Skip to main content
SpringerLink
Log in

Allogeneic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia (ALL)

  • Chapter
  • First Online:
Allogeneic Stem Cell Transplantation

Part of the book series: Contemporary Hematology ((CH))

  • 1476 Accesses

Abstract

Conventional treatment for adult acute lymphoblastic leukemia (ALL) consists of sequentially administered cycles of combination chemotherapy involving an induction, consolidation/intensification, and maintenance phase which is modeled on clinical protocols developed for the treatment of childhood ALL. With this approach, even though a majority of patients (80-92%) achieve complete remission, only one-third of patient or less are long-term survivors. The long-term survival has not changed for over a decade [1-7]. Thus, consolidation of remission is vital in achieving long-term survival in this disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Pui CH, Evans WE (2006) Treatment of acute lymphoblastic leukemia. N Engl J Med 354:166-178

    Article  PubMed  CAS  Google Scholar 

  2. Gokbuget N, Hoelzer D, Arnold R et al (2000) Treatment of adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL). Hematol Oncol Clin North Am 14:1307-1325 ix

    Article  PubMed  CAS  Google Scholar 

  3. Linker C, Damon L, Ries C, Navarro W (2002) Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia. J Clin Oncol 20:2464-2471

    Article  PubMed  CAS  Google Scholar 

  4. Annino L, Vegna ML, Camera A et al (2002) Treatment of adult acute lymphoblastic leukemia (ALL): Long-term follow-up of the GIMEMA ALL 0288 randomized study. Blood 99:863-871

    Article  PubMed  CAS  Google Scholar 

  5. Takeuchi J, Kyo T, Naito K et al (2002) Induction therapy by frequent administration of doxorubicin with four other drugs, followed by intensive consolidation and maintenance therapy for adult acute lymphoblastic leukemia: the JALSG-ALL93 study. Leukemia 16:1259-1266

    Article  PubMed  CAS  Google Scholar 

  6. Kantarjian H, Thomas D, O’Brien S et al (2004) Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. Cancer 101:2788-2801

    Article  PubMed  CAS  Google Scholar 

  7. Durrant IJ, Prentice HG, Richards SM (1997) Intensification of treatment for adults with acute lymphoblastic leukaemia: Results of UK Medical Research Council randomized trial UKALL XA. Medical Research Council Working Party on Leukaemia in Adults. Br J Haematol 99:84-92

    Article  PubMed  CAS  Google Scholar 

  8. Hoelzer D, Thiel E, Loffler H et al (1988) Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukemia in adults. Blood 71:123-131

    PubMed  CAS  Google Scholar 

  9. Rowe JM, Buck G, Burnett AK et al (2005) Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993. Blood 106:3760-3767

    Article  PubMed  CAS  Google Scholar 

  10. Moorman AV, Harrison CJ, Buck GA et al (2007) Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 tria. Blood 109:3189-3197

    Article  PubMed  CAS  Google Scholar 

  11. Secker-Walker LM, Craig JM, Hawkins JM, Hoffbrand AV (1991) Philadelphia positive acute lymphoblastic leukemia in adults: Age distribution, BCR breakpoint and prognostic significance. Leukemia 5:196-199

    PubMed  CAS  Google Scholar 

  12. Lazarus HM, Richards SM, Chopra R et al (2006) Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993. Blood 108:465-472

    Article  PubMed  CAS  Google Scholar 

  13. Mortuza FY, Papaioannou M, Moreira IM et al (2002) Minimal residual disease tests provide an independent predictor of clinical outcome in adult acute lymphoblastic leukemia. J Clin Oncol 20:1094-1104

    Article  PubMed  Google Scholar 

  14. Bruggemann M, Raff T, Flohr T et al (2006) Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia. Blood 107:1116-1123

    Article  PubMed  Google Scholar 

  15. Sebban C, Lepage E, Vernant JP et al (1994) Allogeneic bone marrow transplantation in adult acute lymphoblastic leukemia in first complete remission: a comparative study. French Group of Therapy of Adult Acute Lymphoblastic Leukemia. J Clin Oncol 12:2580-2587

