Abstract
Internal fixation devices (IFDs), fabricated from biodegradable (resorbable) polymers, have several advantages, compared to metallic devices: They do not corrode; they may be constructed with moduli closer to that of normal bone than metal devices, and, thus, as a corollary, avoid stress shielding; and finally, resorbability obviates the need of a second surgical procedure for removal. However, to ensure dimensional stability during degradation, and to match modulus and strength to that of bone, it is necessary to introduce a reinforcing structure for those applications to plate fixation. One approach is to use as the major structural element a poly(d,l-lactide-co-glycolide) (PLGA), which is dispersed within a three-dimensional (3-D) network, or scaffold, of poly(propylene fumarate) (PPF) crosslinked with a vinyl monomer, such as vinyl pyrrolidone (VP).
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Gresser, J.D., Lewandrowski, KU., Trantolo, D.J., Wise, D.L. (2000). Osteointegration and Dimensional Stability of Poly(d,l—Lactide-Co-Glycolide) Implants Reinforced with Poly(Propylene Glycol-Co-Fumaric Acid). In: Wise, D.L., Trantolo, D.J., Lewandrowski, KU., Gresser, J.D., Cattaneo, M.V., Yaszemski, M.J. (eds) Biomaterials Engineering and Devices: Human Applications . Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-197-8_16
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DOI: https://doi.org/10.1007/978-1-59259-197-8_16
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