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The Niche Regulation of Hematopoietic Stem Cells

  • Chapter
Regulatory Networks in Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Stem cells’ major capabilities, that is, pluripotency and self-renewal, are key to sustaining the lifelong functionality of organs. Stem cells reside in the special microenvironment called the niche. The niche and stem cells adhere to each other via adhesion molecules and exchange the molecular signals that maintain stem cell features. It has been suggested that tumor tissue also contains such type of cells.

In this chapter, the hematopoietic system is used as an example to show the interaction between the stem cell and its niche. Different kinds of niches and regulatory mechanisms are explained. Furthermore, the niche’s involvement in cancer stem regulation, tumor invasion, and metastasis, and novel therapeutic approaches used in association with the cancer stem cell niche are also described.

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Notes

  1. 1.

    This article was published in Blood Cells, 4, Schofield R, The relationship between the spleen colony-forming cell and the haematopoietic stem cell, 7–25, Copyright (1978).

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Author information

Authors and Affiliations

  1. Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku, Tokyo, Japan

    Hiroko Iwasaki & Toshio Suda

Authors
  1. Hiroko Iwasaki
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  2. Toshio Suda
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Corresponding author

Correspondence to Hiroko Iwasaki .

Editor information

Editors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Vinagolu K. Rajasekhar MSc, MPhil, PhD

  2. Invitrogen Corporation, Frederick, MD, USA

    Mohan C. Vemuri Ph.D.

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC, a part of Springer Science+Business Media, LLC

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Iwasaki, H., Suda, T. (2009). The Niche Regulation of Hematopoietic Stem Cells. In: Rajasekhar, V.K., Vemuri, M.C. (eds) Regulatory Networks in Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-60327-227-8_15

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