacol Ther 1988;43:681–687.

    Article  Google Scholar 

  110. Park GD, Berlinger W, Spector R, Kitt TM, Tsalikian E. Sustained reductions in oxipurinol renal clearance during a restricted diet. Clin Pharmacol Ther 1987;41:616–621.

    Article  CAS  Google Scholar 

  111. Kitt TM, Park GD, Spector R, Tsalikian E. Reduced renal clearance of oxypurinol during a 400 calorie protein-free diet. J Clin Pharmacol 1989;29:65–71.

    CAS  Google Scholar 

  112. Berlinger WG, Park GD, Spector R. The effect of dietary protein on the clearance of allopurinol and oxypurinol. N Engl J Med 1985;313:771–776.

    Article  CAS  Google Scholar 

  113. Murry DJ, Riva L, Poplack DG. Impact of nutrition on pharmacokinetics of anti-neoplastic agents. Int J Cancer 1998;11:48–51.

    Article  CAS  Google Scholar 

  114. Gurney H. Defining the starting dose. In:Figg WD, McLeod HL, eds. Handbook of anticancer pharmacokinetics and pharmacodynamics. Totowa, NJ: Humana Press, 2004:57–73.

    Google Scholar 

  115. Rajeswari R, Shetty PA, Gothoskar BP, Akolkar PN, Gokhale SV. Pharmaokinetics of methotrexate in adult Indian patients and its relationship to nutritional status. Cancer Treat Rep 1984;68:727–732.

    CAS  Google Scholar 

  116. Obama M, Cangir A, van Eys J. Nutritional status and anthracycline cardiotoxicity in children. South Med J 1983;76:577–578.

    CAS  Google Scholar 

  117. Gersema LM, Park GD, Kitt TM, Spector R. The effect of dietary protein-calorie restriction on the renal elimination of cimetidine. Clin Pharmacol Ther 1987;42:471–475.

    Article  CAS  Google Scholar 

  118. Lares-Asseff I, Zaltzman S, Guillé MGP, et al. Pharmacokinetics of cyclosporine as a function of energy-protein deficiency in children with chronic renal failure. J Clin Pharmacol 1997;37:179–185.

    CAS  Google Scholar 

  119. Don BR, Spin G, Nestorov I, Hutmacher M, Rose A, Kaysen GA. The pharmacokinetics of etanercept in patients with end-stage renal disease on haemodialysis. J Pharm Pharmacol 2005;57:1407–1413.

    Article  CAS  Google Scholar 

  120. Kim YG, Kim SK, Kwon JW, et al. Effects of cysteine on amino acid concentrations and transsulferation enzyme activities in rat liver with protein-calorie malnutrition. Life Sci 2003;72:1171–1181.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Associate Professor of Nutrition, University of Pennsylvania, Philadelphia, PA, USA

    Charlene W. Compher PHD, RD, FADA, CNSD

  2. Associate Professor of Pharmacology and Therapeutics, University of Pennsylvania, School of Nursing, Philadelphia, PA, USA

    Joseph I. Boullata PHARMD, BCNSP

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  1. Charlene W. Compher PHD, RD, FADA, CNSD
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  1. School of Nursing, University of Pennsylvania, Guardian Dr. 420, Philadelphia, 19104, U.S.A.

    Joseph I. Boullata

  2. Dept. Surgery, Temple University Hospital, N. Broad St. 3401, Philadelphia, 19140, U.S.A.

    Vincent T. Armenti

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Compher, C.W., Boullata, J.I. (2009). Influence of Protein-Calorie Malnutrition on Medication. In: Boullata, J., Armenti, V. (eds) Handbook of Drug-Nutrient Interactions. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-60327-362-6_6

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