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Skeletal Trauma and Common Orthopedic Problems

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Bone Pathology

Abstract

Our understanding of the biology of fracture healing has evolved over the decades and basic science research as well as clinical outcomes studies continue to add to the existing knowledge. This review outlines the physiology and pathology of healing of fractures including those in children as well as fracture configurations with basic modalities of fixation and treatment.

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References

  1. Kleinman PK, Marks SC. The metaphyseal lesion in abused infants: a radiologic-histopathologic study. Am J Roentgenol 1986; 146: 895–905.

    CAS  Google Scholar 

  2. Nelson Textbook of Pediatrics. Part XXXI – Bone and Joint Disorders, Section 1: Orthopaedic Problems 2008; 18: 2771–811

    Google Scholar 

  3. Rang M. Rang’s Children’s Fractures. 3rd ed. Lippincott, Philadelphia, 2005.

    Google Scholar 

  4. Liu SH, Yang R, Al-Shaik R, et al. Collagen in tendon, ligament and bone healing. Clin Orthop Rel Res 1995; 318: 265–78.

    Google Scholar 

  5. Lynch SE, Buser D, Hernandez RA, et al. Effects of platelet derived growth factor/insulin like growth factor 1 combination on bone regeneration around titanium dental implants. J Periodontol 1991; 62: 710–6.

    Article  PubMed  CAS  Google Scholar 

  6. Lynch SE, DeCastill GR, Williams RC, et al. The effect of short term application of platelet derived and insulin like growth factors on peridontal wound healing. J Periodontol 1991; 62: 458–67.

    Article  PubMed  CAS  Google Scholar 

  7. Andrew JG, Hoyland J, Andrew SM, et al. Demonstration of TGF-beta1 mRNA by in situ hybridization in normal human fracture healing. Calcif Tissue Int 1993; 52: 74–8.

    Article  PubMed  CAS  Google Scholar 

  8. McQueen MM, Gaston P, Court-Brown CM. 2000; Acute compartment syndrome: who is at risk? JBJS(B) 82: 200–3.

    Article  CAS  Google Scholar 

  9. Geerts WH, Code KI, Jay RM, et al. A prospective study of venous thromboembolism after major trauma. N Engl J Med 1994; 331: 1601–6.

    Article  PubMed  CAS  Google Scholar 

  10. Holbein O, Neidlinger-Wilke C, Suger G, et al. Ilizarov callus distraction produces systemic bone cell mitogens. J Orthop Res 1995; 13: 629–38.

    Article  PubMed  CAS  Google Scholar 

  11. Gelberman RH, Amiel D, Harwood F. Genetic expression for type I procollagen in the early stages of flexor tendon healing. J Hand Surg 1992; 17A: 551–8.

    Google Scholar 

  12. Amiel D, Kleiner JB, Doux RD, et al. The phenomenon of ligamentization: anterior cruciate ligament reconstruction with autogenous patellar tendon. J Orthop Res 1986; 4: 162–72.

    Article  PubMed  CAS  Google Scholar 

  13. Einhorn TA. Enhancement of fracture healing. JBJS(A) 1995; 77: 940–56.

    CAS  Google Scholar 

  14. Cook SD, Wolfe MW, Salkeld SL, et al. Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. JBJS(A) 1995; 77(5): 734–50.

    Google Scholar 

  15. Bentz H, Thompson AY, Armstrong R, et al. Transforming growth factor-beta 2 enhances the osteoinductive activity of a bovine bone derived fraction containing bone morphogenetic protein-2 and protein-3. Matrix 1991; 11: 269–75.

    PubMed  CAS  Google Scholar 

  16. Page M, Hogg J, Ashhurst DE. The effects of mechanical stability on the macromolecules of the connective tissue matrices produced during fracture healing. I: The collagens. Histochem J 1986; 18: 251–65.

    Article  PubMed  CAS  Google Scholar 

  17. Page M, Ashhurst DE. The effects of mechanical stability on the macromolecules of the connective tissue matrices produced during fracture healing. II: The glycosaminoglycans. Histochem J. 1987; 19: 39–61.

    Article  PubMed  CAS  Google Scholar 

  18. Wolff J. Das Gaesetz der Transformation der Knochen. Hirchwald, Berlin, 1892.

    Google Scholar 

  19. Sarmiento A, Schaeffer JF, Beckerman L, et al. Fracture healing in rat femora as affected by functional weight-bearing. JBJS(A) 1994; 76: 820–6.

    Google Scholar 

  20. Riggins RS, Simanonok C, Lewis DW, et al. Weight bearing: its lack of effect on fracture healing. Int Orthop 1985; 9: 199–203.

    Article  PubMed  CAS  Google Scholar 

  21. Kirchen ME, O’Conner KM, Gruber HE, et al. Effects of microgravity on bone healing in a rat fibular osteotomy model. Clin Orthop Relat Res 1995; 318: 231–42.

    PubMed  Google Scholar 

  22. Blenman PR, Carter DR, Beupre GS. Role of mechanical loading in the progressive ossification of a fracture callus. J Orthop Res 1989; 7: 398–407.

    Article  PubMed  CAS  Google Scholar 

  23. Carter DR, Blenman PR, Beupre GS. Correlation between mechanical stress history and tissue differentiation in initial fracture healing. J Orthop Res 1988; 6: 736–48.

    Article  PubMed  CAS  Google Scholar 

  24. Goodship AE, Kenwright J. The influence of induced micromovement upon the healing of experimental tibial fractures. JBJS(B) 1985; 67: 650–5.

    CAS  Google Scholar 

  25. Duarte LR. The stimulation of bone growth by ultrasound. Arch Orthop Trauma Surg 1983; 101: 153–9.

    Article  PubMed  CAS  Google Scholar 

  26. Kjaerssgaard-Anderson P, Ritter MA. Prevention of formation of heterotopic bone after total hip arthroplasty: current concepts review. JBJS(A) 1991; 73: 942–7.

    Google Scholar 

  27. Doury P. Bone marrow oedema, transient osteoporosis and algodystrohy. JBJS(B) 1994; 76: 993–4.

    CAS  Google Scholar 

  28. Wenger DR, Ward WT, Herring JA. Legg-Calve-Perthes disease – current concepts review. JBJS(A) 1991; 73: 778–88.

    CAS  Google Scholar 

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Hosalkar, H.S., Torbert, J.T., Goebel, J., Khurana, J.S. (2009). Skeletal Trauma and Common Orthopedic Problems. In: Khurana, J. (eds) Bone Pathology. Humana Press. https://doi.org/10.1007/978-1-59745-347-9_10

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  • DOI: https://doi.org/10.1007/978-1-59745-347-9_10

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  • Print ISBN: 978-1-58829-766-2

  • Online ISBN: 978-1-59745-347-9

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