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Metabotropic Glutamate Receptor-Dependent Synaptic Plasticity

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The Glutamate Receptors

Part of the book series: The Receptors ((REC))

Summary

Long-term potentiation (LTP) and long-term depression (LTD) are important forms of synaptic plasticity thought to underlie many brain processes such as those involved in brain development, memory, and drug addiction. The metabotropic glutamate receptors (mGluRs) are capable of inducing both LTP and LTD, and also of modulating the induction of plasticity initiated by other receptor systems. Although early work focused on the role of mGluRs in LTP, the precise nature of their involvement in LTP induction remains unclear. However, there is considerable evidence that activation of mGluRs can induce LTD in numerous brain regions. This chapter reviews the evidence for mGluR involvement in LTP induction and discusses the roles of mGluRs in LTD. In particular it describes the signaling pathways and expression mechanisms of two prominent forms of LTD—those seen in the CA1 region of the hippocampus and the cerebellum.

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Authors
  1. Stephen M. Fitzjohn
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  2. Zafar I. Bashir
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Editors and Affiliations

  1. Department of Anesthesiology and Biological Chemistry Department of Anatomy and Neurobiology, Washington University Pain Center Washington University School of Medicine, St. Louis, MO

    Robert W. Gereau PhD

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL

    Geoffrey T. Swanson PhD

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© 2008 Humana Press

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Fitzjohn, S.M., Bashir, Z.I. (2008). Metabotropic Glutamate Receptor-Dependent Synaptic Plasticity. In: Gereau, R.W., Swanson, G.T. (eds) The Glutamate Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-055-3_13

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