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Endoscopic Ultrasound for Staging Gastric Cancer

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Endoscopic Oncology
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Abstract

Although the incidence of gastric cancer is declining, it remains a leading cause of cancer-related death worldwide. Prognosis in gastric cancer is highly correlated with tumor stage. Surgical therapy remains the definitive therapy. Accurate pre-operative staging is essential, especially in patients who may be marginal surgical candidates. Accurate staging also is of particular importance in early gastric cancer in which select lesions confined to the mucosa may be treated with local endoscopic mucosal resection. Endoscopic ultrasound (EUS) currently is the most accurate test in the local-regional staging of gastric cancer. Advanced gastric cancers should be staged with a combination of EUS and computed tomography (CT). Local therapy can be appropriately applied to early gastric cancers that have no nodal involvement and are limited to the muscularis mucosa. The additional use of EUS-fine-needle aspiration (FNA) for lymph nodes distant from the primary tumor may improve staging accuracy.

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References

  1. Caletti G, Ferrari A, Brocchi E, Barbara L. Accuracy of endoscopic ultrasonography in the diagnosis and staging of gastric cancer and lymphoma. Surgery 1993; 113:14–27.

    PubMed  CAS  Google Scholar 

  2. Nishi M, Omori Y, Miwa K, Japanese classification of gastric carcinoma. Japanese Research Society for Gastric Cancer. 1st edn. Tokyo: Kanehara & Co., 1995.

    Google Scholar 

  3. Hermanek P, Sobin LH, editors. UICC TNM classification of malignant tumors. 4th edition. Berlin: Springer; 1987.

    Google Scholar 

  4. Sobin LH, Wittekin CH. TNM classification of malignant tumors. International Union Against Cancer. 5th edn. New York: John Wiley & Sons; 1997.

    Google Scholar 

  5. Katai H,Yoshimura K, Maruyama K, Sasako M, Sano T. Evaluation of the New International Union Against Cancer TNM staging for gastric carcinoma. Cancer 2000; 88:1796–1800.

    Article  PubMed  CAS  Google Scholar 

  6. Hayashi H, Ochiai T, Suzuki T, et al. Superiority of a new UICC-TNM staging system for gastric carcinoma. Surgery 2000; 127:129–135.

    Article  PubMed  CAS  Google Scholar 

  7. Roder JD, Bottcher K, Busch R,Wittekind C, Hermanek P, Siewert JR. Classification of regional lymph node metastasis from gastric carcinoma. German Gastric Cancer Study Group. Cancer 1998; 82:621–631.

    Article  PubMed  CAS  Google Scholar 

  8. Yoo CH, Noh SH, Kim YI, Min JS. Comparison of prognostic significance of nodal staging between old (4th edition) and new (5th edition) UICC TNM classification for gastric carcinoma. International Union Against Cancer. World J Surg 1999; 23:492–497; discussion 497-498.

    Article  PubMed  CAS  Google Scholar 

  9. Hermanek P, Altendorf-Hofmann A, Mansmann U, Dworak O, Wittekind C, Hohenberger W. Improvements in staging of gastric carcinoma from using the new edition of TNM classification. Eur J Surg Oncol 1998; 24:536–541.

    Article  PubMed  CAS  Google Scholar 

  10. Murata Y, Suzuki S, Hashimoto H. Endoscopic ultrasonography of the upper gastrointestinal tract. Surg Endosc 1988; 2:180–183.

    Article  PubMed  CAS  Google Scholar 

  11. Tio TL, Schouwink MH, Cikot RJ, Tytgat GN. Preoperative TNM classification of gastric carcinoma by endosonography in comparison with the pathological TNM system: a prospective study of 72 cases. Hepatogastroenterology 1989; 36:51–56.

    PubMed  CAS  Google Scholar 

  12. Akahoshi K, Misawa T, Fujishima H, Chijiiwa Y, Maruoka A, Ohkubo A, Nawata H. Preoperative evaluation of gastric cancer by endoscopic ultrasound. Gut 1991; 32:479–482.

    Article  PubMed  CAS  Google Scholar 

  13. Botet JF, Lightdale CJ, Zauber AG, Gerdes H, Winawer SJ, Urmacher C, Brennan MF. Preoperative staging of gastric cancer: comparison of endoscopic US and dynamic CT. Radiology 1991; 181:426–432.

