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The Multiple Roles of the Oncogenic Protein SKI in Human Malignant Melanoma

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From Melanocytes to Melanoma

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Abstract

Cellular localization, association with different protein partners, and posttranslational modifications can dramatically change protein function. SKI and the highly homologous protein snoN are potent repressors of transforming growth factor-β signaling through their association with the Smad proteins. In fact, SKI can act as molecular switch converting the Smad proteins from an activating to a repressing entity on chromatin. SKI also plays additional roles in melanomas: in association with the LIM protein FHL2 activates β-catenin signaling, a pathway associated with cancer progression. This chapter reviews the transcriptional co-repressor and co-activator activities of SKI and discusses their biological significance for melanoma tumor progression.

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Author information

Authors and Affiliations

  1. Department of Pathology, Huffington Center on Aging, Baylor College of Medicine, Houston, TX

    Dahu Chen & Qiushi Lin

  2. Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA

    I. Saira Mian

  3. Department of Pathology, Baylor College of Medicine, Houston, TX

    Jon Reed

  4. Huffington Center on Aging, Department of Molecular and Cellular Biology, and Department of Pathology, Baylor College of Medicine, Houston, TX

    Estela E. Medrano

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  1. Dahu Chen
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  2. Qiushi Lin
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  3. I. Saira Mian
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Editors and Affiliations

  1. Laboratory of Cell Biology National Cancer Institute, National Institutes of Health, Bethesda, MD

    Vincent J. Hearing PhD

  2. Department of Surgery, University of California, San Francisco

    Stanley P. L. Leong MD

  3. School of Medicine, San Francisco, CA

    Stanley P. L. Leong MD

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© 2006 Humana Press Inc., Totowa, N.J.

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Chen, D., Lin, Q., Mian, I.S., Reed, J., Medrano, E.E. (2006). The Multiple Roles of the Oncogenic Protein SKI in Human Malignant Melanoma. In: Hearing, V.J., Leong, S.P.L. (eds) From Melanocytes to Melanoma. Humana Press. https://doi.org/10.1007/978-1-59259-994-3_12

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  • DOI: https://doi.org/10.1007/978-1-59259-994-3_12

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-459-3

  • Online ISBN: 978-1-59259-994-3

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