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Growth Hormone and Growth Hormone Secretagogues in Adults

  • Chapter
Hormone Replacement Therapy

Part of the book series: Contemporary Endocrinology ((COE,volume 13))

Abstract

The association of growth hormone (GH) with the promotion of linear growth in childhood has focused attention away from its role in adults, but GH secretion continues throughout life, reaching a maximum in adolescence and then declining progressively with age. Many age-related changes resemble those of patients with classical GH deficiency (GHD), including a reduction in muscle and bone mass, an increase in body fat, diminished exercise capacity, and adverse changes in lipoprotein profiles (1). There are other changes less classically associated with GHD that may also be related to the age-related decline in GH secretion. Sleep disorders, for example, become more common with aging, and because nocturnal GH secretion is synchronized with slow-wave sleep, it has been suggested that GH, or the stimuli to GH secretion, may promote as well as respond to sleep.

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Authors
  1. David E. Cummings MD
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  2. George R. Merriam MD
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Editors and Affiliations

  1. Division of Endocrinology and Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA

    A. Wayne Meikle MD

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Cummings, D.E., Merriam, G.R. (1999). Growth Hormone and Growth Hormone Secretagogues in Adults. In: Meikle, A.W. (eds) Hormone Replacement Therapy. Contemporary Endocrinology, vol 13. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-700-0_4

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  • DOI: https://doi.org/10.1007/978-1-59259-700-0_4

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