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Implication of Polyamines in Apoptosis of Immunoresponse Cells

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Polyamine Cell Signaling

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Abstract

In many diseases, including host response to pathogens, dysregulation of the immune system is a hallmark. An important component of such events is alterations in apoptosis of immune cells. This may include failure of apoptosis, but most commonly involves loss of immune function from death of immune cells. We will review the role of polyamines in immune cell apoptosis and provide specific insights based on our laboratory’s work on the pathogenesis of Helicobacter pylori infection and the central role of polyamines in the associated apoptosis of macrophages.

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, TN

    Rupesh Chaturvedi

  2. Department of Medicine, Division of Gastroenterology, and Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN

    Keith T. Wilson

Authors
  1. Rupesh Chaturvedi
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  2. Keith T. Wilson
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Editor information

Editors and Affiliations

  1. Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD

    Jian-Ying Wang

  2. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD

    Robert A. Casero Jr.

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© 2006 Humana Press Inc., Totowa, NJ

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Chaturvedi, R., Wilson, K.T. (2006). Implication of Polyamines in Apoptosis of Immunoresponse Cells. In: Wang, JY., Casero, R.A. (eds) Polyamine Cell Signaling. Humana Press. https://doi.org/10.1007/978-1-59745-145-1_17

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