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Adult High-Grade (Diffuse) Glioma

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Molecular Pathology of Nervous System Tumors

Part of the book series: Molecular Pathology Library ((MPLB,volume 8))

Abstract

Malignant gliomas are the most common malignant brain tumors in adults. Although outcomes have improved over the past decade with the advent of new therapies, they remain aggressive and are usually incurable. Our understanding of the genetic and molecular changes that drive these tumors has grown exponentially due to data gathered by the Cancer Genome Atlas and other groups, and this data is already being translated into new therapeutic strategies. As we move further into the era of personalized medicine, an understanding of the molecular and genetic changes that drive these tumors will be more critical than ever in developing individualized treatment strategies. In this chapter, we will review our current understanding of the biology of these tumors, as well as treatments being used or under investigation to target particular biologic processes.

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Authors and Affiliations

  1. Departments of Medicine and Neurology, NYU Langone Medical Center, New York, NY, USA

    Katharine McNeill M.D.

  2. Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Unit 0085, Houston, TX, 77030, USA

    Kenneth Aldape M.D.

  3. NYU Langone Medical Center, 522 First Avenue, Smilow 1101, New York, NY, 10016, USA

    Howard A. Fine M.D.

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  1. Katharine McNeill M.D.
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  3. Howard A. Fine M.D.
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Correspondence to Katharine McNeill M.D. .

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Editors and Affiliations

  1. Associate Professor of Pediatrics and Otolaryngology, NYU Langone Medical Center, New York, New York, USA

    Matthias A. Karajannis

  2. Professor of Pathology and Neurosurgery, NYU Langone Medical Center, New York, New York, USA

    David Zagzag

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McNeill, K., Aldape, K., Fine, H.A. (2015). Adult High-Grade (Diffuse) Glioma. In: Karajannis, M., Zagzag, D. (eds) Molecular Pathology of Nervous System Tumors. Molecular Pathology Library, vol 8. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1830-0_6

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  • DOI: https://doi.org/10.1007/978-1-4939-1830-0_6

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