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Diabetes in Children and Adolescents

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Diabetes and Kidney Disease

Abstract

Diabetes mellitus (DM) is one of the most critical public health problems facing children today. The prevalence of DM in children is predicted to continue to rise at an alarming rate, associated with considerable health and financial burdens. This chapter presents updated data on recent progress in understanding etiology and pathogenesis of DM, developmental origins and programming of DM, acute and chronic complications, prevention and therapy of DM and associated comorbidities, as well as transition of adolescents with DM from the children’s care service into the adult health care service.

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References

  1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2011;34 Suppl 1:S62–9.

    PubMed Central  Google Scholar 

  2. Craig ME, Hattersley A, Donaghue KC. Definition, epidemiology and classification of diabetes in children and adolescents. Pediatr Diabetes. 2009;10 Suppl 12:3–12.

    PubMed  Google Scholar 

  3. Felner EI, Klitz W, Ham M, Lazaro AM, Stastny P, Dupont B, White PC. Genetic interaction among three genomic regions creates distinct contributions to early- and late-onset type 1 diabetes mellitus. Pediatr Diabetes. 2005;6(4):213–20.

    PubMed  Google Scholar 

  4. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr. 2005;146(5):693–700.

    PubMed  Google Scholar 

  5. Grinstein G, Muzumdar R, Aponte L, Vuguin P, Saenger P, DiMartino-Nardi J. Presentation and 5-year follow-up of type 2 diabetes mellitus in African-American and Caribbean-Hispanic adolescents. Horm Res. 2003;60(3):21–126.

    Google Scholar 

  6. Oeltmann JE, Liese AD, Heinze HJ, Addy CL, Mayer-Davis EJ. Prevalence of diagnosed diabetes among African-American and non-Hispanic white youth. Diabetes Care. 2003;26:2531–5.

    PubMed  Google Scholar 

  7. Copeland KC, Zeitler P, Geffner M, Guandalini C, Higgins J, Hirst K, Kaufman FR, Linder B, Marcovina S, McGuigan P, Pyle L, Tamborlane W, Willi S, TODAY Study Group. Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab. 2011;96(1):159–67.

    CAS  PubMed Central  PubMed  Google Scholar 

  8. Møller AM, Dalgaard LT, Pociot F, Nerup J, Hansen T, Pedersen O. Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes. Diabetologia. 1998;41(12):1528–31.

    PubMed  Google Scholar 

  9. Musso C, Cochran E, Moran SA, Skarulis MC, Oral EA, Taylor S, Gorden P. Clinical course of genetic diseases of the insulin receptor (type A and Rabson-Mendenhall syndromes): a 30-year prospective. Medicine (Baltimore). 2004;83(4):209–22.

    CAS  Google Scholar 

  10. Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes. 1965;14(10):619–33.

    CAS  PubMed  Google Scholar 

  11. Lambert AP, Gillespie KM, Thomson G, Cordell HJ, Todd JA, Gale EA, Bingley PJ. Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom. J Clin Endocrinol Metab. 2004;89(8):4037–43.

    CAS  PubMed  Google Scholar 

  12. Lönnrot M, Korpela K, Knip M, Ilonen J, Simell O, Korhonen S, Savola K, Muona P, Simell T, Koskela P, Hyöty H. Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: the Finnish Diabetes Prediction and Prevention Study. Diabetes. 2000;49(8):1314–8.

    PubMed  Google Scholar 

  13. Atkinson MA, Mclaren NK. The pathogenesis of insulin dependent diabetes mellitus. N Engl J Med. 1994;331(21):1428–36.

    CAS  PubMed  Google Scholar 

  14. Flood RG, Chiang VW. Rate and prediction of infection in children with diabetic ketoacidosis. Am J Emerg Med. 2001;19:270–3.

    CAS  PubMed  Google Scholar 

  15. Umpaichitra V, Banerji MA, Castells S. Autoantibodies in children with type 2 diabetes mellitus. J Pediatr Endocrinol Metab. 2002;15 Suppl 1:525–30.

    CAS  PubMed  Google Scholar 

  16. Bonal C, Herrera PL. Genes controlling pancreas ontogeny. Int J Dev Biol. 2008;52(7):823–35.

    CAS  PubMed  Google Scholar 

  17. Oliver-Krasinski JM, Stoffers DA. On the origin of the beta cell. Genes Dev. 2008;22(15):1998–2021.

    CAS  PubMed Central  PubMed  Google Scholar 

  18. Jørgensen MC, Ahnfelt-Rønne J, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J. An illustrated review of early pancreas development in the mouse. Endocr Rev. 2007;28(6):685–705.

