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Current and Emerging Mass Spectrometry Instrumentation and Methods for Proteomic Analyses

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Cancer Proteomics

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Summary

The dynamic nature of the mass spectrometry (MS) experiment creates many opportunities for innovation and advance. The new ion generation methods that merited the Nobel Prize were especially revolutionary examples, but mass analyzer design, ion chemistry, ion detection, and data analysis have all seen significant performance advances. In the area of proteomics, the key moment for any of these innovations and advances comes when they are transferred from MS laboratory to the biomedical research laboratory. Indeed, the past 5 or so years have seen key aspects of electrospray and matrix-assisted laser desorption/ionization mature to the point that MS is now ubiqitous part of life science research and experiments that were once cutting edge have become routine. Similarly, the new methods described in this chapter are also beginning to pass this transfer test to produce unique results in a variety of biological systems.

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References

  1. Nobelprize.org. Nobel prize in Chemistry 2002.

    Google Scholar 

  2. Stafford, G. Jr. J. Am. Soc. Mass Spectrom. 13:589–596, 2002.

    PubMed  CAS  Google Scholar 

  3. Jonscher, K.R., Yates, J.R. III. Anal. Biochem. 244:1–15, 1997.

    PubMed  CAS  Google Scholar 

  4. Schwartz, J.C., Senko, W.W., Syka, J.E. J. Am. Soc Mass Spectrom. 13:659–669, 2002.

    PubMed  CAS  Google Scholar 

  5. Viveka, M., Rezaul, K., Cong, Y.S., Han, D. Mol. Cell. Proteomics 4:214–223, 2005.

    Google Scholar 

  6. Syka, J.E., Marto, J.A., Bai, D.L., Horning, S., Senko, M.W., Schwartz, J.C., Ueberheide, B., Garcia, B., Busby, S., Muratore, T., Shabanowitz, J., Hunt, D.F. J. Proteome Res. 3:621–626, 2004.

    PubMed  CAS  Google Scholar 

  7. McCormack, A.L., Schieltz, D.M., Goode, B., Yang, S., Barnes, G., Drubin, D., Yates J.R. III. Anal. Chem. 69:767–776, 1997.

    PubMed  CAS  Google Scholar 

  8. Washburn, M.P., Wolters, D., Yates, J.R. III. Nat. Biotechnol. 19:242–247, 2001.

    PubMed  CAS  Google Scholar 

  9. Elias, J.E., Haas, W., Faherty, B.K., Gygi, S.P. Nat. Methods 2:667–675, 2005.

    PubMed  CAS  Google Scholar 

  10. Plymoth, A., Yang, Z., Lofdahl, C.G., Ekberg-Jansson, A., Dahlback, M., Fehniger, T.E., Marko-Varga, G., Hancock, W.S. Clin. Chem. 52:671–679, 2006.

    PubMed  CAS  Google Scholar 

  11. Garcia, B.A., Smalley, D.M., Cho, H., Shabanowitz, J., Ley, K., Hunt, D.F. J. Proteome Res. 4:1516–1521, 2005.

    PubMed  CAS  Google Scholar 

  12. Villar, M., Ortega-Perez, I., Were, F., Cano, E., Redondo, J.M., Vazquez, J. Proteomics 6:S16–S27, 2006.

    PubMed  Google Scholar 

  13. Garcia, B.A., Busby, S.A., Barber, C.M., Shabanowitz, J., Allis, C.D., Hunt, D.F. J. Proteome Res. 3:1219–1227, 2004.

    PubMed  CAS  Google Scholar 

  14. Martinez-Ruiz, A., Villanueva, L., Gonzalez de Orduna, C., Lopez-Ferrer, D., Higueras, M.A., Tarin, C., Rodriguez-Crespo, I., Vazquez, J., Lamas, S. Proc. Natl. Acad. Sci. U. S. A. 102:8525–8530, 2005.

    PubMed  CAS  Google Scholar 

  15. Zheng, L., Settle, M., Brubaker, G., Schmitt, D., Hazen, S.L., Smith, J.D., Kinter, M. J. Biol. Chem. 280:38–47, 2005.

    PubMed  CAS  Google Scholar 

  16. Syka, J.E., Coon, J.J., Schroeder, M.J., Shabanowitz, J., Hunt, D.F. Proc. Natl. Acad. Sci. U. S. A. 101:9528–9533, 2004.

