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Intracellular Pathways Involved in DNA Damage and Repair to Neuronal Apoptosis

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Apoptosis, Cell Signaling, and Human Diseases

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Summary

One of the most well known connections between abnormalities of the DNA damage response and neurodegeneration has been the human syndrome of ataxia telangiectasia. However, other syndromes associated with defective DNA damage response also include neurological symptoms as a primary feature of their phenotypes. This argues that defects in the repair of, or response to, DNA damage impact significantly on brain function. This chapter summarizes some recent data underlying the contribution to neuronal function and dysfunction of at least two transcription factors known to be involved in DNA damage sensing and repairing: the tumor suppressor p53 and the component of the DNA mismatch repair system MSH2. Both proteins participate in the cancer prevention machinery for the body as well as in the neurodegenerative process.

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Authors and Affiliations

  1. Department of Biomedical Sciences and Biotechnologies, University of Brescia Medical School, Brescia, Italy

    Maurizio Memo PhD

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  1. Maurizio Memo PhD
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Editors and Affiliations

  1. Department of Biochemistry, University of Texas Health Center at Tyler, Tyler, TX

    Rakesh Srivastava

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© 2006 Humana Press Inc., Totowa, NJ

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Memo, M. (2006). Intracellular Pathways Involved in DNA Damage and Repair to Neuronal Apoptosis. In: Srivastava, R. (eds) Apoptosis, Cell Signaling, and Human Diseases. Humana Press. https://doi.org/10.1007/978-1-59745-199-4_16

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