    PubMed  Google Scholar 

  19. Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P. Early pattern of differentiation in the human pancreas. Diabetes. 2000;49(2):225–32.

    CAS  PubMed  Google Scholar 

  20. Pearl EJ, Horb ME. Promoting ectopic pancreatic fates: pancreas development and future diabetes therapies. Clin Genet. 2008;74(4):316–24.

    CAS  PubMed  Google Scholar 

  21. Mastracci TL, Sussel L. The Endocrine Pancreas: insights into development, differentiation and diabetes. Wiley Interdiscip Rev Membr Transp Signal. 2012;1(5):609–28.

    CAS  PubMed Central  PubMed  Google Scholar 

  22. Solar M, Cardalda C, Houbracken I, Martín M, Maestro MA, De Medts N, Xu X, Grau V, Heimberg H, Bouwens L, Ferrer J. Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev Cell. 2009;17(6):849–60.

    CAS  PubMed  Google Scholar 

  23. Carolan PJ, Melton DA. New findings in pancreatic and intestinal endocrine development to advance regenerative medicine. Curr Opin Endocrinol Diabetes Obes. 2013;20(1):1–7.

    CAS  PubMed  Google Scholar 

  24. Pilgaard K, Færch K, Carstensen B, Poulsen P, Pisinger C, Pedersen O, Witte DR, Hansen T, Jørgensen T, Vaag A. Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes. Diabetologia. 2010;53(12):2526–30.

    CAS  PubMed  Google Scholar 

  25. Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia. 1993;36(1):62–7.

    CAS  PubMed  Google Scholar 

  26. Wei JN, Sung FC, Li CY, Chang CH, Lin RS, Lin CC, Chiang CC, Chuang LM. Low birth weight and high birth weight infants are both at an increased risk to have type 2 diabetes among schoolchildren in Taiwan. Diabetes Care. 2003;26(2):343–8.

    PubMed  Google Scholar 

  27. Crowther NJ, Cameron N, Trusler J, Gray IP. Association between poor glucose tolerance and rapid post natal weight gain in seven-year-old children. Diabetologia. 1998;41(10):1163–7.

    CAS  PubMed  Google Scholar 

  28. Crowther NJ, Cameron N, Trusler J, Toman M, Norris SA, Gray IP. Influence of catch-up growth on glucose tolerance and beta-cell function in 7-year-old children: results from the birth to twenty study. Pediatrics. 2008;121(6):e1715–22.

    PubMed  Google Scholar 

  29. Poulsen P, Vaag AA, Kyvik KO, Møller Jensen D, Beck-Nielsen H. Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs. Diabetologia. 1997;40(4):439–46.

    CAS  PubMed  Google Scholar 

  30. Forsén T, Eriksson J, Tuomilehto J, Reunanen A, Osmond C, Barker D. The fetal and childhood growth of persons who develop type 2 diabetes. Ann Intern Med. 2000;133(3):176–81.

    PubMed  Google Scholar 

  31. Silverman BL, Rizzo TA, Cho NH, Metzger BE. Long-term effects of the intrauterine environment. The Northwestern University Diabetes in Pregnancy Center. Diabetes Care. 1998;21 Suppl 2:B142–8.

    PubMed  Google Scholar 

  32. Magaton A, Gil FZ, Casarini DE, Cavanal Mde F, Gomes GN. Maternal diabetes mellitus—early consequences for the offspring. Pediatr Nephrol. 2007;22(1):37–43.

    PubMed  Google Scholar 

  33. Rocha SO, Gomes GN, Forti AL, do Carmo Pinho Franco M, Fortes ZB, de Fátima Cavanal M, Gil FZ. Long-term effects of maternal diabetes on vascular reactivity and renal function in rat male offspring. Pediatr Res. 2005;58(6):1274–9.

    PubMed  Google Scholar 

  34. Nottke A, Colaiácovo MP, Shi Y. Developmental roles of the histone lysine demethylases. Development. 2009;136(6):879–89.