    PubMed  CAS  Google Scholar 

  17. Le Blanc, J.C., Hager, J.W., Ilisiu, A.M., Hunter, C., Zhong, F., Chu, I. Proteomics 3:859–869, 2003.

    PubMed  CAS  Google Scholar 

  18. Amoresano, A., Monti, G., Cirulli, C., Marino, G. Rapid Commun. Mass Spectrom. 20:1400–1404, 2006.

    PubMed  CAS  Google Scholar 

  19. Sandra, K., Devreese, B., Van Beeaumen, J., Stals, I., Claeyssens, M. J. Am. Soc. Mass Spectrom. 15:413–423, 2004.

    PubMed  CAS  Google Scholar 

  20. Olsen, J.V., Mann, M. Proc. Natl. Acad. Sci. U. S. A. 101:13417–13422, 2004.

    PubMed  CAS  Google Scholar 

  21. Yates, J.R. III, Cociorva, D., Liao, L., Zabrouskov, V. Anal. Chem. 78:493–500, 2006.

    PubMed  CAS  Google Scholar 

  22. Hunt, D.F., Shabanowitz, J., Yates, J.R. III, Zhu, N.Z., Russell, D.H., Castro, M.E. Proc. Natl. Acad. Sci. U. S. A. 84:620–623, 1987.

    PubMed  CAS  Google Scholar 

  23. Hipple, J.A, Sommer, H., Thomas H.A. Phys. Rev. 76:1877–1878, 1949.

    Google Scholar 

  24. Anders, L.R., Beauchamp, J.L., Dunbar, R.C., Baldeschwieler, J.P. J. Chem. Phys. 45:1062–1065, 1966.

    CAS  Google Scholar 

  25. Comisarow, M.P., Marshall, A.G. Chem. Phys. Lett. 25:282–283, 1974.

    CAS  Google Scholar 

  26. Bogdanov, B., Smith, R.D. Mass Spectrom. Rev. 24:168–200, 2005.

    PubMed  CAS  Google Scholar 

  27. Haas, W., Faherty, B.K., Gerber, S.A., Elias. J.E., Beausoleil, S.A., Bakalarski, C.E., Li, X., Villen, J., Gygi, S.P. Mol. Cell. Proteomics 5:1326–1337, 2006.

    PubMed  CAS  Google Scholar 

  28. Strittmatter, E.F., Ferguson, P.L., Tang, K., Smith, R.D. J. Am. Soc Mass Spectrom. 14:980–991, 2003.

    PubMed  CAS  Google Scholar 

  29. Adkins, J.N., Monroe, M.E., Auberry, K.J., Shen, Y., Jacobs, J.M., Camp, D.G. II, Vitzthum, F., Rodland, K.D., Zangar, R.C., Smith, R.D., Pounds, J.G. Proteomics 5:3454–3466, 2005.

    PubMed  CAS  Google Scholar 

  30. Kingdon, K.H. Phys. Rev. 21:408–418, 1923.

    CAS  Google Scholar 

  31. Makarov, A. Anal. Chem. 72:1156–1162, 2000.

    PubMed  CAS  Google Scholar 

  32. Hu, Q., Noll, R.J., Makarov, A., Hardman, M., Cooks, R.G. J. Mass Spectrom. 40:430–443, 2005.

    PubMed  CAS  Google Scholar 

  33. Makarov, A., Denisov, E., Kholomeev, A., Balschun, W., Lange, O., Strupat, K., Horning, S. Anal. Chem. 78:2113–2120, 2006.

    PubMed  CAS  Google Scholar 

  34. Olsen, J.V., de Godoy, L.M., Li, G., Macek, B., Mortensen, P., Pesch, R., Makarov, A., Lange, O., Horning, S., Mann, M. Mol. Cell Proteomics 4:2010–2021, 2005.

    Google Scholar 

  35. Qin, J., Ruud, J., Chait, B.T. Anal. Chem. 68:1784–1791, 1996.

    PubMed  CAS  Google Scholar 

  36. Qin, J., Chait, B.T. Anal. Chem. 69:4002–4009, 1997.

    PubMed  CAS  Google Scholar 

  37. Carroll, J.A., Penn, S.G., Fannin, S.T., Wu, J., Cancilla, M.T., Green, M.K., Lebrilla, C.B. Anal. Chem. 68:1798–1804, 1996.

