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Diabetes and Immunity

  • Chapter
Nutrition and Immunology

Abstract

Diabetes mellitus is a metabolic disease characterized by alterations in insulin production, insulin action, or a combination of both, leading to abnormal hyperglycemia (1–3). Diabetes is a chronic disease that has no cure and is an increasing major public health problem (4). The chronic nature of diabetes frequently leads to debilitating complications resulting primarily from nonenzymatic glycation of nerves and blood vessels supplying organ systems (1–3). For example, diabetes is the main cause of blindness in the United States and accounts for approximately 25% of chronic renal failure (3). Diabetes has also been associated with premature death from cardiovascular diseases (4,5). Total social and medical costs in the United States for people with diabetes exceeds $92 billion per year (3). Over 90% of the cases of diabetes are thought to be genetically encoded and are classified as either type 1 (insulin-dependent diabetes mellitus) or type 2 (non-insulindependent diabetes mellitus) diabetes. Type 2 diabetes comprises the majority of cases and is typically late in onset, associated with obesity, and characterized by insulin resistance (1–3). Approximately 15.3 million North Americans have type 2 diabetes (3).

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Authors
  1. Manuel E. Baldeón
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  2. H. Rex Gaskins
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Editors and Affiliations

  1. Division of Rheumatology/Allergy and Clinical Immunology, Department of Internal Medicine, University of California at Davis, Davis, CA, USA

    M. Eric Gershwin MD

  2. Department of Food Science and Technology, University of California at Davis, Davis, CA, USA

    J. Bruce German PhD

  3. Department of Nutrition, University of California at Davis, Davis, CA, USA

    Carl L. Keen PhD

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© 2000 Springer Science+Business Media New York

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Baldeón, M.E., Gaskins, H.R. (2000). Diabetes and Immunity. In: Gershwin, M.E., German, J.B., Keen, C.L. (eds) Nutrition and Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-709-3_25

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  • DOI: https://doi.org/10.1007/978-1-59259-709-3_25

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-148-6

  • Online ISBN: 978-1-59259-709-3

  • eBook Packages: Springer Book Archive

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