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Chromosome-Engineered Mouse Models

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Genomic Disorders

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Abstract

Chromosome rearrangements cause genomic disorders and cancer in human. Region-specific low-copy repeats (LCRs) can mediate nonallelic homologous recombination (NAHR) that results in chromosome rearrangements. Using the Cre-loxP site-specific recombination system, chromosome rearrangements that cause genomic disorders and cancer can be recapitulated in the mouse. Technology advancements in mouse genetics, such as recombineering, will undoubtedly facilitate modeling genetic changes associated with genomic disorders in the mouse.

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Authors and Affiliations

  1. The Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK

    Pentao Liu PhD

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  1. Pentao Liu PhD
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Editors and Affiliations

  1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX

    James R. Lupski MD, PhD  & Pawel Stankiewicz MD, PhD  & 

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© 2006 Humana Press Inc., Totowa, NJ

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Liu, P. (2006). Chromosome-Engineered Mouse Models. In: Lupski, J.R., Stankiewicz, P. (eds) Genomic Disorders. Humana Press. https://doi.org/10.1007/978-1-59745-039-3_26

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  • DOI: https://doi.org/10.1007/978-1-59745-039-3_26

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