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REFERENCES
Newsom-Davis J, Mills KR. Immunological associations of acquired neuromyotonia (Isaacs' syndrome). Report of five cases and literature review. Brain 1993;116:453–469.
Denny-Brown D, Foley DM. Myokymia and the benign fasciculation of muscular cramps. Trans Assoc Am Physicians 1948;61:88–96.
Gamstorp I, Wohlfart G. A syndrome characterized by myokymia, myotonia, muscular wasting and increased perspiration. Acta Psychiatr Scand 1959; 34:181–194.
Isaacs H. A syndrome of continuous muscle-fibre activity. J Neurol Neurosurg Psychiatry 1961;24: 319–325.
Mertens HG, Zschoke S. Neuromyotonie. Klin Wocehenscher 1965;43:917–925.
Lance JW, Burke D, Pollard J. Hyperexcitability of motor and sensory neurons in neuromyotonia. Ann Neurol 1979;5:523–532.
Morvan A, De la chorée fibrillaire. Gaz Hebdon de Med Chirurg 1890;27:173–200.
Serratrice G, Azulay JP. Que reste-t-il de la choreé fibrillaire de Morvan? Rev Neurol 1994;150:257–265.
Halbach M, Homberg V, Freund HJ. Neuromuscular, autonomic and central cholinergic hyperactivity associated with thymoma and acetylcholine receptor–binding antibody. J Neurol (Berlin) 1987;234:433–436.
Liguori R, Vincent A, Clover L, et al. Morvan’s syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels. Brain 2001;124:2417–2426.
Maddison P, Lawn N, Mills KR, Vincent A, Donaghy M. Acquired neuromyotonia in a patient with spinal epidural abscess. Muscle Nerve 1998;21:672–674.
Tahmouch AJ, Alonso RJ, Tahmouch GP, et al. Cramp-fasciculation syndrome: a treatable hyperexcitable peripheral nerve disorder. Neurology 1991;41:1021–1024.
Turner MR, Madkhana A, Ebers GC, Clover L, Vincent A, McGavin G, Sarrigiannis P, Kennett R, Warrell DA. Wasp sting induced autoimmune neuromyotonia J Neurol Neurosurg Psychiatry. 2006;77:704–705.
Hart IK, Maddison P, Vincent A, Mills K, Newsom-Davis J. Phenotypic variants of autoimmune peripheral nerve hyperexcitability. Brain 2002; 125:1887–1895.
Smith KKE, Claussen GY, Fesenmeier JT, Oh SJ. Myokymia-cramp syndrome: evidence of hyperexcitable peripheral nerve. Muscle Nerve 1994;17:1065–1067.
Wakayama Y, Ohbu S, Machida H. Myasthenia gravis, muscle twitch, hyperhidrosis, and limb pain associated with thymoma: proposal of a possible new myasthenic syndrome. Tohoku J Exp Med 1991;164:285–291.
Ho WKH, Wilson JD. Hypothermia, hyperhidrosis, myokymia and increased urinary excretion of catecholamines associated with a thymoma. Med J Aust 1993;158:787–788.
Gutmann L, Libell D, Gutmann L. When is myokymia neuromyotonia? Muscle Nerve 2001;24:151–153.
Maddison P, Mills KR, Newsom-Davis J. Clinical, electrophysiological characterization of the acquired neuromyotonia phenotype of autoimmune peripheral nerve hyperexcitability. Muscle Nerve 2006;33:801–808.
Isaacs H. Continuous muscle fibre activity in an Indian male with additional evidence of terminal motor fibre abnormality. J Neurol Neurosurg Psychiatry 1967;30:126–133.
Arimura K, Arimura Y, Ng A, et al. The origin of spontaneous discharges in acquired neuromyotonia. A macro EMG study. Muscle Nerve 2005;116:1835–1839.
Deymeer F, Oge AE, Serdaroglu P, et al. The use of botulinum toxin in localizing neuromyotonia to the terminal branches of the peripheral nerve. Muscle Nerve 1998;21:643–646.
García-Merino A, Cabella A, Mora JS, Liaño H. Continuous muscle fiber activity, peripheral neuropathy, and thymoma. Ann Neurol 1991;29:215–218.
Irani PF, Purohit AV, Wadia HH. The syndrome of continuous muscle fiber activity. Acta Neurol Scand 1977;55:273–288.
Partanen VSJ, Soininen H, Saksa M, Riekkinen P. Electromyographic and nerve conduction findings in a patient with neuromyotonia, normocalcemic tetany and small-cell lung cancer. Acta Neurol Scand 1980;61:216–226.
