Skip to main content

Cardiovascular Imaging in Racial/Ethnic Populations: Implications for the Adequate Application of Cardiovascular Imaging Techniques Guided by Racial/Ethnic Risk Factor Variations

  • Chapter
Cardiovascular Disease in Racial and Ethnic Minorities

Part of the book series: Contemporary Cardiology ((CONCARD))

  • 641 Accesses

Abstract

Over the last decade, the increased research focus on cardiovascular imaging for the identification of patients at risk for and with significant coronary artery disease (CAD) has augmented clinician awareness and ability to properly risk stratify and categorize patients. Cardiac imaging has now become a technique not only for assessing patients with established CAD but also for the identification of patients with subclinical CAD who are at risk for ischemic heart disease and cardiac events of death and myocardial infarction. The Multi-Ethnic Study of Atherosclerosis (MESA) is a 10-year longitudinal study supported by the National Heart, Lung, and Blood Institute with the goals of identifying and quantifying risk factors for subclinical atherosclerosis, and for transition in patients from subclinical disease to clinically apparent events. Cardiac imaging findings from MESA with respect to racial/ethnic differences reveal that the incidence and prevalence of CAD differ among some racial/ethnic groups in the United States. The large number of patients affected by CAD has driven the development of effective, non-invasive methods to identify and risk-stratify patients with and at risk for CAD. When patients are properly identified, the appropriate treatment strategies can be applied to individual patients to prevent future events, such as death or myocardial infarction. Historically, exercise treadmill testing (ETT) with electrocardiogram (ECG) monitoring was the initial test applied to patients suspected of having CAD. Today, non-invasive cardiovascular testing with imaging has become the gold standard for the diagnostic and prognostic assessment of patients with suspected or known cardiovascular disease.

Most of the diagnostic non-invasive imaging tests currently available are based on assessment of regional and global function (echocardiography, radionuclide angiography, magnetic resonance imaging [MRI]), myocardial perfusion (single-photon emission computed tomography (CT), contrast-enhanced MRI), or coronary anatomy (CT angiography, magnetic resonance angiography) under resting conditions, stress conditions, or both. Diagnostic techniques such as electron beam CT, multi-slice cardiac CT scanning, and measurement of carotid intimal–medial thickness have emerged in recent years for detecting asymptomatic coronary or carotid atherosclerosis. Recent data on the assessment of long-term prognosis based upon the results of imaging tests to define false results has been shown to be reliable and helpful in risk prediction of cardiac events. In daily clinical practice, the assessment of risk allows for the identification of subsets of patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Heart Disease and Stroke Statistics—2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008; 117: e25–e146.

    Google Scholar 

  2. Bonow RO, Grant AO, Jacobs AK. The cardiovascular state of the union: confronting healthcare disparities. Circulation 2005; 111(10):1205–1207.

    Article  PubMed  Google Scholar 

  3. Bild D, Bluemke D, Burke G, et al. The Multi-Ethnic Study of Atherosclerosis (MESA): objectives and design. Am J Epidemiol 2002; 156:871–881.

    Article  PubMed  Google Scholar 

  4. Bild DE, Detrano R, Peterson D, et al. Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2005; 111(10):1313–1320.

    Article  PubMed  Google Scholar 

  5. McClelland RL, Chung H, Detrano R, Post W, Kronmal RA. Distribution of coronary artery calcium by race, gender, and age: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2006; 113(1):30–37.

    Article  PubMed  Google Scholar 

  6. McDermott MM, Liu K, Criqui MH, et al. Ankle-brachial index and subclinical cardiac and carotid disease: the multi-ethnic study of atherosclerosis. Am J Epidemiol 2005; 162(1):33–41.

    Article  PubMed  Google Scholar 

  7. Edvardsen T, Rosen BD, Pan L, et al. Regional diastolic dysfunction in individuals with left ventricular hypertrophy measured by tagged magnetic resonance imaging—The Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J 2006; 151(1): 109–114.

    Article  PubMed  Google Scholar 

  8. Li AE, Kamel I, Rando F, Anderson M, Kumbasar B, Lima JA, Bluemke DA. Using MRI to assess aortic wall thickness in the multiethnic study of atherosclerosis: distribution by race, sex, and age. Am J Roentgenol 2004; 182(3):593–597.

