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Sexually Transmitted Diseases

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Management of Antimicrobials in Infectious Diseases

Part of the book series: Infectious Disease ((ID))

Abstract

Sexually transmitted diseases (STDs) affect an estimated 19 million people a year in the United States. Clinicians who may encounter patients with STDs need to be aware of treatment guidelines and recent changes in treatment recommendations. For example, due to increased resistance, fluoroquinolones are no longer recommended for the treatment of infections due to Neisseria gonorrhoeae. Recent new approaches also include prevention strategies for human papillomavirus (HPV).

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References

  1. Workowski KA, Berman SM (2006). Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep 55:1–94

    PubMed  Google Scholar 

  2. Cohen MS (1998). Sexually transmitted diseases enhance HIV transmission: No longer a hypothesis. Lancet 351(Suppl 3):5–7

    Article  PubMed  Google Scholar 

  3. Eng T, Butler W (1997). The Neglected Health and Economic Impact of STD’s. The Hidden Epidemic: Confronting Sexually Transmitted Disease. Washington, DC: National Academy Press

    Google Scholar 

  4. CDC (1998). HIV prevention through early detection and treatment of other sexually transmitted disease-US recommendations of the advisory committee for HIV and STD prevention. MMWR 47:1–24

    Google Scholar 

  5. Spinola SM (2008). Chancroid and Haemophilus ducreyi. In: Holmes K, Sparling P, Stamm W, et al. (eds.) Sexually Transmitted Diseases, 4th ed. New York: McGraw Hill, 689–699

    Google Scholar 

  6. Tyndall M, Malisa M, Plummer FA et al. (1993). Ceftriaxone no longer predictably cures chancroid in Kenya. J Infect Dis 167:469–471

    Article  PubMed  CAS  Google Scholar 

  7. Knapp JS, Back AF, Babst AF et al. (1993). In vitro susceptibilities of isolates of Haemophilus ducreyi from Thailand and the United States to currently recommended and newer agents for treatment of chancroid. Antimicrob Agents Chemother 37:1552–1555

    PubMed  CAS  Google Scholar 

  8. Wald A (1999). New therapies and prevention strategies for genital herpes. Clin Infect Dis 28:S4–S13

    Article  PubMed  Google Scholar 

  9. Lawrence C, Wald A (2008). Genital Herpes. In: Holmes K, Sparling P, Stamm W, et al. (eds.) Sexually Transmitted Diseases, 4th ed. New York: McGraw Hill.

    Google Scholar 

  10. Fife KH, Crumpacker CS, Mertz GJ et al. (1994). Recurrence and resistance patterns of herpes simplex virus following cessation of >6 years of chronic suppression with acyclovir. J Infect Dis 177:542–550

    Google Scholar 

  11. Kessler HA, Hurwitz S, Farthing C et al. (1996). Pilot study of topical trifluridine for the treatment of acyclovir-resistant mucocutaneous herpes simplex disease in patients with AIDS (ACTG 172). AIDS Clinical Trials Group. J Acquir Immune Defic Syndr Hum Retrovirol 12:147–152

    Article  PubMed  CAS  Google Scholar 

  12. Sparling PF, Swartz MN, Musher DM et al. (2008). Clinical Manifestations of Syphilis. In: Holmes K, Sparling P, Stamm W, et al. (eds) Sexually Transmitted Diseases, 4th ed. New York: McGraw Hill.