    CAS  PubMed Central  PubMed  Google Scholar 

  35. Smith CL. A shifting paradigm: histone deacetylases and transcriptional activation. Bioessays. 2008;30(1):15–24.

    CAS  PubMed  Google Scholar 

  36. Rees WD, Hay SM, Brown DS, Antipatis C, Palmer RM. Maternal protein deficiency causes hypermethylation of DNA in the livers of rat fetuses. J Nutr. 2000;130(7):1821–6.

    CAS  PubMed  Google Scholar 

  37. Suter M, Ma J, Harris A, Patterson L, Brown KA, Shope C, Showalter L, Abramovici A, Aagaard-Tillery KM. Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression. Epigenetics. 2011;6(11):1284–94.

    CAS  PubMed Central  PubMed  Google Scholar 

  38. Park JH, Stoffers DA, Nicholls RD, Simmons RA. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. J Clin Invest. 2008;118(6):2316–24.

    CAS  PubMed Central  PubMed  Google Scholar 

  39. Sandovici I, Smith NH, Nitert MD, Ackers-Johnson M, Uribe-Lewis S, Ito Y, Jones RH, Marquez VE, Cairns W, Tadayyon M, O’Neill LP, Murrell A, Ling C, Constância M, Ozanne SE. Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proc Natl Acad Sci U S A. 2011;108(13):5449–54.

    CAS  PubMed Central  PubMed  Google Scholar 

  40. Raychaudhuri N, Raychaudhuri S, Thamotharan M, Devaskar SU. Histone code modifications repress glucose transporter 4 expression in the intrauterine growth-restricted offspring. J Biol Chem. 2008;283(20):13611–26.

    CAS  PubMed Central  PubMed  Google Scholar 

  41. Vélez MP, Santos IS, Matijasevich A, Gigante D, Gonçalves H, Barros FC, Victora CG. Maternal low birth weight and adverse perinatal outcomes: the 1982 Pelotas Birth Cohort Study, Brazil. Rev Panam Salud Publica. 2009;26(2):112–9.

    PubMed  Google Scholar 

  42. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359(1):61–73.

    CAS  PubMed Central  PubMed  Google Scholar 

  43. Quinn M, Fleischman A, Rosner B, Nigrin DJ, Wolfsdorf JI. Characteristics at diagnosis of type 1 diabetes in children younger than 6 years. J Pediatr. 2006;148(3):366–71.

    PubMed  Google Scholar 

  44. Kong AS, Williams RL, Rhyne R, Urias-Sandoval V, Cardinali G, Weller NF, Skipper B, Volk R, Daniels E, Parnes B, McPherson L. Acanthosis Nigricans: high prevalence and association with diabetes in a practice-based research network consortium—a PRImary care Multi-Ethnic network (PRIME Net) study. J Am Board Fam Med. 2010;23(4):476–81.

    PubMed Central  PubMed  Google Scholar 

  45. Lipton RB, Drum ML, Danielson KK, Greeley SA, Bell GI, Hagopian WA. Onset features and subsequent clinical evolution of childhood diabetes over several years. Pediatr Diabetes. 2011;12(4 Pt 1):326–34.

    PubMed Central  PubMed  Google Scholar 

  46. Chen F, Wang Y, Shan X, Cheng H, Hou D, Zhao X, Wang T, Zhao D, Mi J. Association between childhood obesity and metabolic syndrome: evidence from a large sample of Chinese children and adolescents. PLoS One. 2012;7(10):e47380.

    CAS  PubMed Central  PubMed  Google Scholar 

  47. Foster DW, McGarry JD. The metabolic derangements and treatment of diabetic ketoacidosis. N Engl J Med. 1983;309(3):159–69.

    CAS  PubMed  Google Scholar 

  48. Wolfsdorf J, Craig ME, Daneman D, Dunger D, Edge J, Lee W, Rosenbloom A, Sperling M, Hanas R. Diabetic ketoacidosis in children and adolescents with diabetes. Pediatr Diabetes. 2009;10 Suppl 12:118–33.

    PubMed  Google Scholar 

  49. Lévy-Marchal C, Papoz L, de Beaufort C, Doutreix J, Froment V, Voirin J, Czernichow P. Clinical and laboratory features of type 1 diabetic children at the time of diagnosis. Diabet Med. 1992;9(3):279–84.