Hosokawa S, Shinoda H, Sakai T, Kato M, Kuroiwa Y. Electrophysiological study on limb myokymia in three women. J Neurol Neurosurg Psychiatry 1987;50:877–881.
Bostock H, Cikurel K, Burke D. Threshold tracking techniques in the study of human peripheral nerve. Muscle Nerve 1998;21:137–158.
Burke D. Excitability of motor axons in neuromyotonia. Muscle Nerve 1999;22:797–799.
Maddison P, Newsom-Davis J, Mills KR. Strength-duration properties of peripheral nerve in acquired neuromyotonia. Muscle Nerve 1999;22: 823–830.
Kiernan MC, Hart IK, Bostock H. Excitability of motor axons in patients with spontaneous motor unit activity. J Neurol Neurosurg Psychiatry 2001;70:56–64.
Harman JB, Richardson AT. Generalized myokymia in thyrotoxicosis: report of a case. Lancet 1954;2:473–474.
Reeback J, Benton S, Swash M, Schwartz MS. Penicillamine-induced neuromyotonia. Brit Med J 1979;279:1464–1465.
Vilchez JJ, Cabello A, Benedito J, Villarroya T. Hyperkalaemic paralysis, neuropathy and persistent motor unit discharges at rest in Addison's disease. J Neurol Neurosurg Psychiatry 1980;43:818–822.
Benito-Leon J, Martin E, Vincent A, Fernandez-Lorente J, de Blas G. Neuromyotonia in association with essential thrombocythemia. J Neurol Sci 2000:173:78–79.
Gutmann L, Gutmann L, Schochet SS. Neuromyotonia and type 1 myofiber predominance in amyloidosis. Muscle Nerve 1996;19:1338–1341.
Hadjivassiliou M, Chattopadhyay AK, Davies-Jones GA, et al. Neuromuscular disorder as a presenting feature of coeliac disease. J Neurol Neurosurg Psychiatry 1997;63:770–775.
Le Gars L, Clerc D, Cariou D, et al. Systemic juvenile rheumatoid arthritis and associated Isaacs' syndrome. J Rheumatol 1997;24:178–180.
Benito-Leon J, Miguelez R, Vincent A, et al. Neuromyotonia in association with systemic sclerosis. J Neurol 1999;246:976–977.
Liguori R, Vincent A, Avoni P, et al. Acquired neuromyotonia after bone marrow transplantation. Neurology 2000;54:1390–1931
Vasilescu C, Alexianu M, Dan A. Muscle hypertrophy and a syndrome of continuous motor unit activity in prednisone-responsive Guillain–Barré polyneuropathy. J Neurol (Berlin) 1984;231:276–279.
Caress JB, Abend WK, Preston DC, Logigian EL. A case of Hodgkin's lymphoma producing neuromyotonia. Neurology, 1997;49:258–259.
Zifko U, Drlicek M, Machacek E, et al. Syndrome of continuous muscle fiber activity and plasmacytoma with IgM paraproteinemia. Neurology 1994;44:560–561.
Sinha S, Newsom-Davis J, Mills K, et al. Autoimmune aetiology for acquired neuromyotonia (Isaacs' syndrome). Lancet 1991;338: 75–77.
Shillito P, Molenaar PC, Vincent A, et al. Acquired neuromyotonia: Evidence for autoantibodies directed against K+ channels of peripheral nerves. Ann Neurol 1995;38:714–722.
Harvey AL, Rowan EG, Vatanpour H, Fatehi M, Castaneda O, Karlsson E. Potassium channel toxins and transmitter release. Ann NY Acad Sci 1994;710:1–10.
Ramaswami R, Gautam, M, Kamb A, et al. Human potassium channel genes: molecular cloning and functional expression. Mol Cell Neurosci 1990;1:214–223.
Kleopa KA, Elman LB, Lang B, Vincent A, Scherer SS. Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations. Brain. 2006 Jun;129 (Part 6):1570–1584. Epub 2006 Apr 13.
Hart IK, Waters C, Vincent A, et al. Autoantibodies detected to expressed K+ channels are implicated in neuromyotonia. Ann Neurol 1997;41:238–46
Rettig J, Heinemann SH, Wunder F, et al. Inactivation properties of voltage-gated potassium channels altered by presence of β-subunit. Nature 1994;369:289–294.
Leite MI, Jacob S, Viegas S, Cossins J, Clover L, Morgan BP, Beeson D, Willcox N, Vincent A. IgG1 antibodies to acetylcholine receptors in “seronegative” MG. Brain 2008;131:1940–1952.
Arimura K, Watanabe O, Kitajima I, et al. Antibodies to potassium channels of PC12 in serum of Isaacs' syndrome: western blot and immunohistochemical studies. Muscle Nerve 1997;20:299–305
Sonoda Y, Arimura K, Kurono A, et al. Serum of Isaacs' syndrome suppresses potassium channels in PC-12 cell lines. Muscle Nerve 1996;19:1439–1446.
Nagado T, Arimura K, Sonoda Y, et al. Potassium current suppression in patients with peripheral nerve hyperexcitability. Brain 1999;122:2057–2066.
Tomimitsu H, Arimura K, Nagado T, et al. Mechanism of action of voltage-gated K+ channel antibodies in acquired neuromyotonia. Annals Neurol 2004;56:440–444.
O'Hanlon GM, Plomp JJ, Chakrabarti M, et al. Anti-GQ1b ganglioside antibodies mediate complement-dependent destruction of the motor nerve terminal. Brain 2001;124:893–906
Verino S, Adamski J, Kryzer TJ, et al. Neuronal nicotinic ACh receptor antibody in subacute autonomic neuropathy and cancer-related syndromes. Neurology 1998;50:1806–1813.
Toyka KV, Zielasek J, Ricker K, et al. Hereditary neuromyotonia: a mouse model associated with deficiency or increased gene dosage of the PMP22 gene. J Neurol Neurosurg Psychiatry 1997;63:812–813.
Zielasek J, Martini R, Suter U, Toyka KV. Neuromyotonia in mice with hereditary myelinopathies. Muscle Nerve 2000;23:696–701.
Vincent A. Understanding neuromyotonia. Muscle Nerve 2000;23:655–657.
Verino S, Auger RG, Emslie-Smith AM, et al. Myasthenia, thymoma, presynaptic antibodies, and a continuum of neuromuscular hyperexcitability. Neurology 1999;53:1233–1239.
Hart IK, Leys K, Vincent A, et al. Autoantibodies to voltage-gated potassium channels in acquired neuromyotonia. Neuromusc Disord 1994;4:535(Abstr.).
Hart IK, Waters C, Newsom-Davis J. Cerebrospinal fluid and serum from acquired neuromyotonia patients seropositive for anti-potassium channel antibodies label dentate nucleus neurones. Ann Neurol 1996;40:554–555.
Josephs KA, Silber MH, Fealey RD, et al. Neurophysiologic studies in Morvan 2004;21:440–445.
Batocchi AP, Marca GD, Mirabella, M, et al. Relapsing-remitting autoimmune agrypnia. Ann Neurol 2001;50:668–671.
Buckley C, Oger J, Clover L, et al. Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann Neurol 2001;50:74–79
Vincent A, Buckley C, Schott JM, Baker I, Dewar BK, Detert N, Clover L, Parkinson A, Bien CG, Omer S, Lang B, Rossor MN, Palace J. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy- responsive form of limbic encephalitis. Brain. 2004 Mar;127(Part 3):701–12. Epub 2004 Feb 11.
Thieben MJ, Lennon VA, Boeve BF, Aksamit AJ, Keegan M, Vernino S. Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody. Neurology 2004 Apr 13;62(7):1177–1182.
Vincent A, Lang B, Kleopa KA.Autoimmune channelopathies and related neurological disorders. Neuron 2006 Oct 5;52(1):123–138.
Ishii A, Hayashi A, Ohkoshi N, et al. Clinical evaluation of plasma exchange and high dose intravenous immunoglobulin in a patient with Isaacs' syndrome. J Neurol Neurosurg Psychiatry 1994;57:840–842.
Van den Berg JS, van Engelen BG, Boerman RH, de Baets MH. Acquired neuromyotonia: superiority of plasma exchange over high-dose intravenous human immunoglobulin. J Neurol 1999;246:623–625.
Skeie GO, Apostolski S, Evoli A, Gilhus NE, Hart IK, Harms L, Hilton-Jones D, Melms A, Verschuuren J, Horge HW. Guidelines for the treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 2006 Jul;13(7):691–699.
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Vincent, A., Hart, I. (2009). Acquired Neuromyotonia. In: Myasthenia Gravis and Related Disorders. Current Clinical Neurology. Humana Press. https://doi.org/10.1007/978-1-59745-156-7_14
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