    Google Scholar 

  13. CDC (2006). Primary and secondary syphilis – United States, 2003–2004. MMWR 55:269–273

    Google Scholar 

  14. Tramont EC (1995). Syphilis in adults: From Christopher Columbus to Sir Alexander Fleming to AIDS. Clin Infect Dis 21:1361–1369

    Article  PubMed  CAS  Google Scholar 

  15. CDC (2008). Syphilis testing algorithms using treponemal tests for initial screening – Four laboratories, New York City, 2005–2006. MMWR 57:872–875

    Google Scholar 

  16. Sanchez PJ, Wendel GD (1997). Syphilis in pregnancy. Clin Perinatol 24:71–90

    PubMed  CAS  Google Scholar 

  17. Riedner G, Rusizoka M, Todd J et al. (2005). Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis. N Engl J Med 353:1236–1244

    Article  PubMed  CAS  Google Scholar 

  18. Holmes KK (2005). Azithromycin versus penicillin G benzathine for early syphilis. N Engl J Med 353:1291–1293

    Article  PubMed  CAS  Google Scholar 

  19. Rolfs RT, Joesoef MR, Hendershot EF et al. (1997). A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group. N Engl J Med 337:307–314

    Article  PubMed  CAS  Google Scholar 

  20. Wiley DJ, Douglas J, Beutner K et al. (2002). External genital warts: Diagnosis, treatment, and prevention. Clin Infect Dis 35:S210–S224

    Article  PubMed  CAS  Google Scholar 

  21. Winer RL, Koutsky LA (2008). Genital Human Papillomavirus Infection. In: Holmes KK, Sparling PF, Stamm W, et al. (eds.) Sexually Transmitted Diseases, 4th ed. New York: McGraw Hill, 489–508

    Google Scholar 

  22. Beutner KR, Wiley DJ, Douglas JM et al. (1999). Genital warts and their treatment. Clin Infect Dis 28 (Suppl 1):S37–S56

    Article  PubMed  Google Scholar 

  23. Prevention CDC (2007). Sexually Transmitted Disease Surveillance, 2006. In: Services USDoHaH, (ed.) Atlanta, GA, 2007

    Google Scholar 

  24. Barr J, Danielson D (1971). Septic gonococcal arthritis. BMJ 1:482–485

    Article  PubMed  CAS  Google Scholar 

  25. Sharp JT (1974). Editorial: Gonococcal infections and arthritis. Arthritis Rheum 17:511–512

    Article  PubMed  CAS  Google Scholar 

  26. Gorwitz RJ, Nakashima AK, Moran JS et al. (1993). Sentinel surveillance for antimicrobial resistance in Neisseria gonorrhoeae – United States, 1988–1991. The gonococcal isolate surveillance project study group. MMWR CDC Surveill Summ 42:29–39

    PubMed  CAS  Google Scholar 

  27. Ison CA, Dillon JA, Tapsall JW (1998). The epidemiology of global antibiotic resistance among Neisseria gonorrhoeae and Haemophilus ducreyi. Lancet 351(Suppl 3):8–11

    Article  PubMed  Google Scholar 

  28. Giles JA, Falconio J, Yuenger JD et al. (2004). Quinolone resistance-determining region mutations and por type of Neisseria gonorrhoeae isolates: Resistance surveillance and typing by molecular methodologies. J Infect Dis 189:2085–2093

    Article  PubMed  CAS  Google Scholar 

  29. Jones RB, Van der Pol B, Martin DH et al. (1990). Partial characterization of Chlamydia trachomatis isolates resistant to multiple antibiotics. J Infect Dis 162:1309–1315

    Article  PubMed  CAS  Google Scholar 

  30. Moran JS (1995). Treating uncomplicated Neisseria gonorrhoeae infections: Is the anatomic site of infection important? Sex Transm Dis 22:39–47

    Article  PubMed  CAS  Google Scholar 

  31. CDC (1998). Fluoroquinolone-resistant Neisseria gonorrhoeae – San Diego, California, 1997. MMWR Morb Mortal Wkly Rep 47:405–408

    Google Scholar 

  32. Anderson MR, Klink K, Cohrssen A (2004). Evaluation of vaginal complaints. J Am Med Assoc 291:1368–1379

    Article  CAS  Google Scholar 

  33. Carr PL, Rothberg MB, Friedman RH et al. (2005). “Shotgun” versus sequential testing. Cost-effectiveness of diagnostic strategies for vaginitis. J Gen Intern Med 20:793–799