    PubMed  Google Scholar 

  50. Muir AB, Quisling RG, Yang MC, Rosenbloom AL. Cerebral edema in childhood diabetic ketoacidosis: natural history, radiographic findings, and early identification. Diabetes Care. 2004;27(7):1541–6.

    PubMed  Google Scholar 

  51. Glaser N, Barnett P, McCaslin I, Nelso ND, Trainor J, Louie J, Kaufman F, Quayle K, Roback M, Malley R, Kuppermann N, Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. N Engl J Med. 2001;344(4):264–9.

    CAS  PubMed  Google Scholar 

  52. Curtis JR, To T, Muirhead S, Cummings E, Daneman D. Recent trends in hospitalization for diabetic ketoacidosis in Ontario children. Diabetes Care. 2002;25(9):1591–6.

    PubMed  Google Scholar 

  53. Bagdure D, Rewers A, Campagna E, Sills MR. Epidemiology of hyperglycemic hyperosmolar syndrome in children hospitalized in USA. Pediatr Diabetes. 2013;14(1):18–24.

    PubMed  Google Scholar 

  54. Rodacki M, Pereira JR, Nabuco de Oliveira AM, Barone B, Mac Dowell R, Perricelli P, Bravo MT, de Oliveira MM, Brum JD, Belem LC, de Ornellas PG, Berardo RS, Luescher J, Campos L, Vangelotti Ade M, Kupfer R, Zajdenverg L, Milech A, Paulo de Oliveira JE. Ethnicity and young age influence the frequency of diabetic ketoacidosis at the onset of type 1 diabetes. Diabetes Res Clin Pract. 2007;78(2):259–62.

    CAS  PubMed  Google Scholar 

  55. American Diabetes Association. Standards of medical care in diabetes. Diabetes Care. 2011;34 Suppl 1:S11–21.

    PubMed Central  Google Scholar 

  56. Hattersley A, Bruining J, Shield J, Njolstad P, Donaghue KC. The diagnosis and management of monogenic diabetes in children and adolescents. Pediatr Diabetes. 2009;10 Suppl 12:33–42.

    PubMed  Google Scholar 

  57. Dabelea D, Pihoker C, Talton JW, D’Agostino Jr RB, Fujimoto W, Klingensmith GJ, Lawrence JM, Linder B, Marcovina SM, Mayer-Davis EJ, Imperatore G, Dolan LM, SEARCH for Diabetes in Youth Study. Etiological approach to characterization of diabetes type: the SEARCH for Diabetes in Youth Study. Diabetes Care. 2011;34(7):1628–34.

    PubMed Central  PubMed  Google Scholar 

  58. Gat-Yablonski G, Shalitin S, Phillip M. Maturity onset diabetes of the young. Pediatr Endocrinol Rev. 2006;3 Suppl 3:514–9.

    PubMed  Google Scholar 

  59. Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M, Bell GI. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature. 1996;384(6608):458–64.

    CAS  PubMed  Google Scholar 

  60. Froguel P, Zouali H, Vionnet N, Velho G, Vaxillaire M, Sun F, Lesage S, Stoffel M, Takeda J, Passa P. Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. N Engl J Med. 1993;328(10):697–702.

    CAS  PubMed  Google Scholar 

  61. Macfarlane WM, Frayling TM, Ellard S, Evans JC, Allen LI, Bulman MP, Ayres S, Shepherd M, Clark P, Millward A, Demaine A, Wilkin T, Docherty K, Hattersley AT. Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. J Clin Invest. 1999;104(9):R33–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  62. Bellanné-Chantelot C, Chauveau D, Gautier JF, Dubois-Laforgue D, Clauin S, Beaufils S, Wilhelm JM, Boitard C, Noël LH, Velho G, Timsit J. Clinical spectrum associated with hepatocyte nuclear factor-1beta mutations. Ann Intern Med. 2004;140(7):510–4.

    PubMed  Google Scholar 

  63. Bingham C, Ellard S, van’t Hoff WG, Simmonds HA, Marinaki AM, Badman MK, Winocour PH, Stride A, Lockwood CR, Nicholls AJ, Owen KR, Spyer G, Pearson ER, Hattersley AT. Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1beta gene mutation. Kidney Int. 2003;63(5):1645–9.