    Google Scholar 

  9. Wang L, Jerosch-Herold M, Jacobs DR Jr, Shahar E, Detrano R, Folsom AR. Coronary artery calcification and myocardial perfusion in asymptomatic adults. The MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 2006; 48(5): 1018–1026.

    Article  CAS  PubMed  Google Scholar 

  10. Centers for Disease Control and Prevention. The Third National health and Nutrition Survey, (NHANES III, 1988-94); www.cdc.gov/nchs/nhanes.htm.

  11. Cooper R, Cutler J, Desvigne-Nickens P, et al. Trends and disparities in coronary heart disease, stroke, and other cardiovascular diseases in the United States: findings of the national conference on cardiovascular disease prevention. Circulation 2000; 102(25):3137–3147.

    CAS  PubMed  Google Scholar 

  12. Jones DW, Chambless LE, Folsom AR, et al. Risk factors for coronary heart disease in African Americans: the atherosclerosis risk in communities study, 1987-1997. Arch Intern Med 2002; 162(22):2565–2571.

    Article  PubMed  Google Scholar 

  13. Beller GA. A proposal for an advanced cardiovascular imaging training track. J Am Coll Cardiol 2006; 48(7):1299–1303.

    Article  PubMed  Google Scholar 

  14. Klocke FJ, Baird MG, Bateman TM, et al. ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging– executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to Revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide Imaging). Circulation 2003; 108(11):1404–1418.

    Article  PubMed  Google Scholar 

  15. Cheitlin MD, Armstrong WF, Aurigemma GP, et al. ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography). Circulation 2003; 108(9):1146–1162.

    Article  PubMed  Google Scholar 

  16. Greenland P, Bonow RO, Brundage BH, et al. ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol 2007; 49(3):378–402.

    Article  PubMed  Google Scholar 

  17. Gibbons RJ, Balady GJ, Bricker JT, et al. ACC/AHA 2002 guideline update for exercise testing: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). Circulation 2002; 106(14):1883–1892.

    Article  PubMed  Google Scholar 

  18. Gibbons RJ, Abrams J, Chatterjee K, et al.; American College of Cardiology; American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable Angina). ACC/AHA 2002 guideline update for the management of patients with chronic stable angina–summary article: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on the Management of Patients with Chronic Stable Angina). J Am Coll Cardiol 2003; 41(1):159–168.

    Article  PubMed  Google Scholar 

  19. Mieres JH, Shaw LJ, Arai A, et al. Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease: consensus statement from the Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, Council on Cardiovascular Radiology and Intervention, American Heart Association. Circulation 2005; 111(5):682–696.

    Article  PubMed  Google Scholar 

  20. Mieres JH, Makaryus AN, Redberg RF, Shaw LJ. Noninvasive cardiac imaging. Am Fam Physician 2007; 75(8):1219–1228.

    PubMed  Google Scholar 

  21. Hachamovitch R, Berman DS, Kiat H, Cohen I, Friedman JD, Shaw LJ. Value of stress myocardial perfusion single photon emission computed tomography in patients with normal resting electrocardiograms: an evaluation of incremental prognostic value and cost-effectiveness. Circulation 2002; 105(7):823–829.

    Article  PubMed  Google Scholar 

  22. Eagle KA, Berger PB, Calkins H, et al. ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery–executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Anesth Analg 2002; 94(5):1052–1064.

    Article  PubMed  Google Scholar 

  23. Allman KC, Shaw LJ, Hachamovitch R, Udelson JE. Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J Am Coll Cardiol 2002; 39(7):1151–1158.

    Article  PubMed  Google Scholar 

  24. Hachamovitch R, Berman DS, Kiat H, et al. Exercise myocardial perfusion SPECT in patients without known coronary artery disease: incremental prognostic value and use in risk stratification. Circulation 1996; 93(5):905–914.

    CAS  PubMed  Google Scholar 

  25. Alkeylani A, Miller DD, Shaw LJ, et al. Influence of race on the prediction of cardiac events with stress technetium-99m sestamibi tomographic imaging in patients with stable angina pectoris. Am J Cardiol 1998; 81(3):293–297.