    PubMed  CAS  Google Scholar 

  38. Qin, J., Fenyo, D., Zhao, Y., Hall, W.W., Chao, D. M., Wilson, C.J., Young, R.A. Chait, B.T. Anal. Chem. 69:3995–4001, 1997.

    PubMed  CAS  Google Scholar 

  39. Wysocki, V.H., Tsaprailis, G., Smith, L.L., Breci, L.A. J. Mass Spectrom. 35:1399–1406, 2000.

    PubMed  CAS  Google Scholar 

  40. Tabb, D.L., Smith, L.L., Breci, L.A., Wysocki, V.H., Lin, D., Yates J.R., III. Anal. Chem. 75:1155–1163, 2003.

    PubMed  CAS  Google Scholar 

  41. Medzihradszky, K.F., Campbell, J.M., Baldwin, M.A., Falick, A.M., Juhasz, P., Vestal, M.L., Burlingame, A.L. Anal. Chem. 72:552–558, 2000.

    PubMed  CAS  Google Scholar 

  42. Yergey, A.L., Coorssen, J.R., Backlund, P.S. Jr., Blank, P.S., Humphrey, G.A., Zimmerberg, J., Campbell, J.M., Vestal, M.L. J. Am. Soc. Mass Spectrom. 13:784–791, 2002.

    PubMed  CAS  Google Scholar 

  43. Bienvenut, W.V., Deon, C., Pasquarello, C., Campbell, J.M., Sanchez, J.C., Vestal, M.L., Hochstrasser, D.F. Proteomics 2:868–876, 2002.

    PubMed  CAS  Google Scholar 

  44. Covey, T.R., Huang, E.C., Henion, J.D. Anal. Chem. 63:1193–1200, 1991.

    PubMed  CAS  Google Scholar 

  45. Zubarev, R.A., Kelleher, N.L., McLafferty, F.W. J. Am. Chem. Soc. 120: 3265–3266, 1998.

    CAS  Google Scholar 

  46. Zubarev, R.A., Kruger, N.A., Fridricksson, E.K., Lewis, M.A., Horn, D.M., Carpenter, B.K., McLafferty, F.W. J. Am. Chem. Soc. 121:2857–2862, 1999.

    CAS  Google Scholar 

  47. Cooper, H.J., Hakansson, K., Marshall, A.G. Mass Spectrom. Rev. 24:201–222, 2005.

    PubMed  CAS  Google Scholar 

  48. Coon, J.J., Ueberheide, B., Syka, J.E., Dryhurst, D.D., Ausio, J., Shabanowitz, J., Hunt, D.F. Proc. Natl. Acad. Sci. U .S. A. 102:9463–9468, 2005.

    PubMed  CAS  Google Scholar 

  49. Stensballe, A., Jensen, O.N., Olsen, J.V., Haselmann, K.F., Zubarev, R.A. Rapid Commun. Mass Spectrom. 14:1793–1800, 2000.

    PubMed  CAS  Google Scholar 

  50. Shi, S.D., Hemling, M.E., Carr, S.A., Horn, D.M., Lindh, I., McLafferty, F.W. Anal. Chem. 73:19–22, 2001.

    PubMed  CAS  Google Scholar 

  51. Renfrow, M.B., Cooper, H.J., Tomana, M., Kulhavy, R., Hiki, Y., Toma, K., Emmett, M.R., Mestecky, J., Marshall, A.G., Novak, J. J. Biol. Chem. 280:19136–19145, 2005.

    PubMed  CAS  Google Scholar 

  52. Hakansson, K., Cooper, H.J., Emmett, M.R., Costello, CE., Marshall, A.G., Nilsson C.L. Anal. Chem. 73:4530–4536, 2001.

    PubMed  CAS  Google Scholar 

  53. Kelleher, N.L., Zubarev, R.A., Bush, K., Furie, B., Furie, B.C., McLafferty, F.W., Walsh, C.T. Anal. Chem. 71:4250–4253, 1999.