    PubMed  CAS  Google Scholar 

  14. Dittler HJ, Siewert JR. Role of endoscopic ultrasonography in gastric carcinoma. Endoscopy 1993; 25:162–166.

    PubMed  CAS  Google Scholar 

  15. Grimm H, Binmoeller KF, Hamper K, Koch J, Henne-Bruns D, Soehendra N. Endosonography for preoperative locoregional staging of esophageal and gastric cancer. Endoscopy 1993; 25:224–230.

    PubMed  CAS  Google Scholar 

  16. Ziegler K, Sanft C, Zimmer T, et al. Comparison of computed tomography, endosonography, and intraoperative assessment in TN staging of gastric carcinoma. Gut 1993; 34:604–610.

    Article  PubMed  CAS  Google Scholar 

  17. Massari M, Cioffi U, De Simone M, et al. Endoscopic ultrasonography for preoperative staging of gastric carcinoma. Hepatogastroenterology 1996; 43:542–546.

    PubMed  CAS  Google Scholar 

  18. Perng DS, Jan CM, Wang WM, et al. Computed tomography, endoscopic ultrasonography and intraoperative assessment in TN staging of gastric carcinoma. J Formos Med Assoc 1996; 95:378–385.

    PubMed  CAS  Google Scholar 

  19. Wang JY, Hsieh JS, Huang YS, Huang CJ, Hou MF, Huang TJ. Endoscopic ultrasonography for preoperative locoregional staging and assessment of resectability in gastric cancer. Clin Imaging 1998; 22:355–359.

    Article  PubMed  CAS  Google Scholar 

  20. Tseng LJ, Mo LR, Tio TL, et al. Video-endoscopic ultrasonography in staging gastric carcinoma. Hepatogastroenterology 2000; 47: 897–900.

    PubMed  CAS  Google Scholar 

  21. Willis S, Truong S, Gribnitz S, Fass J, Schumpelick V. Endoscopic ultrasonography in the preoperative staging of gastric cancer: accuracy and impact on surgical therapy. Surg Endosc 2000;14: 951–954.

    Article  PubMed  CAS  Google Scholar 

  22. Habermann CR, Weiss F, Riecken R, et al. Preoperative staging of gastric adenocarcinoma: comparison of helical CT and endoscopic US. Radiology 2004; 230:465–471.

    Article  PubMed  Google Scholar 

  23. Yanai H, Matsumoto Y, Harada T, et al. Endoscopic ultrasonography and endoscopy for staging depth of invasion in early gastric cancer: a pilot study. Gastrointest Endosc 1997; 46:212–216.

    Article  PubMed  CAS  Google Scholar 

  24. Waneb HJ, Kennedy BJ, Chmiel J, Steele G Jr, Winchester D, Osteen R. Cancer of the stomach. A patient care study by the American College of Surgeons. Ann Surg 1993; 218:583–592.

    Article  Google Scholar 

  25. Chen CH, Yang CC, Yeh YH. Preoperative staging of gastric cancer by endoscopic ultrasound: the prognostic usefulness of ascites detected by endoscopic ultrasound. J Clin Gastroenteroln 2002; 35:321–327.

    Article  Google Scholar 

  26. Chu KM, Kwok KF, Law S, Wong KH. A prospective evaluation of catheter probe EUS for the detection of ascites in patients with gastric carcinoma. Gastrointest Endosc 2004; 59:471–474.

    Article  PubMed  Google Scholar 

  27. Meining A, Dittler HJ, Wolf A, et al. You get what you expect? A critical appraisal of imaging methodology in endosonographic cancer staging. Gut 2002; 50:599–603.

    Article  PubMed  CAS  Google Scholar 

  28. Meining A, Rosch T, Wolf A, et al. High interobserver variability in endosonographic staging of upper gastrointestinal cancers. Z Gastroenterol 2003; 41:391–394.

    Article  PubMed  CAS  Google Scholar 

  29. Ichikura T, Uefuji K, Tomimatsu S, Okusa Y, Yahara T, Tamakuma S. Surgical strategy for patients with gastric carcinoma with submucosal invasion. A multivariate analysis. Cancer 1995; 76: 935–940.

    Article  PubMed  CAS  Google Scholar 

  30. Akahoshi K, Chijiwa Y, Hamada S, et al. Pretreatment staging of endoscopically early gastric cancer with a 15 MHz ultrasound catheter probe. Gastrointest Endosc 1998; 48:470–476.