    CAS  PubMed  Google Scholar 

  64. Hiesberger T, Bai Y, Shao X, McNally BT, Sinclair AM, Tian X, Somlo S, Igarashi P. Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice. J Clin Invest. 2004;113(6):814–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  65. Kristinsson SY, Thorolfsdottir ET, Talseth B, Steingrimsson E, Thorsson AV, Helgason T, Hreidarsson AB, Arngrimsson R. MODY in Iceland is associated with mutations in HNF-1alpha and a novel mutation in NeuroD1. Diabetologia. 2001;44(11):2098–102.

    CAS  PubMed  Google Scholar 

  66. Gardner RJ, Mackay DJ, Mungall AJ, Polychronakos C, Siebert R, Shield JP, Temple IK, Robinson DO. An imprinted locus associated with transient neonatal diabetes mellitus. Hum Mol Genet. 2000;9(4):589–96.

    CAS  PubMed  Google Scholar 

  67. Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, Howard N, Srinivasan S, Silva JM, Molnes J, Edghill EL, Frayling TM, Temple IK, Mackay D, Shield JP, Sumnik Z, van Rhijn A, Wales JK, Clark P, Gorman S, Aisenberg J, Ellard S, Njølstad PR, Ashcroft FM, Hattersley AT. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med. 2004;350(18):1838–49.

    CAS  PubMed  Google Scholar 

  68. Bae KW, Kim BE, Choi JH, Lee JH, Park YS, Kim GH, Yoo HW, Seo JJ. A novel mutation and unusual clinical features in a patient with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Eur J Pediatr. 2011;170(12):1611–5.

    PubMed  Google Scholar 

  69. Donovan LE, Severin NE. Maternally inherited diabetes and deafness in a North American kindred: tips for making the diagnosis and review of unique management issues. J Clin Endocrinol Metab. 2006;91(12):4737–41.

    CAS  PubMed  Google Scholar 

  70. Huopio H, Reimann F, Ashfield R, Komulainen J, Lenko HL, Rahier J, Vauhkonen I, Kere J, Laakso M, Ashcroft F, Otonkoski T. Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1. J Clin Invest. 2000;106(7):897–902.

    CAS  PubMed Central  PubMed  Google Scholar 

  71. Robbins DC, Shoelson SE, Rubenstein AH, Tager HS. Familial hyperproinsulinemia. Two cohorts secreting indistinguishable type II intermediates of proinsulin conversion. J Clin Invest. 1984;73(3):714–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  72. Tager H, Given B, Baldwin D, Mako M, Markese J, Rubenstein A, Olefsky J, Kobayashi M, Kolterman O, Poucher R. A structurally abnormal insulin causing human diabetes. Nature. 1979;281(5727):122–7.

    CAS  PubMed  Google Scholar 

  73. Moller DE, Flier JS. Insulin resistance—mechanisms, syndromes, and implications. N Engl J Med. 1991;325(13):938–44.

    CAS  PubMed  Google Scholar 

  74. Owen KR, Donohoe M, Ellard S, Hattersley AT. Response to treatment with rosiglitazone in familial partial lipodystrophy due to a mutation in the LMNA gene. Diabet Med. 2003;20(10):823–7.

    PubMed  Google Scholar 

  75. Cremers CW, Wijdeveld PG, Pinckers AJ. Juvenile diabetes mellitus, optic atrophy, hearing loss, diabetes insipidus, atonia of the urinary tract and bladder, and other abnormalities (Wolfram syndrome). A review of 88 cases from the literature with personal observations on 3 new patients. Acta Paediatr Scand Suppl. 1977;264:1–16.

    PubMed  Google Scholar 

  76. Inoue H, Tanizawa Y, Wasson J, Behn P, Kalidas K, Bernal-Mizrachi E, Mueckler M, Marshall H, Donis-Keller H, Crock P, Rogers D, Mikuni M, Kumashiro H, Higashi K, Sobue G, Oka Y, Permutt MA. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet. 1998;20(2):143–7.

    CAS  PubMed  Google Scholar 

  77. Chaussenot A, Bannwarth S, Rouzier C, Vialettes B, Mkadem SA, Chabrol B, Cano A, Labauge P, Paquis-Flucklinger V. Neurologic features and genotype-phenotype correlation in Wolfram syndrome. Ann Neurol. 2011;69(3):501–8.

    CAS  PubMed  Google Scholar 

  78. Iyer S, Korada M, Rainbow L, Kirk J, Brown RM, Shaw N, Barrett TG. Wolcott-Rallison syndrome: a clinical and genetic study of three children, novel mutation in EIF2AK3 and a review of the literature. Acta Paediatr. 2004;93(9):1195–201.

