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Role of Novel Kidney Injury Biomarkers in Perioperative Acute Kidney Injury

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Perioperative Kidney Injury

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Abstract

The current principles of management in acute kidney injury (AKI) rely on the almost century-old gold standard of serum creatinine, which may be both delayed and nonspecific. Novel biomarkers that signal renal damage may be able to reform disease detection and management for perioperative AKI. Of the many potential candidates, interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), liver-type fatty-acid-binding protein (L-FABP), and cystatin C are at the forefront of clinical validation. Notably, these molecules can detect cases of subclinical AKI, which traditional measures may fail to identify, and may offer an opportunity for early treatment of AKI while providing valuable prognostic information. Though there is still progress to be made, the application of these biomarkers and the significant clinical changes they will bring about may be on the horizon.

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Author information

Authors and Affiliations

  1. Program of Applied Translational Research, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA

    Chirag R. Parikh MD, PhD, FASN

  2. Yale Program of Applied Translational Research, Section of Nephrology, Yale University School of Medicine, 60 Temple Street, Suite 6C, New Haven, CT, 06510, USA

    William R. Zhang BS

Authors
  1. Chirag R. Parikh MD, PhD, FASN
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  2. William R. Zhang BS
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Correspondence to Chirag R. Parikh MD, PhD, FASN .

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Editors and Affiliations

  1. Division of Nephrology and Hypertension, University of Cincinnati, Cincinnati, Ohio, USA

    Charuhas V. Thakar

  2. Program of Applied Translational Research, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

    Chirag R. Parikh

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Parikh, C.R., Zhang, W.R. (2015). Role of Novel Kidney Injury Biomarkers in Perioperative Acute Kidney Injury. In: Thakar, C., Parikh, C. (eds) Perioperative Kidney Injury. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1273-5_3

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  • DOI: https://doi.org/10.1007/978-1-4939-1273-5_3

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  • Print ISBN: 978-1-4939-1272-8

  • Online ISBN: 978-1-4939-1273-5

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