Skip to main content

The Impact of Myasthenia Gravis on Mood, Cognitive Function, and Quality of Life

  • Chapter
  • First Online:
Myasthenia Gravis and Related Disorders

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

REFERENCES

  1. Phillips LH. The epidemiology of myasthenia gravis. Ann NY Acad Sci 2003;998, 407–412.

    Article  PubMed  Google Scholar 

  2. Sherwood L. Human Physiology: From Cells to Systems. Second Edition. West Publishing Company: New York, 1993.

    Google Scholar 

  3. Blalock JE, Smith EM. A complete regulatory loop between the immune and neuroendocrine systems. Fed Proc 1985;44:108–111.

    PubMed  CAS  Google Scholar 

  4. Maes M, Bosmans E, Meltzer HY. Immunoendocrine aspects of major depression. Relationships between plasma interleukin-6 and soluble interleukin-2 receptor, prolactin and cortisol. Eur Arch Psychiatry Clin Neurosci 1995;245:172–178.

    Article  PubMed  CAS  Google Scholar 

  5. Psychosocial factors predict CD and viral load change in men and women with human immunodeficiency virus in the era of highly active antiretroviral treatment. Ironson G, O’Cleirigh C, Fletcher MA, Laurenceau JP, Balbin E, Klimas N, Schneiderman N, Solomon G. Psychosom Med 2005;1013–1021.

    Google Scholar 

  6. Meyer E. Psychological disturbances in myasthenia gravis: A predictive study. Ann NY Acad Sci 1966;135:417–423.

    Article  PubMed  CAS  Google Scholar 

  7. Martin RD, Flegenheimer WV. Psychiatric aspects of the management of the myasthenic patient. Mt Sinai J Med 1971;38:594–601.

    PubMed  CAS  Google Scholar 

  8. Shinkai K, Ohmori O, Ueda N, Nakamura J, Amano T, Tsuji S. A case of myasthenia gravis preceded by major depression. JNeuropsychiatry Clin Neurosci 2001;13:116–117.

    Article  CAS  Google Scholar 

  9. Chafetz ME. Psychological disturbances in myasthenia gravis. Ann NY Acad Sci 1966;135:424–427.

    Article  PubMed  CAS  Google Scholar 

  10. MacKenzie KR, Martin MH, Howard FM. Myasthenia gravis: psychiatric concomitants. Canad Med Assn J 1969;100:988–991.

    CAS  Google Scholar 

  11. Graham JR. MMPI-2. Assessing Personality and Psychopathology. Second Edition. Oxford University Press: New York, 1993.

    Google Scholar 

  12. Schwartz ML, Cahill R. Psychopathology associated with myasthenia gravis and its treatment by psychotherapeutically oriented group counseling. JChron Dis 1971;24:543–552.

    Article  CAS  Google Scholar 

  13. Santy PA. Underdiagnosed myasthenia gravis in emergency psychiatric referrals. Ann Emerg Med 1983;12:397–398.

    Article  PubMed  CAS  Google Scholar 

  14. Magni G, Micaglio G, Ceccato MB, Lalli R, Bejato L, Angelini C. The role of life events in the myasthenia gravis outcome: a one-year longitudinal study. Acta Neurol Scand 1989;79:288–291.

    Article  PubMed  CAS  Google Scholar 

  15. Kleinman A. The Illness Narratives. Basic Books: New York, NY, 1988.

    Google Scholar 

  16. Paul RH, Cohen RA, Gilchrist J, Goldstein J. Fatigue and its impact on patients with myasthenia gravis. Muscle Nerve 2000;23:1402–1406.

    Article  PubMed  CAS  Google Scholar 

  17. Sneddon J. Myasthenia gravis: a study of social, medical, and emotional problems in 26 patients. Lancet 1980;1:526–528.

    Google Scholar 

  18. Paradis CM, Friedman S, Lazar RM, Kula RW. Anxiety disorders in a neuromuscular clinic. Am J Psychiatry 1993;150:1102–1104.

    PubMed  CAS  Google Scholar 

  19. Magni G, Micaglio GF, Lalli R, Bejato L, Candeago MR, Merskey H, Angelini C. Psychiatric disturbances associated with myasthenia gravis. Acta Psychiatr Scand 1988;77:443–445.

    Article  PubMed  CAS  Google Scholar 

  20. Paul RH, Cohen RA, Goldstein J, Gilchrist J. Severity of mood, self-evaluative and vegetative symptoms in myasthenia gravis. JNeuropsych Clin Neurosci 2000;12:499–501.

    Article  CAS  Google Scholar 

  21. Paul RH, Nash JM, Cohen RA, Gilchrist JM, Goldstein JM. Quality of life and well-being of patients with myasthenia gravis. Muscle Nerve 2001;24:512–516.

    Article  PubMed  CAS  Google Scholar 

  22. Nyenhuis DL, Rao SM, Zajecka JM, Luchetta T, Bernardin L, Garron DC. Mood disturbance versus other symptoms of depression in multiple sclerosis. JINS 1995;1:291–296.