    CAS  PubMed  Google Scholar 

  79. Bangstad HJ, Danne T, Deeb LC, Jarosz-Chobot P, Urakami T, Hanas R. International Society for Pediatric and Adolescent Diabetes. SPAD Clinical Practice Consensus Guidelines 2006–2007. Insulin treatment in children and adolescents with diabetes. Pediatr Diabetes. 2007;8(2):88–102.

    PubMed  Google Scholar 

  80. Rosenbloom AL, Silverstein JH, Amemiya S, Zeitler P, Klingensmith GJ, International Society for Pediatric and Adolescent Diabetes. ISPAD Clinical Practice Consensus Guidelines 2006–2007. Type 2 diabetes mellitus in the child and adolescent. Pediatr Diabetes. 2008;9(5):512–26.

    CAS  PubMed  Google Scholar 

  81. Hsia DS, Fallon SC, Brandt ML. Adolescent bariatric surgery. Arch Pediatr Adolesc Med. 2012;166(8):757–66.

    PubMed  Google Scholar 

  82. Inge TH, Miyano G, Bean J, Helmrath M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt ML, Dolan LM. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics. 2009;123(1):214–22.

    PubMed  Google Scholar 

  83. Roberts MD, Slover RH, Chase HP. Diabetic ketoacidosis with intracerebral complications. Pediatr Diabetes. 2001;2(3):109–14.

    CAS  PubMed  Google Scholar 

  84. Zung A, Glaser B, Nimri R, Zadik Z. Glibenclamide treatment in permanent neonatal diabetes mellitus due to an activating mutation in Kir6.2. J Clin Endocrinol Metab. 2004;89(11):5504–7.

    CAS  PubMed  Google Scholar 

  85. Pearson ER, Starkey BJ, Powell RJ, Gribble FM, Clark PM, Hattersley AT. Genetic cause of hyperglycaemia and response to treatment in diabetes. Lancet. 2003;362(9392):1275–81.

    CAS  PubMed  Google Scholar 

  86. Ozdemir MA, Akcakus M, Kurtoglu S, Gunes T, Torun YA. TRMA syndrome (thiamine-responsive megaloblastic anemia): a case report and review of the literature. Pediatr Diabetes. 2002;3(4):205–9.

    PubMed  Google Scholar 

  87. Cooke DW, Plotnick L. Type 1 diabetes mellitus in pediatrics. Pediatr Rev. 2008;29(11):374–84.

    PubMed  Google Scholar 

  88. Kershnar AK, Daniels SR, Imperatore G, Palla SL, Petitti DB, Pettitt DJ, Marcovina S, Dolan LM, Hamman RF, Liese AD, Pihoker C, Rodriguez BL. Lipid abnormalities are prevalent in youth with type 1 and type 2 diabetes: the SEARCH for Diabetes in Youth Study. J Pediatr. 2006;149(3):314–9.

    CAS  PubMed  Google Scholar 

  89. Pinhas-Hamiel O, Zeitler P. Acute and chronic complications of type 2 diabetes mellitus in children and adolescents. Lancet. 2007;369(9575):1823–7.

    PubMed  Google Scholar 

  90. Rodriguez BL, Dabelea D, Liese AD, Fujimoto W, Waitzfelder B, Liu L, Bell R, Talton J, Snively BM, Kershnar A, Urbina E, Daniels S, Imperatore G. Prevalence and correlates of elevated blood pressure in youth with diabetes mellitus: the SEARCH for diabetes in youth study. J Pediatr. 2010;157(2):245–51.

    PubMed  Google Scholar 

  91. Gungor N, Thompson T, Sutton-Tyrrell K, Janosky J, Arslanian S. Early signs of cardiovascular disease in youth with obesity and type 2 diabetes. Diabetes Care. 2005;28(5):1219–21.

    PubMed Central  PubMed  Google Scholar 

  92. Ettinger LM, Freeman K, DiMartino-Nardi JR, Flynn JT. Microalbuminuria and abnormal ambulatory blood pressure in adolescents with type 2 diabetes mellitus. J Pediatr. 2005;147(1):67–73.

    CAS  PubMed  Google Scholar 

  93. Lurbe E, Redon J, Kesani A, Pascual JM, Tacons J, Alvarez V, Batlle D. Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes. N Engl J Med. 2002;347(11):797–805.

