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Intensity-Modulated Radiation Therapy in the Management of Head and Neck Cancer

  • Chapter
Squamous Cell Head and Neck Cancer

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Head and neck cancer represents a complex collection of tumors involving mucosal surfaces of the upper aerodigestive tract. Approximately 43,000 cases are diagnosed each year in the United States, representing 3 to 4% of all cancers (1). Worldwide, head and neck cancer represents a much broader oncology problem (∼500,000 annual cases), with tumor development strongly associated with chronic tobacco and alcohol use.

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References

  1. Greenlee RT, Hill-Harmon MB, Murray T, et al. Cancer statistics, 2001. CA Cancer J Clin 2001; 51:15–36.

    Article  PubMed  CAS  Google Scholar 

  2. Harari PM, Sharda NN, Brock LK, Paliwal BR. Improving dose homogeneity in routine head and neck radiotherapy with custom 3-D compensation. Radiother Oncol 1998; 49:67–71.

    Article  PubMed  CAS  Google Scholar 

  3. Intensity Modulated Radiation Therapy Collaborative Working Group. Intensity-modulated radiotherapy: current status and issues of interest. [Review] Int J Radiat Oncol Biol Phys 2001; 51:880–914.

    Article  Google Scholar 

  4. Low DA, Chao KSC, Mutic S, et al. Quality assurance of serial tomotherapy for head and neck patient treatments. Int J Radiat Oncol Biol Phys 1998; 42:681–692.

    Article  PubMed  CAS  Google Scholar 

  5. Tomé WA, Meeks SL, McNutt TR, et al. Optically guided intensity modulated radiotherapy. Radiother Oncol 2001; 61:33–44.

    Article  PubMed  Google Scholar 

  6. Chao KS, Wippold FJ, Ozyigit G, et al. Determination and delineation of nodal target volumes for head-and-neck cancer based on patterns of failure in patients receiving definitive and postoperative IMRT. Int J Radiat Oncol Biol Phys 2002; 53:1174–1184.

    Article  PubMed  Google Scholar 

  7. Gregoire V, Coche E, Cosnard G. Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy: Proposal for standardizing terminology and procedure based on surgical experience. Radiother Oncol 2000; 56:135–150.

    Article  PubMed  CAS  Google Scholar 

  8. Nowak PJ, Wijers OB, Lagerwaard FJ, et al. A three dimensional CT-based target definition for elective irradiation of the neck. Int J Radiat Oncol Biol Phys 1999; 45:33–39.

    Article  PubMed  CAS  Google Scholar 

  9. Wijers OB, Levendag PC, Tan T, et al. A simplified CT-based definition of the lymph node levels in the node negative neck. Radiother Oncol 1999; 52:25–42.

    Article  Google Scholar 

  10. Som PM, Curtin SD, Mancuso AA. An imaging-based classification of the cervical nodes designed as an adjunct to recent clinically based nodal classifications. Arch Otolaryngol Head Neck Surg 1999; 125:388–396.

    PubMed  CAS  Google Scholar 

  11. Levendag P, Braaksma M, Coche E, et al. Rotterdam and Brussels CT-based neck nodal delineation compared with the surgical levels as defined by the American Academy of Otolaryngology-Head and Neck Surgery. Int J Radiat Oncol Biol Phys 2004; 58:113–123.

    Article  PubMed  Google Scholar 

  12. Grégoire V, Levendag P, Ang KK, et al. CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC, RTOG consensus guidelines. Radiother Oncol 2003; 69:227–236.

    Article  PubMed  Google Scholar 

  13. Lee N, Xia P, Fischbein NJ, et al. Intensity-modulated radiation therapy for head-and-neck cancer: the UCSF experience focusing on target volume delineation. Int J Radiat Biol Phys 2003; 57:49–60.

    Article  Google Scholar 

  14. Prin-Braam PM, Raaijmakers CPJ, Terhaard CHJ. Location of cervical lymph node metastases in oropharyngeal and hypopharyngeal carcinoma: implications for cranial border of elective nodal target volumes. Int J Radiat Oncol Biol Phys 2004;58:132–138.

    Article  Google Scholar 

  15. Hong TS, Tomé WA, Chappell RJ, et al. Variations in target delineation for head and neck IMRT: An international multi-institutional study.[abstract] Presented at ASTRO 2004. Int J Radiat Oncol Biol Phys 2004;60:S157–S158.

    Article  Google Scholar 

  16. Mendenhall WM, Million RR, Cassisi NJ. Squamous cell carcinoma of the head and neck treated with radiation therapy: the role of neck dissection for clinically positive neck nodes. Int J Radiat Oncol Biol Phys 1986; 12:737–740.

    Google Scholar 

  17. Eisbruch A, Haken RKT, Kim HM, et al. Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys 1999; 45:577–587.

    Article  PubMed  CAS  Google Scholar 

  18. Hong TS, Tomé WA, Chappell RJ, et al. The impact of daily set-up variations on head and neck IMRT. Int J Radiat Oncol Biol Phys 2005;61:779–788.

