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Natural History of HPV Infection in Adolescents and Relationship to Cervical Cancer

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Molecular Pathology of Gynecologic Cancer

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Cervical cytology screening programs have led to a decrease in the incidence and mortality of cervical cancer in the United States and other developed countries. Following the discovery of Human papillomavirus (HPV) as a potential cause of cervical cancer in the 1970s (1), subsequent epidemiological studies utilized sensitive HPV-DNA detection techniques to assess the prevalence of this virus in populations of all ages. Populations with a high prevalence of HPV infection were the same ones identified in earlier studies as being at high risk of developing cervical cancer. These included women who were young when they initiated sexual intercourse, had multiple sexual partners, and had other sexually transmitted infections (STIs) (2). Several studies in the 1980s also reported that adolescents in the United States had very high rates of unprotected sexual intercourse, STIs, and multiple sexual partners (3). Similarly, women in this age group had high rates of HPV infection (4,5).

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Author information

Authors and Affiliations

  1. Division of Adoloscent Medicine, Department of Pediatrics, School of Medicine, University of California at San Francisco, San Francisco, CA

    Anna-Barbara Moscicki MD

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  1. Anna-Barbara Moscicki MD
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Editors and Affiliations

  1. Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA

    Antonio Giordano MD, PhD  & Alessandro Bovicelli MD, PhD  & 

  2. Departments of Human Pathology and Oncology, University of Siena, Siena, Italy

    Antonio Giordano MD, PhD

  3. Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy

    Alessandro Bovicelli MD, PhD

  4. Departments of Gynecology-Obstetrics and Pathology, Johns Hopkins University, Baltimore, MD

    Robert J. Kurman MD, PhD

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© 2007 Humana Press Inc., Totowa, NJ

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Moscicki, AB. (2007). Natural History of HPV Infection in Adolescents and Relationship to Cervical Cancer. In: Giordano, A., Bovicelli, A., Kurman, R.J. (eds) Molecular Pathology of Gynecologic Cancer. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-59745-346-2_7

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  • DOI: https://doi.org/10.1007/978-1-59745-346-2_7

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-453-1

  • Online ISBN: 978-1-59745-346-2

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