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Targeted Therapies in Head and Neck Cancer

  • Chapter
Squamous Cell Head and Neck Cancer

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Squamous cell carcinoma of the head and neck (HNSCC) can be treated with various modalities including radiotherapy, chemotherapy, and surgery. These are often employed in combination, with each playing a substantial and complementary role. Using a multidisciplinary approach, investigators have recently been able to achieve improved survival outcomes for patients with locally advanced, nonmetastatic disease—including both increased long-term survival rates (now approaching 70% in recent reports) (1–]3) and organ preservation (4,5). Nevertheless, in approx 50% of high-risk patients tumors will recur (1–3,6), often with distant metastasis, making the cancer incurable and shifting the treatment goal toward palliation. In addition, short- and long-term toxicities of combination therapy are significant, with xerostomia, esophageal strictures, dysphagia, and increased aspiration risk commonly encountered.

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Authors and Affiliations

  1. Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL

    Tanguy Y. Seiwert MD & Ezra E. W. Cohen MD

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  1. Tanguy Y. Seiwert MD
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  1. Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, OH

    David J. Adelstein MD

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Seiwert, T.Y., Cohen, E.E.W. (2005). Targeted Therapies in Head and Neck Cancer. In: Adelstein, D.J. (eds) Squamous Cell Head and Neck Cancer. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-59259-938-7_17

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