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Delta Receptors

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The Glutamate Receptors

Part of the book series: The Receptors ((REC))

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Summary

No endogenous ligands have been identified for the delta subfamily of ionotropic glutamate receptors (GluRδ1 and GluRδ2). Nevertheless, GluRδ2 plays indispensable roles in cerebellar functions; mice that lack the GluRδ2 gene display ataxia and impaired motor-related learning tasks. Recent studies of mutant mice, such as lurcher, hotfoot, and GluRδ2- knockout mice, have provided clues to the structure and function of GluRδ2. In particular, morphologic and electrophysiologic analyses of hotfoot and GluRδ2-knockout mice have demonstrated a unique role of GluRδ2 in synapse formation and its maintenance. In addition, an antibody specific for GluRδ2′s extracellular N-terminal indicated its direct role in controlling cerebellar long-term depression. These results suggest that GluRδ2 regulates distinct s pathways involved in synapse formation and synaptic plasticity.

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  1. Michisuke Yuzaki
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  1. Department of Anesthesiology and Biological Chemistry Department of Anatomy and Neurobiology, Washington University Pain Center Washington University School of Medicine, St. Louis, MO

    Robert W. Gereau PhD

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL

    Geoffrey T. Swanson PhD

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© 2008 Humana Press

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Yuzaki, M. (2008). Delta Receptors. In: Gereau, R.W., Swanson, G.T. (eds) The Glutamate Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-055-3_4

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