Abstract
Androstenedione first appeared in early 1997 in body-building magazines, where it was advertised as a natural anabolic agent. It has become an attractive, legal alternative to anabolic steroids for professional and recreational athletes, particularly those engaged in “power” sports who wish to increase muscle mass and endurance (Anonymous, 1998; Anonymous, 1998, Uralets and Gillette, 1999).
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References
Androstenedione. Available from: URL: http://www.nutritionalsupplements.com. Accessed June 13, 2001.
Anonymous. Creatine and androstenedione—two “dietary supplements.” Med Lett Drugs Ther 1998; 40: 105–6.
Ballantyne CS, Phillips SM, MacDonald JR, Tarnopolsky MA, MacDougall JD. The acute effects of androstenedione supplementation in healthy young males. Can J Appl Physiol 2000; 25: 68–78.
Birchard K. Body-building supplement fails to strengthen and may harm health. Lancet 1999; 353: 1943.
Blum R. Decision on androstenedione months away. Associated Press. New York. October 30, 1998. Available from: URL: http://www.augustasports.com/stories/10098/oth_LS02349000.shtml. Accessed on January 24, 2001.
Boschi S, De Iasio R, Mesini P, et al. Measurement of steroid hormones in plasma by isocratic high performance liquid chromatography coupled to radioimmunoassay. Clin Chim Acta 1994; 231: 107–13.
Broeder CE, Quindry J, Brittingham K, et al. The andro project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000; 160: 3093–104.
Brown GA, Vukovich MD, Martini ER, et al. Endocrine responses to chronic androstenedione intake in 30- to 56-year-old men. J Clin Endocrinol Metab 2000a; 85: 4074–80.
Brown GA, Vukovich MD, Reifenrath TA, et al. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 2000b; 10: 340–59.
Catlin DH, Leder BZ, Aherns B, et al. Trace contamination of over-the-counter and positive urine test results for a nandrolone metabolite. JAMA 2000; 284: 2618–21.
DeCree C. Androstenedione and dehydroepiandrosterone for athletes. Lancet 1999; 354: 779–80.
Giussani DA, Winter JA, Jenkins SL, et al. Changes in fetal plasma corticotropin-releasing hormone during androstenedione-induced labor in the Rhesus monkey: lack of an effect on the fetal hypothalamo-pituitary-adrenal axis. Endocrinology 1998; 139: 2803–10.
Goldifien A. Adrenocroticosteroids and adrenocortical antagonists. In: Katzung BG (ed.) Basic and clinical pharmacology. 7th ed. Stamford, CT: Appleton and Lange; 1998a.
Goldifien A. The gonadal hormones and inhibitors. In Katzung BG (ed.) Basic and clinical pharmacology, 7th ed. Stamford, CT: Appleton and Lange; 1998b.
Hill M, Hampl R, Petrik R, Starka L. Concentration of the endogenous antiandrogen epitestosterone and androgenic C19-steroids in hyperplastic prostatic tissue. Prostate 1996; 28: 347–51.
Kachhi PN, Henderson SO. Priapism after androstenedione intake for athletic performance enhancement. Ann Emerg Med 2000; 35: 391–3.
King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men. JAMA 1999; 281: 2020–8.
Kochakian CD, Murlin JR. The relationship of synthetic male hormone androstenedione to the protein and energy metabolism of castrated dogs and the protein metabolism of a normal dog. Am J Physiol 1936; 117: 642–57.
Labrie F, Belanger A, Luu-The V, et al. DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: its role in aging. Steroids 1998; 63: 322–8.
Leder BZ, Longcope C, Catlin DH, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000; 283: 779–82.
Longcope C. Androgen metabolism and the menopause. Semin Reprod Endocrinol 1998; 16: 111–15.
Longcope C. Dehydroepiandrostereone metabolism. J Endocrinol 1996; 150 (suppl): S 125–7.
Mahesh VB, Greenblatt RB. The in vivo conversion of dehydroepiandrosterone and androstenedione to testosterone in the human. Acta Endocrinol 1962; 41: 400–6.
NBA (National Basketball Association) News. NBA committee adds andro as banned substance, upsets union, New York, March 20, 2000. Available from: URL: www.webcraawlersports.excite.com/nba/news/ando. Accessed Jan 24, 2001.
NCAA. 2002–2003 NCAA Banned Drug Classes. Available from: URL:http://www.ncaa.org. Accessed Sept 3, 2002.
Office of the Attorney General, State of California. Attorney General Lockyer seeks consumer warnings on popular bodybuilding “andro” supplements as required by California’s Proposition 65. Available from: http://www.caag.state.ca.us/newsalerts/2001/01–081.htm. Accessed December 21, 2001.
Rasmussen BB, Volpe E, Gore DC, Wolfe RR. Androstenedione does not stimulate muscle protein anabolism in young healthy men. J Clin Endocrinol Metab 2000; 85: 55–9.
Rouse JE, Spoerke D. Androstenedione. AltMedDex. Micromedex, Inc.
Sapienza, F. Presentation at National Association of State Controlled Substances Authorities (NASCSA). 16th Annual Education Conference, Louisville, KY, Nov. 1, 2000.
Uralets VP, Gillette PA. Over-the-counter anabolic steroids 4-androsten-3,17-dione; 4-androsten-33, 173-diol; and 19-nor-4-androsten-3,17-dione: excretion studies in men. J Anal Toxicol 1999; 23: 357–66.
Vermeulen A. Plasma levels and secretion rate of steroids with anabolic activity in man. Environ Qual Saf 1976;(5 suppl):17l-80.
Wallace MB, Lim J, Cutler A, Bucci L. Effects of dehyroepiandrosterone vs androstenedione supplmentation in men. Med Sci Sports Exerc 1999; 31: 1788–92.
Weisser H, Krieg M. In vitro inhibition of androstenedione 5-alpha-reduction by finasteride in epithelium and stroma of human benign prostatic hyperplasia. J Steroid Biochem Mol Biol 1998; 67: 49–55.
Wudy SA, Wachter UA, Homoki J, Teller WM. 173-Hydroxyprogesterone, 4-androstenedione, and testosterone profiled by routine stable isotope dilution/gas chromatography-mass spectrometry in plasma of children. Pediatr Res 1995; 38: 76–80.
Wudy SA, Wachter UA, Homoki J, Teller WM, Shackleton CHL. Androgen metabolism assessment by routine gas chromatography mass spectrometry profiling of plasma steroids: part 1, unconjugated steroids. Steroids 1992; 57: 319–24.
Yesalis CE. Medical, legal, and societal implications of androstenedione use. JAMA 1999; 281: 2043–44.
Ziegenfuss TN, Kerrigan DJ. Safety and efficacy of prohormone administration in men. Abstract presented at the American Society of Exercise Physiologists 2nd Annual Meeting, 1999.
Zurer P. Androstenedione: out of the park or out in left field? Sci Insights 1998; 76: 39.
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Duncan, J.L., Cupp, M.J., Tracy, T.S. (2003). Androstenedione and Other Over-the-Counter Steroids. In: Cupp, M.J., Tracy, T.S. (eds) Dietary Supplements. Forensic Science and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-303-3_2
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DOI: https://doi.org/10.1007/978-1-59259-303-3_2
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