Abstract
The normal cardiac cycle is initiated by electrical events that precede cardiac contraction. Abnormalities in the initiation and propagation of cardiac impulses may result in a variety of arrhythmias. The purpose of this chapter is to highlight the cellular mechanisms responsible for normal impulse formation and conduction, and to review the clinical consequences when these mechanisms are perturbed.
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Recommended Reading
Ackerman MJ, Clapham DE. Ion channels-basic science and clinical disease. N Engl J Med 1997;336:1575–1586.
Lerman BB, Stein KM, Markowitz SM, et al. Ventricular arrhythmias in normal hearts. Cardiol Clin 2000;18:265–291.
Glaaser IW, Kass RS, Clancy CE. Mechanisms of genetic arrhythmias: from DNA to ECG. Prog Cardiovasc Dis 2003;46:259–270.
Zipes DP, Jalife F, eds. Cardiac Electrophysiology: From Cell to Bedside, 3rd ed. W. B. Saunders, Philadelphia, 2000, chapters 40, 70, 72, and 94.
Jalife J, Delmar M, Davidenko J, et al. Basic Cardiac Electrophysiology for the Clinician. Futura Publishing, Armonk, NY, 1999.
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Iwai, S., Markowitz, S.M., Mittal, S., Stein, K.M., Lerman, B.B. (2005). Electrophysiology of Cardiac Arrhythmias. In: Rosendorff, C. (eds) Essential Cardiology. Humana Press. https://doi.org/10.1007/978-1-59259-918-9_16
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DOI: https://doi.org/10.1007/978-1-59259-918-9_16
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