    Article  PubMed  Google Scholar 

  19. Chao KS, Ozyigit G, Tran BN, et al. Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys 2002; 55:312–3212.

    Article  Google Scholar 

  20. Dawson, LA, Anzai Y, Marsh L, et al. Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys 2000; 46:1117–1126.

    Article  PubMed  CAS  Google Scholar 

  21. Butler EB, Teh BS, Grant WH, et al. SMART (simultaneous modulated accelerated radiation therapy) boost: a new accelerated fractionation schedule for the treatment of had and neck cancer with intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys 1999; 45:21–32.

    Article  PubMed  CAS  Google Scholar 

  22. Lee N, Xia P, Quivey JM, Sultanem K, et al. Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience. Int J Radiat Oncol Biol Phys 2002; 53:12–22.

    Article  PubMed  Google Scholar 

  23. Amosson CM, Teh BS, Van T, et al. SMART (simultaneous modulated accelerated radiation therapy) boost technique-correlation of subjective xerostmia and dosimetric parameters of the parotid glands. Int J Radiat Oncol Biol Phys 2002; 54(suppl):S18–S19.

    Article  Google Scholar 

  24. Lin A, Marsh L, Dawson LA, et al. Local-regional (LR) recurrences near the base of the skull following IMRT of head and neck (HN) cancer: implications for target delineation in the high neck and for parotid sparing. Int J Radiat Oncol Biol Phys 2003; 57(suppl):S155.

    Google Scholar 

  25. Song S, Tome WA, Mehta MP, et al. Emphasizing conformal avoidance versus target definition for IMRT planning in head and neck cancer. Int J Radiat Oncol Biol Phys 2003; 57(suppl):S299–S300.

    Google Scholar 

  26. Chao KSC, Ozygit G, Blanco AI, et al. Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume. Int J Radiat Oncol Biol Phys 2004; 59:43–50.

    Article  PubMed  Google Scholar 

  27. Eisbruch A, Marsh LH, Dawson LA, et al. Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing. Int J Radiat Oncol Biol Phys 2004; 59:28–42.

    Article  PubMed  Google Scholar 

  28. Eisbruch A, Kim HJ, Terrell JE, et al. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys 2001; 50:695–704.

    Article  PubMed  CAS  Google Scholar 

  29. Chao KSC, Deasy JO, Markman J, et al. A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results. Int J Radiat Oncol Biol Phys 2001; 49:907–916.

    Article  PubMed  CAS  Google Scholar 

  30. Astreinidou E, Dehnad H, Terhaard CHJ, et al. Level II lymph nodes and radiation-induced xerostomia. Int J Radiat Oncol Biol Phys 2004; 58:124–131.

    Article  PubMed  Google Scholar 

  31. Reddy SP, Leman CR, Marks JE, et al. Parotid-sparing irradiation for cancer of the oral cavity-maintenance of oral nutrition and body weight by preserving parotid function. Am J Clin Oncol 2001; 24:341–346.

    Article  PubMed  CAS  Google Scholar 

  32. Parliament MB, Scrimger RA, Anderson SG, et al. Preservation of oral health-related quality of life and salivary flow rates after inverse-planned intensity-modulated radiotherapy (IMRT) for head-and-neck cancer. Int J Radiat Oncol Biol Phys 2004; 58:663–673.

    Article  PubMed  Google Scholar 

  33. Halperin HC. Overpriced technology in radiation oncology. Int J Radiat Oncol Biol Phys 2000; 48:917–918.

    Article  PubMed  CAS  Google Scholar 

  34. Glatstein E. The return of the snake oil salesman. Int J Radiat Oncol Biol Phys 2003; 55:561–562.

    Article  PubMed  Google Scholar 

  35. Mell LK, Roeske JC, Mundt AJ. A survey of intensity-modulated radiation therapy in the United States. Cancer 2003; 98:204–211.

    Article  PubMed  Google Scholar 

  36. Fu KK, Pajak, TF, Trotti A, et al. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int J Radiat Oncol Biol Phys 2000; 48:7–16.

    Article  PubMed  CAS  Google Scholar 

  37. Fowler JF, Harari PM. Confirmation of improved local-regional control with altered fractionation in head and neck cancer. Int J Radiat Oncol Biol Phys 2000; 48:3–6.

    Article  PubMed  CAS  Google Scholar 

  38. Horiot JC, Le Fur R, N’Guyen T. Hyperfractionated versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiother Oncol. 1992; 25:231–241.

    Article  PubMed  CAS  Google Scholar 

  39. Hall EJ, Wu CS. Radiation-induced second cancers: the impact of 3D-CRT and IMRT. [Review] Int J Radiat Oncol Biol Phys 2003; 56:83–88.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Human Oncology, University of Wisconsin Medical School, Madison, WI

    Theodore S. Hong MD, Wolfgang A. Tomé PhD & Paul M. Harari MD

Authors
  1. Theodore S. Hong MD
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  2. Wolfgang A. Tomé PhD
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  3. Paul M. Harari MD
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Editor information

Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, OH

    David J. Adelstein MD

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© 2005 Humana Press Inc., Totowa, NJ

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Hong, T.S., Tomé, W.A., Harari, P.M. (2005). Intensity-Modulated Radiation Therapy in the Management of Head and Neck Cancer. In: Adelstein, D.J. (eds) Squamous Cell Head and Neck Cancer. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-59259-938-7_8

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  • DOI: https://doi.org/10.1007/978-1-59259-938-7_8

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-473-9

  • Online ISBN: 978-1-59259-938-7

  • eBook Packages: MedicineMedicine (R0)

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