    Article  PubMed  CAS  Google Scholar 

  31. Yanai H, Tada M, Karita M, Okita K. Diagnostic utility of 20-mega-hertz linear endoscopic ultrasonography in early gastric cancer. Gastrointest Endosc 1996; 44:29–33.

    Article  PubMed  CAS  Google Scholar 

  32. Okamura S, Tsutsui A, Muguruma N, et al. The utility and limitations of an ultrasonic miniprobe in the staging of gastric cancer. J Med Invest 1999; 46:49–53.

    PubMed  CAS  Google Scholar 

  33. Yanai H, Noguchi T, Mizumachi S, et al. A blind comparison of the effectiveness of endoscopic ultrasonography and endoscopy in staging early gastric cancer. Gut 1999; 44:361–365.

    Article  PubMed  CAS  Google Scholar 

  34. Akahoshi K, Chijiiwa Y, Sasaki I, et al. Pre-operative TN staging of gastric cancer using a 15 MHz ultrasound miniprobe. Br J Radiol 1997; 70:703–707.

    PubMed  CAS  Google Scholar 

  35. Hunerbein M, Ghadimi BM, Haensch W, Schlag PM. Transendoscopic ultrasound of esophageal and gastric cancer using miniaturized ultrasound catheter probes. Gastrointest Endosc 1998; 48:371–375.

    Article  PubMed  CAS  Google Scholar 

  36. Mortensen MB, Pless T, Durup J, Ainsworth AP, Plagborg GJ, Hovendal C. Clinical impact of endoscopic ultrasound-guided fine needle aspiration biopsy in patients with upper gastrointestinal tract malignancies. A prospective study. Endoscopy 2001; 33:478–483.

    Article  PubMed  CAS  Google Scholar 

  37. Chang KJ, Albers CG, Nguyen P. Endoscopic ultrasound-guided fine needle aspiration of pleural and ascetic fluid. Am J Gastroenterol 1995;90(1):148–150.

    PubMed  CAS  Google Scholar 

  38. ten Berge J, Hoffman BJ, Hawes RH, et al. EUS-guided fine needle aspiration of the liver: indications, yield, and safety based on an international survey of 167 cases. Gastrointest Endosc 2002; 55:859–862

    Article  Google Scholar 

  39. Chen TK, Wu CH, Lee CL, Lai YC, Yang SS. Endoscopic ultrasonography in the differential diagnosis of giant gastric folds. J Formos Med Assocm 1999; 98:261–264.

    CAS  Google Scholar 

  40. Caletti G, Fusaroli P, Bocus P. Endoscopic ultrasonography in large gastric folds. Endoscopy 1998; 30 Suppl 1:A72–A75.

    Google Scholar 

  41. Mendis RE, Gerdes H, Lightdale CJ, Botet JF. Large gastric folds: a diagnostic approach using endoscopic ultrasonography. Gastrointest Endosc 1994; 40:437–441.

    Article  PubMed  CAS  Google Scholar 

  42. Songur Y, Okai T, Watanabe H, Motoo Y, Sawabu N. Endosonographic evaluation of giant gastric folds. Gastrointest Endosc 1995; 41: 468–474.

    Article  PubMed  CAS  Google Scholar 

  43. Fujishima H, Misawa T, Chijiwa Y, Maruoka A, Akahoshi K, Nawata H. Scirrhous carcinoma of the stomach versus hypertrophic gastritis: findings at endoscopic US. Radiology 1991; 181:197–200.

    PubMed  CAS  Google Scholar 

  44. Saito N, Takeshita K, Habu H, Endo M. The use of endoscopic ultrasound in determining the depth of cancer invasion in patients with gastric cancer. Surg Endosc 1991; 5:14–19.

    Article  PubMed  CAS  Google Scholar 

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© 2006 Humana Press, Totowa, NJ

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Olds, G., Chak, A. (2006). Endoscopic Ultrasound for Staging Gastric Cancer. In: Faigel, D.O., Kochman, M.L. (eds) Endoscopic Oncology. Humana Press. https://doi.org/10.1007/978-1-59745-172-7_11

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  • DOI: https://doi.org/10.1007/978-1-59745-172-7_11

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-532-3

  • Online ISBN: 978-1-59745-172-7

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