    Article  CAS  PubMed  Google Scholar 

  26. Akinboboye OO, Idris O, Onwuanyi A, Berekashvili K, Bergmann SR. Incidence of major cardiovascular events in black patients with normal myocardial stress perfusion study results. J Nucl Cardiol 2001; 8(5):541–547.

    Article  CAS  PubMed  Google Scholar 

  27. Shaw LJ, Hendel RC, Cerquiera M, et al. Ethnic differences in the prognostic value of stress technetium-99m tetrofosmin gated single-photon emission computed tomography myocardial perfusion imaging. J Am Coll Cardiol 2005; 45(9):1494–1504.

    Article  PubMed  Google Scholar 

  28. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999; 340(1):14–22.

    Article  PubMed  Google Scholar 

  29. Chapman JN, Mayet J, Chang CL, Foale RA, Thom SA, Poulter NR. Ethnic differences in the identification of left ventricular hypertrophy in the hypertensive patient. Am J Hypetens 1999; 12(5):437–442.

    Article  CAS  Google Scholar 

  30. Willens HJ, Chirinos JA, Hennekens CH. Prevalence and clinical correlates of mitral annulus calcification in Hispanics and non-Hispanic whites. J Am Soc Echocardiogr 2007; 20(2):191–196.

    Article  PubMed  Google Scholar 

  31. Zheng ZJ, Sharrett AR, Chambless LE, et al. Associations of ankle-brachial index with clinical coronary heart disease, stroke, and preclinical carotid and popliteal atherosclerosis: The Atherosclerosis Risk In Communities (ARIC) Study. Atherosclerosis 1997; 131:115–125.

    Article  CAS  PubMed  Google Scholar 

  32. Greenland P, LaBree L, Azen SP, Doherty TM, Detrano RC. Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA 2004; 291(2):210–215.

    Article  CAS  PubMed  Google Scholar 

  33. Budoff MJ, Yang TP, Shavelle RM, Lamont DH, Brundage BH. Ethnic differences in coronary atherosclerosis. J Am Coll Cardiol 2002; 39(3):408–412.

    Article  PubMed  Google Scholar 

  34. Nasir K, Shaw LJ, Liu ST, et al. Ethnic differences in the prognostic value of coronary artery calcification for all-cause mortality. J Am Coll Cardiol 2007; 50(10):953–960.

    Article  PubMed  Google Scholar 

  35. Budoff MJ, Achenbach S, Duerinckx A. Clinical utility of computed tomography and magnetic resonance techniques for noninvasive coronary angiography. J Am Coll Cardiol 2003; 42:1867–1878.

    Article  PubMed  Google Scholar 

  36. Nagel E, Klein C, Paetsch I, et al. Magnetic resonance perfusion measurements for the noninvasive detection of coronary artery disease. Circulation 2003; 108:432–437.

    Article  PubMed  Google Scholar 

  37. Natori S, Lai S, Finn JP, et al. Cardiovascular function in multi-ethnic study of atherosclerosis: normal values by age, sex, and ethnicity. AJR Am J Roentgenol 2006; 186(6 Suppl. 2):S357–S365.

    Article  PubMed  Google Scholar 

  38. Douglas PS. Is noninvasive testing for coronary artery disease accurate? Circulation 1997; 95:299–302.

    CAS  PubMed  Google Scholar 

  39. Shaw LJ, Bairey Merz CN, Pepine CJ, et al. Insights from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part I: gender differences in traditional and el risk factors, symptom evaluation, and gender-optimized diagnostic strategies. J Am Coll Cardiol 2006; 47(3 Suppl.):S4–S20.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Makaryus, A.N., Mieres, J.H., Shaw, L.J. (2009). Cardiovascular Imaging in Racial/Ethnic Populations: Implications for the Adequate Application of Cardiovascular Imaging Techniques Guided by Racial/Ethnic Risk Factor Variations. In: Ferdinand, K.C., Armani, A. (eds) Cardiovascular Disease in Racial and Ethnic Minorities. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-410-0_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-59745-410-0_12

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-981-9

  • Online ISBN: 978-1-59745-410-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics