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Gene Expression Profiling in the Investigation of Diabetic Nephropathy

  • Chapter
The Diabetic Kidney

Part of the book series: Contemporary Diabetes ((CDI))

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Abstract

Diabetic nephropathy (DN) develops in about one-third of patients with diabetes, with genetic and environmental factors both contributing to the development of the disease. Clinical studies have established that hypertension, poor glycemic and lipid control, and smoking (1) increase the risk of the development of the disease. It is clear however, that environmental factors alone are not sufficient for the development of this complication (2). In contrast, the prevalence of diabetic retinopathy continues to rise with the duration of diabetes in most populations. Family studies among type 1 diabetics have shown that if one sibling develops nephropathy, the other sibling has a fourfold increased risk of developing it (3). These observations have clearly established the importance of genetic risk factors in the development of DN. It is likely that the genetic response to hyperglycemia varies among individuals and patients who develop a pattern of excessive regulation of nephropathy-related genes will be the ones at greatest risk of developing^DN.

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Author information

Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, Dorrace Hamilton Research Laboratories, New York, NY

    Katalin Susztak PhD, MD

  2. Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY

    Erwin Bottinger MD

  3. Center for Diabetic Kidney Disease, Dorrance Hamilton Research Laboratories and Division of Nephrology, Department of Medicine, Jefferson University, Philadelphia, PA

    Kumar Sharma MD

Authors
  1. Katalin Susztak PhD, MD
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  2. Erwin Bottinger MD
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  3. Kumar Sharma MD
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Editor information

Editors and Affiliations

  1. Division of Nephrology and Hypertension, Department of Medicine, Henry Ford Hospital, Detroit, MI

    Pedro Cortes MD

  2. Department of Internal Medicine M (Diabetes and Endocrinology), Aarhus University Hospital, Aarhus, Denmark

    Carl Erik Mogensen MD

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© 2006 Humana Press Inc., Totowa, NJ

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Susztak, K., Bottinger, E., Sharma, K. (2006). Gene Expression Profiling in the Investigation of Diabetic Nephropathy. In: Cortes, P., Mogensen, C.E. (eds) The Diabetic Kidney. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-59745-153-6_15

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  • DOI: https://doi.org/10.1007/978-1-59745-153-6_15

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-624-5

  • Online ISBN: 978-1-59745-153-6

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