    PubMed  CAS  Google Scholar 

  16. Attal M, Blaise D, Marit G et al (1995) Consolidation treatment of adult acute lymphoblastic leukemia: a prospective, randomized trial comparing allogeneic versus autologous bone marrow transplantation and testing the impact of recombinant interleukin-2 after autologous bone marrow transplantation. BGMT Group. Blood 86:1619-1628

    PubMed  CAS  Google Scholar 

  17. Thomas X, Boiron JM, Huguet F et al (2004) Outcome of treatment in adults with acute lymphoblastic leukemia: Analysis of the LALA-94 trial. J Clin Oncol 22:4075-4086

    Article  PubMed  CAS  Google Scholar 

  18. Hunault M, Harousseau JL, Delain M et al (2004) Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: A GOELAMS trial. Blood 104:3028-3037

    Article  PubMed  CAS  Google Scholar 

  19. Zhang MJ, Hoelzer D, Horowitz MM et al (1995) Long-term follow-up of adults with acute lymphoblastic leukemia in first remission treated with chemotherapy or bone marrow transplantation. The Acute Lymphoblastic Leukemia Working Committee. Ann Intern Med 123:428-431

    PubMed  CAS  Google Scholar 

  20. Oh H, Gale RP, Zhang MJ et al (1998) Chemotherapy vs HLA-identical sibling bone marrow transplants for adults with acute lymphoblastic leukemia in first remission. Bone Marrow Transplant 22:253-257

    Article  PubMed  CAS  Google Scholar 

  21. Levine JE, Harris RE, Loberiza FR Jr et al (2003) A comparison of allogeneic and autologous bone marrow transplantation for lymphoblastic lymphoma. Blood 101:2476-2482

    Article  PubMed  CAS  Google Scholar 

  22. Fielding AK, Richards SM, Chopra R et al (2007) Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study. Blood 109:944-950

    Article  PubMed  CAS  Google Scholar 

  23. Tavernier E, Boiron JM, Huguet F et al (2007) Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial. Leukemia 21:1907-1914

    Article  PubMed  CAS  Google Scholar 

  24. Dahlke J, Kroger N, Zabelina T et al (2006) Comparable results in patients with acute lymphoblastic leukemia after related and unrelated stem cell transplantation. Bone Marrow Transplant 37:155-163

    Article  PubMed  CAS  Google Scholar 

  25. Kiehl MG, Kraut L, Schwerdtfeger R et al (2004) Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: no difference in related compared with unrelated transplant in first complete remission. J Clin Oncol 22:2816-2825

    Article  PubMed  Google Scholar 

  26. Cornelissen JJ, Carston M, Kollman C et al (2001) Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: strong graft-versus-leukemia effect and risk factors determining outcome. Blood 97:1572-1577

    Article  PubMed  CAS  Google Scholar 

  27. Eapen M, Rubinstein P, Zhang MJ et al (2007) Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: A comparison study. Lancet 369:1947-1954

    Article  PubMed  Google Scholar 

  28. Laughlin MJ, Eapen M, Rubinstein P et al (2004) Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 351:2265-2275

    Article  PubMed  CAS  Google Scholar 

  29. Marks DI, Aversa F, Lazarus HM (2006) Alternative donor transplants for adult acute lymphoblastic leukaemia: A comparison of the three major options. Bone Marrow Transplant 38:467-475

    Article  PubMed  CAS  Google Scholar 

  30. Gassas A, Sung L, Saunders EF, Doyle JJ (2006) Comparative outcome of hematopoietic stem cell transplantation for pediatric acute lymphoblastic leukemia following cyclophosphamide and total body irradiation or VP16 and total body irradiation conditioning regimens. Bone Marrow Transplant 38:739-743

    Article  PubMed  CAS  Google Scholar 

  31. Marks DI, Forman SJ, Blume KG et al (2006) A comparison of cyclophosphamide and total body irradiation with etoposide and total body irradiation as conditioning regimens for patients undergoing sibling allografting for acute lymphoblastic leukemia in first or second complete remission. Biol Blood Marrow Transplant 12:438-453

    Article  PubMed  CAS  Google Scholar 

  32. Marks DI, Bird JM, Cornish JM et al (1998) Unrelated donor bone marrow transplantation for children and adolescents with Philadelphia-positive acute lymphoblastic leukemia. J Clin Oncol 16:931-936

    PubMed  CAS  Google Scholar 

  33. Kahl C, Storer BE, Sandmaier BM et al (2007) Relapse risk in patients with malignant diseases given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. Blood 110(7):2744-2748

    Article  PubMed  CAS  Google Scholar 

  34. Arnold R, Massenkeil G, Bornhauser M et al (2002) Nonmyeloablative stem cell transplantation in adults with high-risk ALL may be effective in early but not in advanced disease. Leukemia 16:2423-2428

    Article  PubMed  CAS  Google Scholar 

  35. Martino R, Giralt S, Caballero MD et al (2003) Allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning in acute lymphoblastic leukemia: A feasibility study. Haematologica 88:555-560

    PubMed  Google Scholar 

  36. Gutierrez-Aguirre CH, Gomez-Almaguer D, Cantu-Rodriguez OG et al (2007) Non-myeloablative stem cell transplantation in patients with relapsed acute lymphoblastic leukemia: Results of a multicenter study. Bone Marrow Transplant 40(6):535-539

    Article  PubMed  CAS  Google Scholar 

  37. Tavernier E, Boiron JM, Huguet F et al (2007) Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial. Leukemia 21(9):1907-1914

    Article  PubMed  CAS  Google Scholar 

  38. Stein A, O’Donnell M, Snyder DS et al (2007) Reduced-Intensity Stem Cell Tansplantation for high-risk acute lymphoblastic leukaemia. Biol Blood Marrow Transplant 13:134

    Article  Google Scholar 

  39. Preudhomme C, Henic N, Cazin B et al (1997) Good correlation between RT-PCR analysis and relapse in Philadelphia (Ph1)-positive acute lymphoblastic leukemia (ALL). Leukemia 11:294-298

    Article  PubMed  CAS  Google Scholar 

  40. Radich J, Gehly G, Lee A et al (1997) Detection of bcr-abl transcripts in Philadelphia chromosome-positive acute lymphoblastic leukemia after marrow transplantation. Blood 89:2602-2609

    PubMed  CAS  Google Scholar 

  41. Shimoni A, Kroger N, Zander AR et al (2003) Imatinib mesylate (STI571) in preparation for allogeneic hematopoietic stem cell transplantation and donor lymphocyte infusions in patients with Philadelphia-positive acute leukemias. Leukemia 17:290-297

    Article  PubMed  CAS  Google Scholar 

  42. Fielding AK, Goldstone AH (2007) Allogeneic haematopoietic stem cell transplant in Philadelphia-positive acute lymphoblastic leukaemia. Bone Marrow Transplant 41:447-453

    Article  PubMed  Google Scholar 

  43. Dombret H, Gabert J, Boiron JM et al (2002) Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia-results of the prospective multicenter LALA-94 trial. Blood 100:2357-2366

    Article  PubMed  CAS  Google Scholar 

  44. Forman SJ, O’Donnell MR, Nademanee AP et al (1987) Bone marrow transplantation for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 70:587-588

    PubMed  CAS  Google Scholar 

  45. Chao NJ, Blume KG, Forman SJ, Snyder DS (1995) Long-term follow-up of allogeneic bone marrow recipients for Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 85:3353-3354