    CAS  PubMed  Google Scholar 

  94. Wilfley D, Berkowitz R, Goebel-Fabbri A, Hirst K, Ievers-Landis C, Lipman TH, Marcus M, Ng D, Pham T, Saletsky R, Schanuel J, Van Buren D. Binge eating, mood, and quality of life in youth with type 2 diabetes: baseline data from the today study. Diabetes Care. 2011;34(4):858–62.

    PubMed  Google Scholar 

  95. Stewart SM, Rao U, White P. Depression and diabetes in children and adolescents. Curr Opin Pediatr. 2005;17(5):626–31.

    PubMed  Google Scholar 

  96. Sjöberg L, Pitkäniemi J, Haapala L, Kaaja R, Tuomilehto J. Fertility in people with childhood-onset type 1 diabetes. Diabetologia. 2013;56(1):78–81.

    PubMed  Google Scholar 

  97. Holmquist P, Torffvit O. Urinary transforming growth factor-beta(1), collagen IV and the effect of insulin in children at diagnosis of diabetes mellitus. Scand J Urol Nephrol. 2009;43(2):142–7.

    CAS  PubMed  Google Scholar 

  98. Rademacher ER, Sinaiko AR. Albuminuria in children. Curr Opin Nephrol Hypertens. 2009;18(3):246–51.

    CAS  PubMed  Google Scholar 

  99. Amin R, Widmer B, Prevost AT, Schwarze P, Cooper J, Edge J, Marcovecchio L, Neil A, Dalton RN, Dunger DB. Risk of microalbuminuria and progression to macroalbuminuria in a cohort with childhood onset type 1 diabetes: prospective observational study. BMJ. 2008;336(7646):697–703.

    PubMed Central  PubMed  Google Scholar 

  100. Dart AB, Sellers EA, Martens PJ, Rigatto C, Brownell MD, Dean HJ. High burden of kidney disease in youth-onset type 2 diabetes. Diabetes Care. 2012;35(6):1265–71.

    PubMed Central  PubMed  Google Scholar 

  101. Möllsten A, Svensson M, Waernbaum I, Berhan Y, Schön S, Nyström L, Arnqvist HJ, Dahlquist G, Swedish Childhood Diabetes Study Group. Cumulative risk, age at onset, and sex-specific differences for developing end-stage renal disease in young patients with type 1 diabetes: a nationwide population-based cohort study. Diabetes. 2010;59(7):1803–8.

    PubMed Central  PubMed  Google Scholar 

  102. Nordwall M, Bojestig M, Arnqvist HJ, Ludvigsson J. Declining incidence of severe retinopathy and persisting decrease of nephropathy in an unselected population of type 1 diabetes-the Linkoping Diabetes Complications Study. Diabetologia. 2004;47:1266–72.

    CAS  PubMed  Google Scholar 

  103. Basevi V, Di Mario S, Morciano C, Nonino F, Magrini N. Standards of medical care in diabetes-2011. Diabetes Care. May;34 Suppl 1:S11–61.

    Google Scholar 

  104. Hilgers KF, Dötsch J, Rascher W, Mann JF. Treatment strategies in patients with chronic renal disease: ACE inhibitors, angiotensin receptor antagonists, or both? Pediatr Nephrol. 2004;19(9):956–61.

    PubMed  Google Scholar 

  105. Perrin NE, Jaremko GA, Berg UB. The effects of candesartan on diabetes glomerulopathy: a double-blind, placebo-controlled trial. Pediatr Nephrol. 2008;23(6):947–54.

    PubMed  Google Scholar 

  106. Perrin NE, Torbjörnsdotter T, Jaremko GA, Berg UB. Risk markers of future microalbuminuria and hypertension based on clinical and morphological parameters in young type 1 diabetes patients. Pediatr Diabetes. 2010;11(5):305–13.

    PubMed  Google Scholar 

  107. Becker BN, Rush SH, Dykstra DM, Becker YT, Port FK. Preemptive transplantation for patients with diabetes-related kidney disease. Arch Intern Med. 2006;166(1):44–8.

    PubMed  Google Scholar 

  108. Greenspan LC, Gitelman SE, Leung MA, Glidden DV, Mathias RS. Increased incidence in post-transplant diabetes mellitus in children: a case-control analysis. Pediatr Nephrol. 2002;17(1):1–5.

    PubMed  Google Scholar 

  109. Davis CL, Pollock NK, Waller JL, Allison JD, Dennis BA, Bassali R, Meléndez A, Boyle CA, Gower BA. Exercise dose and diabetes risk in overweight and obese children: a randomized controlled trial. JAMA. 2012;308(11):1103–12.

    CAS  PubMed Central  PubMed  Google Scholar 

  110. Silverstein J, Klingensmith G, Copeland K, Plotnick L, Kaufman F, Laffel L, Deeb L, Grey M, Anderson B, Holzmeister LA, Clark N, American Diabetes Association. Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. Diabetes Care. 2005;28(1):186–212.

    PubMed  Google Scholar 

  111. Thomson G, Robinson WP, Kuhner MK, Joe S, MacDonald MJ, Gottschall JL, Barbosa J, Rich SS, Bertrams J, Baur MP. Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus. Am J Hum Genet. 1988;43(6):799–816.

    CAS  PubMed Central  PubMed  Google Scholar 

  112. LaGasse JM, Brantley MS, Leech NJ, Rowe RE, Monks S, Palmer JP, Nepom GT, McCulloch DK, Hagopian WA, Washington State Diabetes Prediction Study. Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington State Diabetes Prediction Study. Diabetes Care. 2002;25(3):505–11.

    PubMed  Google Scholar 

  113. Ongagna JC, Levy-Marchal C. Sensitivity at diagnosis of combined beta-cell autoantibodies in insulin-dependent diabetic children. French Registry of IDDM in Children Study Group. Diabetes Metab. 1997;23(2):155–60.

    CAS  PubMed  Google Scholar 

  114. Bingley PJ. Interactions of age, islet cell antibodies, insulin autoantibodies, and first-phase insulin response in predicting risk of progression to IDDM in ICA+ relatives: the ICARUS data set. Islet Cell Antibody Register Users Study. Diabetes. 1996;45(12):1720–8.

    CAS  PubMed  Google Scholar 

  115. Barker JM, McFann K, Harrison LC, Fourlanos S, Krischer J, Cuthbertson D, Chase HP, Eisenbarth GS, DPT-1 Study Group. Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing. J Pediatr. 2007;150(1):31–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  116. van Esch SC, Cornel MC, Snoek FJ. “I am pregnant and my husband has diabetes. Is there a risk for my child?” A qualitative study of questions asked by email about the role of genetic susceptibility to diabetes. BMC Public Health. 2010;10:688–92.

    PubMed Central  PubMed  Google Scholar 

  117. Lee PA, Chernausek SD, Hokken-Koelega AC, Czernichow P, International Small for Gestational Age Advisory Board. International Small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age. Pediatrics. 2003;111(6 Pt 1):1253–61.

    PubMed  Google Scholar 

  118. Leger J, Oury JF, Noel M, Baron S, Benali K, Blot P, Czernichow P. Growth factors and intrauterine growth retardation. I. Serum growth hormone, insulin-like growth factor (IGF)-I, IGF-II, and IGF binding protein 3 levels in normally grown and growth-retarded human fetuses during the second half of gestation. Pediatr Res. 1996;40(1):94–100.

    CAS  PubMed  Google Scholar 

  119. Salamon KS, Brouwer AM, Fox MM, Olson KA, Yelich-Koth SL, Fleischman KM, Hains AA, Davies WH, Kichler JC. Experiencing type 2 diabetes mellitus: qualitative analysis of adolescents’ concept of illness, adjustment, and motivation to engage in self-care behaviors. Diabetes Educ. 2012;38(4):543–51.

    PubMed  Google Scholar 

  120. Pound N, Sturrock ND, Jeffcoate WJ. Age related changes in glycated haemoglobin in patients with insulin-dependent diabetes mellitus. Diabet Med. 1996;13(6):510–3.

    CAS  PubMed  Google Scholar 

  121. Fleming E, Carter B, Gillibrand W. The transition of adolescents with diabetes from the children’s health care service into the adult health care service: a review of the literature. J Clin Nurs. 2002;11(5):560–7.

    PubMed  Google Scholar 

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Yosypiv, I.V. (2014). Diabetes in Children and Adolescents. In: Lerma, E., Batuman, V. (eds) Diabetes and Kidney Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0793-9_6

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