    PubMed  CAS  Google Scholar 

  54. Cournoyer, J.J., Lin. C., O’Connor, P.B. Anal. Chem. 78:1264–1271, 2006.

    PubMed  CAS  Google Scholar 

  55. Cooper, H.J., Tatham, M.H., Jaffray, E., Heath, J.K., Lam, T.T., Marshall, A.G., Hay, R.T. Anal. Chem. 77:6310–6319, 2005.

    PubMed  CAS  Google Scholar 

  56. Syrstad, E.A., Turecek, F. J. Am. Soc Mass Spectrom. 16:208–224, 2005.

    CAS  Google Scholar 

  57. Breuker, K., Oh, H., Lin, C., Carpenter, B.K., McLafferty, F.W. Proc. Natl. Acad. Sci. U. S. A. 101:14011–14016, 2004.

    PubMed  CAS  Google Scholar 

  58. McFarland, M.A., Chalmers, M.J., Quinn, J.P., Hendrickson, C.L., Marshall, A.G. J. Am. Soc. Mass Spectrom. 16:1060–1066, 2005.

    PubMed  CAS  Google Scholar 

  59. Horn, D.M., Ge,Y., McLafferty, F.W. Anal. Chem. 72:4778–4784, 2000.

    PubMed  CAS  Google Scholar 

  60. Patrie, S.M., Charlebois, J.P., Whipple, D., Kelleher, N.L., Hendrickson, C.L., Quinn, J.P., Marshall, A.G., Mukhopadhyay, B. J. Am. Soc. Mass Spectrom. 15:1099–1108, 2004.

    PubMed  CAS  Google Scholar 

  61. Jebanathirajah, J.A., Pittman, J.L., Thomson, B.A., Budnik, B.A., Kaur, P., Rape, M., Kirschner, M., Costello, C.E., O’Connor, P.B. J. Am. Soc. Mass Spectrom. 16:1985–1999, 2005.

    PubMed  CAS  Google Scholar 

  62. Baba, T., Hashimoto, Y., Hasegawa, H., Hirabayashi, A., Waki, I. Anal. Chem. 76:4263–4266, 2004.

    PubMed  CAS  Google Scholar 

  63. Silivra, O.A., Kjeldsen, F., Ivonin, I.A., Zubarev. R.A. J. Am. Soc. Mass Spectrom. 16:22–27, 2005.

    PubMed  CAS  Google Scholar 

  64. Axelsson, J., Palmblad, M., Hakansson, K., Hakansson, P. Rapid Commun. Mass Spectrom. 13:474–477, 1999.

    PubMed  CAS  Google Scholar 

  65. Cooper, H.J., Akbarzadeh, S., Heath, J.K., Zeller, M. J. Proteome Res. 4:1538–1544, 2005.

    PubMed  CAS  Google Scholar 

  66. Rappsilber, J., Ryder, U., Lamond, A.I., Mann, M. Genome Res. 12:1231–1245, 2002.

    PubMed  CAS  Google Scholar 

  67. Schirle, M., Heurtier, M.A., Kuster, B. Mol. Cell. Proteomics 2:1297–1305, 2003.

    PubMed  CAS  Google Scholar 

  68. Schroeder, M.J., Webb, D.J., Shabanowitz, J., Horwitz, A.F., Hunt, D.F. J. Proteome Res. 4:1832–1841, 2005.

    PubMed  CAS  Google Scholar 

  69. Andersson, L., Porath, J. Anal. Biochem. 154:250–254, 1986.

    PubMed  CAS  Google Scholar 

  70. D’Ambrosio, C., Arena, S., Fulcoli, G., Scheinfeld, M.H., Zhou, D., D’Adamio, L., Scaloni, A. Mol. Cell. Proteomics 5:97–113, 2006.

    PubMed  CAS  Google Scholar 

  71. Ficarro, S.B., McCleland, M.L., Stukenberg, P.T., Burke, D.J., Ross, M.M., Shabanowitz, J., Hunt, D.F., White, F.M. Nat. Biotechnol. 20:301–305, 2002.

    PubMed  CAS  Google Scholar 

  72. Ficarro, S., Chertihin, O., Westbrook, V.A., White, F., Jayes, F., Kalab, P., Marto, J.A., Shabanowitz, J., Herr, J.C., Hunt, D.F., Visconti, P.E. J. Biol. Chem. 278:11579–11589, 2003.