    Article  PubMed  Google Scholar 

  34. Fredricks DN, Fiedler TL, Thomas KK et al. (2007). Targeted PCR for detection of vaginal bacteria associated with bacterial vaginosis. J Clin Micro 45:3270–3276

    Article  CAS  Google Scholar 

  35. Amsel R, Totten PA, Spiegel CA et al. (1983). Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med 74:14–22

    Article  PubMed  CAS  Google Scholar 

  36. Nugent RP, Krohn MA, Hillier SL (1991). Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Micro 29: 297–301

    CAS  Google Scholar 

  37. Moodley P, Connolly C, Sturm AW (2002). Interrelationships among human immunodeficiency virus type 1 infection, bacterial vaginosis, trichomoniasis, and the presence of yeasts. J Infect Dis 185:69–73

    Article  PubMed  Google Scholar 

  38. Martin HL, Richardson BA, Nyange PM et al. (1999). Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition. J Infect Dis 180:1863–1868

    Article  PubMed  CAS  Google Scholar 

  39. Nyirjesy P (2008). Vulvovaginal candidiasis and bacterial vaginosis. Infect Dis Clin North Am 22:637–652

    Article  PubMed  Google Scholar 

  40. Livengood CH, III, Ferris DG, Wiesenfeld HC et al. (2007). Effectiveness of two tinidazole regimens in treatment of bacterial vaginosis: A randomized controlled trial. Obstet Gynecol 110:302–309

    Article  PubMed  CAS  Google Scholar 

  41. Cates W, Jr. (1999). Estimates of the incidence and prevalence of sexually transmitted diseases in the United States. American Social Health Association Panel. Sex Transm Dis 26:S2–S7

    Article  PubMed  Google Scholar 

  42. Van der Pol B, Kraft B, Williams JA (2006). Use of an adaptation of a commercially available PCR assay aimed at diagnosis of Chlamydia and gonorrhea to detect Trichomonas vaginalis in urogenital specimens. J Clin Micro 44:366–373

    Article  Google Scholar 

  43. Van Der Pol B, Kwok C, Pierre-Louis B et al. (2008). Trichomonas vaginalis infection and human immunodeficiency virus acquisition in African women. J Infect Dis 197:548–554

    Article  Google Scholar 

  44. Wendel KA, Workowski KA (2007). Trichomoniasis: Challenges to appropriate management. Clin Infect Dis 44 (Suppl 3):S123–S129

    Article  PubMed  Google Scholar 

  45. Sobel JD, Nyirjesy P, Brown W (2001). Tinidazole therapy for metronidazole-resistant vaginal trichomoniasis. Clin Infect Dis 33:1341–1346

    Article  PubMed  CAS  Google Scholar 

  46. Sobel J (2008). Vulvovaginal Candidiasis. In: Holmes KK, Sparling PF, Stamm W, et al. (eds.) Sexually Transmitted Diseases, 4th ed. New York: McGraw Hill

    Google Scholar 

  47. Scholes D, Stergachis A, Heidrich FE et al. (1996). Prevention of pelvic inflammatory disease by screening for cervical chlamydial infection. N Engl J Med 334:1362–1366

    Article  PubMed  CAS  Google Scholar 

  48. Meinking T (1999). Infestations. Curr Probl Dermatol 11:73–120

    Article  Google Scholar 

  49. CDC (2007). Update to CDC’s Sexually Transmitted Diseases Treatment Guidelines, 2006: Fluoroquinolones No Longer Recommended for Treatment of Gonococcal Infections. MMWR 56:332–336

    Google Scholar 

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Correspondence to Alice C. Thornton .

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Thornton, A.C., Stevich, B., Arno, J.N., Van Der Pol, B. (2010). Sexually Transmitted Diseases. In: Mainous III, A., Pomeroy, C. (eds) Management of Antimicrobials in Infectious Diseases. Infectious Disease. Humana Press. https://doi.org/10.1007/978-1-60327-239-1_11

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  • DOI: https://doi.org/10.1007/978-1-60327-239-1_11

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