    PubMed  CAS  Google Scholar 

  46. Barrett AJ, Horowitz MM, Ash RC et al (1992) Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 79:3067-3070

    PubMed  CAS  Google Scholar 

  47. Snyder DS, Nademanee AP, O’Donnell MR et al (1999) Long-term follow-up of 23 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with allogeneic bone marrow transplant in first complete remission. Leukemia 13:2053-2058

    Article  PubMed  CAS  Google Scholar 

  48. Wassmann B, Pfeifer H, Scheuring U et al (2002) Therapy with imatinib mesylate (Glivec) preceding allogeneic stem cell transplantation (SCT) in relapsed or refractory Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL). Leukemia 16:2358-2365

    Article  PubMed  CAS  Google Scholar 

  49. de Labarthe A, Rousselot P, Huguet-Rigal F et al (2007) Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the GRAAPH-2003 study. Blood 109:1408-1413

    Article  PubMed  Google Scholar 

  50. Wassmann B, Pfeifer H, Stadler M et al (2005) Early molecular response to posttransplantation imatinib determines outcome in MRD + Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL). Blood 106:458-463

    Article  PubMed  CAS  Google Scholar 

  51. Spielberger R, Stiff P, Bensinger W et al (2004) Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 351:2590-2598

    Article  PubMed  CAS  Google Scholar 

  52. von Bultzingslowen I, Brennan MT, Spijkervet FK et al (2006) Growth factors and cytokines in the prevention and treatment of oral and gastrointestinal mucositis. Support Care Cancer 14:519-527

    Article  Google Scholar 

  53. Worthington HV, Clarkson JE, Eden OB (2006) Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev:CD000978

    Google Scholar 

  54. Thiebaut A, Vernant JP, Degos L et al (2000) Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87. Hematol Oncol Clin North Am 14:1353-1366 x

    Article  PubMed  CAS  Google Scholar 

  55. Fiere D, Lepage E, Sebban C et al (1993) Adult acute lymphoblastic leukemia: a multicentric randomized trial testing bone marrow transplantation as postremission therapy. The French Group on Therapy for Adult Acute Lymphoblastic Leukemia. J Clin Oncol 11:1990-2001

    PubMed  CAS  Google Scholar 

  56. Ribera JM, Ortega JJ, Oriol A et al (1998) Late intensification chemotherapy has not improved the results of intensive chemotherapy in adult acute lymphoblastic leukemia. Results of a prospective multicenter randomized trial (PETHEMA ALL-89). Spanish Society of Hematology. Haematologica 83:222-230

    PubMed  CAS  Google Scholar 

  57. Gupta V, Yi QL, Brandwein J et al (2004) The role of allogeneic bone marrow transplantation in adult patients below the age of 55 years with acute lymphoblastic leukemia in first complete remission: A donor vs no donor comparison. Bone Marrow Transplant 33:397-404

    Article  PubMed  CAS  Google Scholar 

  58. Labar B, Suciu S, Zittoun R et al (2004) Allogeneic stem cell transplantation in acute lymphoblastic leukemia and non-Hodgkin’s lymphoma for patients ≤50 years old in first complete remission: results of the EORTC ALL-3 trial. Haematologica 89:809-817

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Haematology, Royal Free and University College Medical School, London, UK

    Bella Patel & Adele K. Fielding

  2. Department of Haematology, University College London Hospitals, London, UK

    Anthony H. Goldstone

Authors
  1. Bella Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anthony H. Goldstone
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Adele K. Fielding
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University Hospitals Case Medical Center, Cleveland, OH, USA

    Hillard M. Lazarus

  2. Case Western Reserve University, Cleveland, OH, USA

    Mary J. Laughlin

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Patel, B., Goldstone, A.H., Fielding, A.K. (2010). Allogeneic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia (ALL). In: Lazarus, H.M., Laughlin, M.J. (eds) Allogeneic Stem Cell Transplantation. Contemporary Hematology. Humana Press. https://doi.org/10.1007/978-1-59745-478-0_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-59745-478-0_3

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-934115-33-6

  • Online ISBN: 978-1-59745-478-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation