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Apoptosis Induction in T Lymphocytes by HIV

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Apoptosis, Cell Signaling, and Human Diseases

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Summary

Infection with human immunodeficiency virus (HIV) is characterized by a progressive decrease in CD4+ T-cell number with a consequent impairment of the immune response and the onset of opportunistic infections and neoplasms. The mechanism responsible of CD4 T-cell depletion is mainly the induction of apoptosis, which can be activated by HIV through various pathways. In this chapter direct and indirect mechanisms of HIV-induced apoptosis in infected and uninfected bystander cells are described.

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Authors and Affiliations

  1. Department of Environmental Science, La Tuscia University, Viterbo, Italy

    Maria Saveria & Gilardini Montani

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  1. Maria Saveria
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  2. Gilardini Montani
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  1. Department of Biochemistry, University of Texas Health Center at Tyler, Tyler, TX

    Rakesh Srivastava

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© 2006 Humana Press Inc., Totowa, NJ

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Saveria, M., Montani, G. (2006). Apoptosis Induction in T Lymphocytes by HIV. In: Srivastava, R. (eds) Apoptosis, Cell Signaling, and Human Diseases. Humana Press. https://doi.org/10.1007/978-1-59745-199-4_14

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