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HA-SAL2

Novel Bone Graft Substitute with Composition Mimicking Bone Mineral

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Biomaterials Engineering and Devices: Human Applications

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Abstract

The advancement in orthopedic surgery is attributed, at least partially, to the continuous innovations in the field of implantable bioactive materials. Hydroxy apatite (HA) is the major inorganic component of calcified tissues in the human body (1,2), is the end product of the biological mineralization process, and has high biocompatibility with living tissues (3,4). HA and tricalcium phosphate (TCP) are regarded as bioactive implants, because of their chemical affinity, osteoconductivity, and connectivity with bone tissues. HA and TCP are the two calcium phosphates (CaPs) most commonly used in the clinic because of calcium:phosphate (Ca:P) ratios similar to those of natural bone (5). CaP ceramics are also very useful as carriers, in bioengineering applications, for supporting growth of anchorage-dependent animal cells (6). Sintered HA is also used to improve percutaneous implants, suggesting that this ceramic has also the potential to allow cell growth (7). The nature and degree of tissue response to implants depend on the characteristics of the material: chemical composition, surface texture, porosity, density, shape, and size (8–10). However, the bone and soft tissues around the implant can also be adversely affected by devicerelated factors, acting over a period of years (11,12). Indeed, biocompatibility is evaluated by host tissue responses, assessed by morphological and histological examinations of the implant site (12). Since it is difficult to examine the in vivo reactions of a specific cell type to the implant, because of various cell populations and biofactors present at the implantation site, in vitro models are also used (13–16). Recently, it was suggested that the adhesiveness and growth of cells on ceramics are regulated by a time-dependent variation of the surface structure. To this point, cell functions are significantly affected by the surface structure and chemical composition of the ceramics (9). Adhesiveness can be improved by modifying the surface, e.g., with serum proteins, fibronectin, or collagen (17,18).

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Authors
  1. Hannah Ben-Bassat
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  2. Benjamin Y. Klein
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  3. Isaac Leichter
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  4. Meir Liebergall
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  5. David Segal
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  6. Frigita Kahana
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  7. Sara Sarig
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Editor information

Editors and Affiliations

  1. Northeastern University, Boston, MA, USA

    Donald L. Wise PhD

  2. Cambridge Scientific, Inc., Cambridge, MA, USA

    Debra J. Trantolo PhD , Joseph D. Gresser PhD  & Mario V. Cattaneo PhD ,  & 

  3. Massachusetts General Hospital, Boston, MA, USA

    Kai-Uwe Lewandrowski MD

  4. Mayo Clinic, Rochester, MN, USA

    Michael J. Yaszemski MD, PhD

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© 2000 Springer Science+Business Media New York

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Ben-Bassat, H. et al. (2000). HA-SAL2. In: Wise, D.L., Trantolo, D.J., Lewandrowski, KU., Gresser, J.D., Cattaneo, M.V., Yaszemski, M.J. (eds) Biomaterials Engineering and Devices: Human Applications . Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-197-8_9

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  • DOI: https://doi.org/10.1007/978-1-59259-197-8_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-227-8

  • Online ISBN: 978-1-59259-197-8

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