    PubMed  CAS  Google Scholar 

  73. Salomon A.R., Ficarro, S.B., Brill, L.M., Brinker, A., Phung, Q.T., Ericson, C., Sauer, K., Brock, A., Horn, D.M., Schultz, P.G., Peters, E.C. Proc. Natl. Acad. Sci. U. S. A. 100:443–448, 2003.

    PubMed  CAS  Google Scholar 

  74. Brill, L.M., Salomon, A.R., Ficarro, S.B., Mukherji, M., Stettler-Gill, M., Peters, E.C. Anal. Chem. 76:2763–2772, 2004.

    PubMed  CAS  Google Scholar 

  75. Beausoleil, S.A., Jedrychowski, M., Schwartz, D., Elias, J.E., Villen, J., Li, J., Cohn, M.A., Cantley, L.C., Gygi, S.P. Proc. Natl. Acad. Sci. U. S. A. 101:12130–12135, 2004.

    PubMed  CAS  Google Scholar 

  76. Ballif, B.A., Villen, J., Beausoleil, S.A., Schwartz, D., Gygi, S.P. Mol. Cell Proteomics 3:1093–1101, 2004.

    PubMed  CAS  Google Scholar 

  77. Schwartz, D., Gygi, S.P. Nat. Biotechnol. 23:1391–1398, 2005.

    PubMed  CAS  Google Scholar 

  78. Oda, Y., Huang, K., Cross, F.R., Cowburn, D., Chait, B.T. Proc. Natl. Acad. Sci. U. S. A. 96:6591–6596, 1999.

    PubMed  CAS  Google Scholar 

  79. Washburn, M.P., Koller, A., Oshiro, G., Ulaszek, R.R., Plouffe, D., Deciu, C., Winzeler, E., Yates, J.R., III. Proc. Natl. Acad. Sci. U. S. A. 100:3107–3112, 2003.

    PubMed  CAS  Google Scholar 

  80. Wu, C.C., MacCoss, M.J., Howell, K.E., Matthews, D.E., Yates J.R., III. Anal. Chem. 76:4951–4959, 2004.

    PubMed  CAS  Google Scholar 

  81. Ong, S.E., Blagoev, B., Kratchmarova, I., Kristensen, D.B., Steen, H., Pandey, A., Mann, M. Mol. Cell Proteomics 1:376–386, 2002.

    PubMed  CAS  Google Scholar 

  82. Kratchmarova, I., Blagoev, B., Haack-Sorensen, M., Kassem, M., Mann M. Science 308:1472–1477, 2005.

    PubMed  CAS  Google Scholar 

  83. Ong, S.E., Kratchmarova, I., Mann, M. J. Proteome Res. 2:173–181, 2003.

    PubMed  CAS  Google Scholar 

  84. Gygi, S.P., Rist, B., Gerber, S.A., Turecek, F., Gelb, M.H., Aebersold, R. Nat. Biotechnol. 17:994–999, 1999.

    PubMed  CAS  Google Scholar 

  85. Li, J., Steen, H., Gygi, S.P. Mol. Cell Proteomics 2:1198–1204, 2003.

    PubMed  CAS  Google Scholar 

  86. Olsen, J.V., Andersen, J.R., Nielsen, P.A., Nielsen, M.L., Figeys, D., Mann, M., Wisniewski, J.R. Mol. Cell Proteomics 3:82–92, 2004.

    PubMed  CAS  Google Scholar 

  87. Zhang, X., Jin, Q.K., Carr, S.A., Annan, R.S. Rapid Commun. Mass Spectrom. 16:2325–2332, 2002.

    PubMed  CAS  Google Scholar 

  88. Yao, X., Freas, A., Ramirez, J., Demirev, P.A., Fenselau, C. Anal. Chem. 73:2836–2842, 2001.

    PubMed  CAS  Google Scholar 

  89. Ross, P.L., Huang, Y.N., Marchese, J.N., Williamson, B., Parker, K., Hattan, S., Khainovski, N., Pillai, S., Dey, S., Daniels, S., Purkayastha, S., Juhasz, P., Martin, S., Bartlet-Jones, M., He, F., Jacobson, A., Pappin, D.J. Mol. Cell Proteomics 3:1154–1169, 2004.