    PubMed  CAS  Google Scholar 

  23. Brown ES, Suppes T. Mood symptoms during corticosteroid therapy: a review. Harv Rev Psychiatry 1998;5:239–246.

    Article  PubMed  CAS  Google Scholar 

  24. Padua L, Evoli A, Aprile I, Caliandro P, Mazza S, Padua R, Tonali P. Health-related quality of life in patients with myasthenia gravis and the relationship between patient-oriented assessment and conventional measurements. Neurol Sci 2001;22:363–369.

    Article  PubMed  CAS  Google Scholar 

  25. Rostedt A, Padua L, Stalberg EV. Correlation between regional myasthenic weakness and mental aspects of quality of life. Europ J Neurol 2006;13:191–193.

    Article  CAS  Google Scholar 

  26. Paul RH, Cohen RA, Zawacki T, Gilchrist JM, Aloia MS. What have we learned about cognition in myasthenia gravis? A review of methods and results. Neurosci Bio Behavior Rev 2001;25:75–81.

    Article  CAS  Google Scholar 

  27. Whiting J, Cooper J, Lindstrom JM. Antibodies in sera from patients with myasthenia gravis do not bind to nicotinic acetylcholine receptors from human brain. JNeuroimmunol 1987;16:205–213.

    Article  CAS  Google Scholar 

  28. Keesey JC. Does myasthenia affect the brain? J Neurol Sci 1999;170: 77–89.

    Article  PubMed  CAS  Google Scholar 

  29. Ochs C, Bradley J, Katholi C et al. Symptoms of patients with myasthenia gravis receiving treatment. J Medicine 1988;29:1–12.

    Google Scholar 

  30. Paul RH, Cohen RA, Gilchrist J, Aloia MS, Goldstein JM. Cognitive dysfunction in individuals with myasthenia gravis. JNeurol Sci 2000;179:59–64.

    Article  CAS  Google Scholar 

  31. Grohar-Murray ME, Becker A, Reilly S, Ricci M. Self-care actions to manage fatigue among myasthenia gravis patients. JNeurosci Nurs 1998;30:191–199.

    Article  CAS  Google Scholar 

  32. Steptoe A, Bolton J. The short-term influence of high and low intensity physical exercise on mood. Psychol Health 1988; 2:91–106.

    Article  Google Scholar 

  33. Fiske AD, Schneider W. Controlled and automatic processing during tasks requiring sustained attention: a new approach to vigilance. Human Factors 1981;23:737–750.

    Google Scholar 

  34. Paul RH, Cohen RA, Gilchrist J. Ratings of subjective mental fatigue relates to cognitive performance in patients with myasthenia gravis. JClin Neurosci 2002;9:243–246..

    Article  Google Scholar 

  35. Paul R, Beatty WW, Schneider R, Blanco CR, Hames KA. Cognitive and physical fatigue in multiple sclerosis: relations between self-report and objective performance. Applied Neuropsychology 1998;5:143–148.

    Article  PubMed  CAS  Google Scholar 

  36. Krupp LB, Elkins LE. Fatigue and declines in cognitive functioning in multiple sclerosis. Neurology 2000;10:934–939.

    Google Scholar 

  37. House JS, Landis KR, Umberson D. Social relationships and health. Science 1988;241:540–544.

    Article  PubMed  CAS  Google Scholar 

  38. Nicholson GA, Wilby J, Tennant C. Myasthenia gravis: the problem of a “psychiatric” misdiagnosis. Med J Australia 1986;144:632–638.

    PubMed  CAS  Google Scholar 

  39. Mishel MH. Reconceptualization of the uncertainty in illness theory. JNurs Sch, 1990;22:256–262.

    Article  CAS  Google Scholar 

  40. Mishel MH. Perceived uncertainty and stress in illness. Res Nurs Health 1984;7:163–171.

    Article  PubMed  CAS  Google Scholar 

  41. Mishel MH, Braden CJ. Uncertainty: a mediator between support and adjustment. West J Nurs Res 1987;9:43–57.

    Article  PubMed  CAS  Google Scholar 

  42. Bennett SJ. Relationships among selected antecedent variables and coping effectiveness in postmyocardial infarction patients. Res Nurs Health 1993;16:131–139.

    Article  PubMed  CAS  Google Scholar 

  43. Mullins LL, Cote MP, Fuemmeler BF, Jean VM, Beatty WW, Paul RH. Illness intrusiveness, uncertainty, and distress in individuals with multiple sclerosis. Rehabil Psychol 2001;46:139–153.

    Article  Google Scholar 

  44. Mishel MH, Sorenson DS. Uncertainty in gynecological cancer: a test of the mediating functions of mastery and coping. Nurs Res 1991;40:167–171.

    PubMed  CAS  Google Scholar 

  45. Mast ME. Adult uncertainty in illness: a critical review of research. Sch Inq Nurs Pract: Int J 1995;9:3–23.

    CAS  Google Scholar 

  46. Braden CJ, Mishel MH, Longman AJ, Burns LR. Self-help intervention project: women receiving treatment for breast cancer. Cancer Pract 1998;6:87–98.

    Article  PubMed  CAS  Google Scholar 

  47. Badger TA, Braden C, Mishel MH. Depression burden, self-help interventions, and side effect experience in women receiving treatment for breast cancer. Oncol Forum 2001;28:567–574.

    CAS  Google Scholar 

  48. Mishel M, Belyea M, Germino BB, Stewart JL, Bailey DE, Robertson, Mohler JLC. Helping patients with localized prostate cancer manage uncertainty and treatment side effects: nurse delivered psycho-educational intervention via telephone. Cancer 2002;94(6): 1854–1866.

    Article  PubMed  Google Scholar 

  49. Mishel MH, Germino BB, Belyea M, Stewart JL, Bailey DE, Mohler J, Robertson C. Moderators of outcomes from an uncertainty management intervention for men with localized prostate cancer. Nurs Res 2003;52(2): 89–97.

    Article  PubMed  Google Scholar 

  50. Mishel MH, Germino BB, Gil KM, Belyea M, LaNey IC, Stewart J, Porter L, Clayton M. Benefits from an uncertainty management intervention for African-American and Caucasian older long-term breast cancer survivors. Psychooncology 2005;14:962–978.

    Article  PubMed  Google Scholar 

  51. Devins GM, Binik YM, Hutchinson TA, Hollomby DJ, Barre PE, Guttmann RD. The emotional impact of end-stage renal disease: importance of patients’ perceptions of intrusiveness and control. Int J Psychiatry Med 1983–1984;13:327–343.

    Article  CAS  Google Scholar 

  52. Devins GM. Illness intrusiveness and the psychosocial impact of lifestyle disruptions in chronic life-threatening disease. Adv Ren Replace Ther 1994;1:251–263.

    PubMed  CAS  Google Scholar 

  53. Devins GM, Seland TP, Klein GM, Edworthy SM, Saary MJ. Stability and determinants of psychosocial well-being in multiple sclerosis. Rehabil Psycho 1993;38:11–26.

    Article  Google Scholar 

  54. Devins GM. Illness intrusiveness and the psychosocial impact of end-stage renal disease. In MA Hadry, J Kiernan, AH Kutscher, L Cahill, AI Bevenitsky eds. Psychosocial Aspects of End-Stage Renal Disease: Issues of Our Times. Haworth Press: New York, 1991, 83–102

    Google Scholar 

  55. Devins GM, Shnek ZM. Multiple sclerosis. In: RG Frank, TR Elliott eds. Handbook of Rehabilitation Psychology.American Psychological Association: Washington DC, 2000, 163–184.

    Chapter  Google Scholar 

  56. Devins GM, Beanlands H, Mandin H, Paul LC. Psychological impact of illness intrusiveness moderated by self-concept and age in end-stage renal disease. Health Psycho 1997;16:529–538.

    Article  CAS  Google Scholar 

  57. Devins GM, Stam HJ, Koopmans JP. Psychosocial impact of laryngectomy mediated by perceived stigma and illness intrusiveness. Can J Psychiatry 1994;39:608–616.

    PubMed  CAS  Google Scholar 

  58. Hough ES, Brumitt GA, Templin TN. Social support, demands of illness, and depression in chronically ill urban women. Health Care Women Int 2000;20:349–362.

    Google Scholar 

  59. Cott CA, Gignac MAM, Badley EM. Determinants of self-rated health for Canadians with chronic disease and disability. JEpidemiol Community Health 1999;53:731–736.

    Article  CAS  Google Scholar 

  60. Brown GW, Andrews B, Harris T, Adler Z, Bridge L. Social support, self esteem and depression. Psychol Med 1986;6:238–247.

    Google Scholar 

  61. Holahan CK, Holahan CJ. Self-efficacy, social support, and depression in aging: a longitudinal analysis. JGerontol: Psychol Sci 1987;42:65–68.

    CAS  Google Scholar 

  62. Schreurs KMG, de Ridder DT. Integration of coping and social support perspectives: implications for the study of adaptation to chronic diseases. Clin Psychol Rev 1997;17:89–112.

    Article  PubMed  CAS  Google Scholar 

  63. Smith CA, Dobbins CJ, Wallston KA. The mediational role of perceived competence in psychological adjustment to rheumatoid arthritis. JAppl Soc Psychol 1991;21:1218–1247.

    Article  Google Scholar 

  64. Blixen CE, Kippes C. Depression, social support, and quality of life in older adults with osteoarthritis. Image J Nurs Sch 1999;31:221–226.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Paul, R.H., Mullins, L.L., Gilchrist, J.M. (2009). The Impact of Myasthenia Gravis on Mood, Cognitive Function, and Quality of Life. In: Myasthenia Gravis and Related Disorders. Current Clinical Neurology. Humana Press. https://doi.org/10.1007/978-1-59745-156-7_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-59745-156-7_17

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-852-2

  • Online ISBN: 978-1-59745-156-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics