Abstract
Consuming polyunsaturated fatty acids instead of saturated fat has been advocated for many years now, in an attempt to lower blood cholesterol and reduce atherosclerotic disease. In Israel, there is a high intake of ω6 fatty acids, a low total and trans fat intake, a high fruit and vegetable intake-but a similar prevalence of chronic diseases as in the rest of the western world. This Israeli paradox is probably due to the too-high intake of ω6 fatty acids, which can promote insulin resistance, increased atherogenesis and thrombosis, coronary events and cancer. Increasing ω3 fatty acid intake, by modifying fat content in foods and public education, seems a plausible way of raising the ω6:ω3 fatty acid ratio and lowering the rate of chronic diseases, in a population consuming a diet rich in ω6 fat.
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References
Dubnov G, Berry EM. Omega-6 fatty acids and coronary artery disease: the pros and cons. Curr Atheroscler Rep 2004;6:441–446.
Berry EM. Are diets high in omega 6 polyunsaturated fatty acids unhealthy? Eur Heart J Supplements 2001;39(supplD):D37–D41.
Berry EM. Who’s afraid of n-6 polyunsaturated fatty acids? Methodological considerations for assessing whether they are harmful. Nut Met Cardiovasc Dis 2001;11:181–188.
Okuyama H, Kobayashi T, Watanabe S. Dietary fatty acids—the n-6:n-3 balance and chronic elderly diseases. Excess linoleic acid and relative ω3 deficiency syndrome seen in Japan. Prog Lipid Res 1997;35:409–457.
Grundy AM. Evaluation of publicly available scientific evidence regarding certain nutrientdisease relationships: Lipids and cardiovascular disease. Life Sciences Research Office. Federation of American Societies for Experimental Biology. Bethesda, MD, 1991.
Dewailly E, Blanchet C, Lemieux S, et al. ω3 fatty acids and cardiovascular disease risk factors among the Inuit of Nunavik. Am J Clin Nutr 2001;74:464–473.
Albert CM, Campos H, Stampfer MJ, et al. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med 2002;346:1113–1118.
Hu FB, Bronner L, Willett WC, et al. Fish and omega 3 fatty acid intake and risk of coronary heart disease in women. JAMA 2002;287:1815–1821.
Albert CM, Gaziano JM, Willett WC, Manson JE. Nut consumption and decreased risk of sudden cardiac death in the Physicians’ Health Study. Arch Intern Med 2002; 162:1382–1387.
Hu FB, Stampfer MJ, Manson JE, et al. Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study. BMJ 1998;317:1341–1345.
Hu FB, Stampfer MJ, Manson JE, et al. Dietary intake of alpha-linolenic acid and risk of ischemic heart disease among women. Am J Clin Nutr 1999;69:890–897.
De Lorgeril M, Salen P, Martin J-L, et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 1999;99:779–785.
GISSI-Prevenzione Investigators. Dietary supplementation with ω3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999;354:447–455.
Bucher HC, Hengstler P, Schindler C, Meier G. ω3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 2002; 112:298–304.
de Deckere EAM, Korver O, Verschuren PM, Katan MB. Health aspects of fish and ω3 polyunsaturated fatty acids from plant and marine origin. Eur J Clin Nutr 1998;52:749–753.
Leaf A, Albert CM, Josephson M, et al. Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation 2005;112:2762–2768.
Iso H, Kobayashi M, Ishihara J, et al. Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation 2006;113:195–202.
Erkkila AT, Lehto S, Pyorala K, Uusitupa MI. n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. Am J Clin Nutr 2003;78:65–71.
Hooper L, Thompson RL, Harrison RA, et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ 2006;332:752–760.
Burr ML, Ashfield-Watt PA, Dunstan FD, et al. Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clin Nutr 2003;57:193–200.
Raitt MH, Connor WE, Morris C, et al. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA 2005;293:2884–2891.
Jarvinen R, Knekt P, Rissanen H, Reunanen A. Intake of fish and long-chain n-3 fatty acids and the risk of coronary heart mortality in men and women. Br J Nutr 2006;95:824–829.
Brouwer IA, Heeringa J, Geleijnse JM, Zock PL, Witteman JC. Intake of very long-chain n-3 fatty acids from fish and incidence of atrial fibrillation. The Rotterdam Study. Am Heart J 2006; 151:857–862.
Yam D, Eliraz A, Berry EM. Diet and disease-the Israeli paradox: possible dangers of a high omega 6 polyunsaturated fatty acid diet. Isr J Med Sci 1996;32:1134–1143.
Kark JD, Kaufmann NA, Binka F, Goldberger N, Berry EM. Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. Am J Clin Nutr 2003;77:796–802.
Enig MG, Budowski P, Blondheim SH. Trans-unsaturated fatty acids in margarines and human subcutaneous fat in Israel. Hum Nutr Clin Nutr 1984;38:223–230.
Kardinaal AF, Aro A, Kark JD, et al. Association between beta-carotene and acute myocardial infarction depends on polyunsaturated fatty acid status. The EURAMIC Study. European study on antioxidants, myocardial infarction, and cancer of the breast. Arterioscler Thromb Vasc Biol 1995;15:726–732.
MABAT First Israeli national Health and Nutrition Survey 1999–2001 Part 2-What Israelis Eat. Food and Nutrition Services, Ministry of Health and Israel Center for Disease Control, Ministry of Health. Publication no. 228, 2004.
Guggenheim K, Kaufmann NA. Nutritional health in a changing societystudies from Israel. World Rev Nutr Diet 1976;2:217–240.
MABAT First Israeli national Health and Nutrition Survey 1999–2001 Part 1-General Findings. Food and Nutrition Services, Ministry of Health and Israel Center for Disease Control, Ministry of Health, Publication no. 225, 2003.
Kris-Etherton PM, Taylor DS, Yu-Poth S, et al. Polyunsaturated fatty acids in the food chain in the United States. Am J Clin Nutr 2000;71:179–188.
Sanders TAB. Polyunsaturated fatty acids in the food chain in Europe. Am J Clin Nutr 2000; 71(suppl):176S–178S.
Sugano M, Hirahara F. Polyunsaturated fatty acids in the food chain in Japan. Am J Clin Nutr 2000; 71:189–196.
Dubnov G, Berry EM. Omega 6:omega 3 fatty acid ratio: the Israeli paradox. World Rev Nutr Diet 2003;92:81–91.
World Health Organization. Diet, nutrition, and the prevention of chronic diseases. Technical report Series No. 916, 2003.
Australian Institute of Health and Welfare. International healthhow Australia compares. AIHW cat. no. PHE 8. Canberra: AIHW. 1998. Available at http://www.aihw.gov.au/publications/health/ihhac. Accessed April 1, 2006.
Kaufmann NA, Dennis BH, Heiss G, Friedlander Y, Kark JD, Stein Y. Comparison of nutrient intake of selected populations in the United States and Israel: the Lipid Research Clinics Prevalence Study. Am J Clin Nutr 1986;43:604–620.
Serdula MK, Gillespie C, Kettel-Khan L, Farris R, Seymour J, Denny C. Trends in fruit and vegetable consumption among adults in the United States: Behavioral Risk Factor Surveillance System, 1994–2000. Am J Public Health 2004;94:1014–1018.
Kark JD, Goldberger N, Fink R, Adler B, Kuulasmaa K, Goldman S. Myocardial infarction occurrence in Jerusalem: a Mediterranean anomaly. Atherosclerosis 2005;178:129–138.
Health Information Services, Israel Ministry of Health., Available at http://www.health. gov.il/units/healthisrael/63.htm and http://www.health.gov.il/units/healthisrael/62.htm. Accessed April 1, 2006.
Mokdad A, Ford ES, Bowman BA, et al. Diabetes Trends in the U.S.: 1990–1998. Diabetes Care 2000;23:1278–1283.
Dubnov G, Berry EM. Polyunsaturated fatty acids, insulin resistance, and atherosclerosis: is inflammation the connecting link? Metabol Synd Related Disord 2004;2:124–128.
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Dubnov-Raz, G., Berry, E.M. (2008). High ω6:ω3 Fatty Acid Ratio. In: De Meester, F., Watson, R.R. (eds) Wild-Type Food in Health Promotion and Disease Prevention. Humana Press. https://doi.org/10.1007/978-1-59745-330-1_3
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DOI: https://doi.org/10.1007/978-1-59745-330-1_3
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