    PubMed  CAS  Google Scholar 

  90. Bondarenko, P.V., Cheliu, D., Shaler, T.A. Anal. Chem. 74:4741–4749, 2002.

    PubMed  CAS  Google Scholar 

  91. Wang, W., Zhou, H., Lin, H., Roy, S., Shaler, T.A., Hill, L.R., Norton, S., Kumar, P., Anderle, M., Becker, C.H. Anal. Chem. 75:4818–4826, 2003.

    PubMed  CAS  Google Scholar 

  92. Ono, M., Shitashige, M., Honda, K., Isobe, T., Kuwabara, H., Matsuzuki, H., Hirohashi, S., Yamada, T. Mol. Cell Proteomics 5:1338–1347, 2006.

    PubMed  CAS  Google Scholar 

  93. Wang, G, Wu, W.W., Zeng, W., Chou, C.L., Shen, R.F. J. Proteome Res. 5:1214–1223, 2006.

    PubMed  CAS  Google Scholar 

  94. Beck, H.C., Nielsen, E.C., Matthiesen, R., Jensen, H.L., Sehested, M., Finn, P., Grauslund, M., Hansen, A.M., Jensen, O.N. Mol. Cell Proteomics 5:1314–1325, 2006.

    PubMed  CAS  Google Scholar 

  95. Liu, H., Sadygov, R.G., Yates, J.R., III. Anal. Chem. 76:4193–4201, 2004.

    PubMed  CAS  Google Scholar 

  96. Old, W.M., Meyer-Arendt, K., Aveline-Wolf, L., Pierce, K.G., Mendoza, A., Sevinsky, J.R., Resing, K.A., Ahn, N.G. Mol. Cell Proteomics 4:1487–1502, 2005.

    PubMed  CAS  Google Scholar 

  97. Ruse, C.I., Willard, B.B., Jin, J.P., Haas, T., Kinter, M., Bond, M. Anal. Chem. 74:1658–1664, 2002.

    PubMed  CAS  Google Scholar 

  98. Willard, B.B., Ruse, C.I., Keightley, J.A., Bond, M., Kinter, M. Anal. Chem. 75:2370–2376, 2003.

    PubMed  CAS  Google Scholar 

  99. Steen H., Jebanathirajah J.A., Springer M., Kirschner M.W. Proc. Natl. Acad. Sci. U. S. A. 102:3948–3953, 2005.

    PubMed  CAS  Google Scholar 

  100. Ge, Y., Lawhorn, B.G., ElNaggar, M., Strauss, E., Park, J.H., Begley, T.P., McLafferty, F.W. J. Am. Chem. Soc. 124:672–678, 2002.

    PubMed  CAS  Google Scholar 

  101. Medzihradszky, K.F., Zhang, X., Chalkley, R.J., Guan, S., McFarland, M.A., Chalmers, M.J., Marshall, A.G., Diaz, R.L., Allis, C.D., Burlingame, A.L. Mol. Cell Proteomics 3:872–886, 2004.

    PubMed  CAS  Google Scholar 

  102. Siuti, N., Roth, M.J., Mizzen, C.A., Kelleher, N.L., Pesavento, J.J. J. Proteome Res. 5:233–239, 2006.

    PubMed  CAS  Google Scholar 

  103. Thomas, C.E., Kelleher, N.L., Mizzen, C.A. J. Proteome Res. 5:240–247, 2006.

    PubMed  CAS  Google Scholar 

  104. Roth, M.J., Forbes, A.J., Boyne, M.T, II., Kim, Y.B., Robinson, D.E., Kelleher, N.L. Mol. Cell Proteomics 4:1002–1008, 2005.

    PubMed  CAS  Google Scholar 

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  1. Belinda Willard
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  2. Suma Kaveti
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  3. Michael T. Kinter
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Editors and Affiliations

  1. Department of Pharmaceutical Sciences, Washington State University, Pullman, WA

    Sayed S. Daoud

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Willard, B., Kaveti, S., Kinter, M.T. (2008). Current and Emerging Mass Spectrometry Instrumentation and Methods for Proteomic Analyses. In: Daoud, S.S. (eds) Cancer Proteomics. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-169-7_1

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