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The Background History of Diabetic Nephropathy

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Diabetes and Kidney Disease

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Abstract

This chapter presents an overview of the background history of diabetic nephropathy. The discovery of diabetic renal disease was a gradual process and the definition of diabetic nephropathy has changed over time. Initial studies of renal biopsies, radioimmunoassay, and the concept of micro- and macroalbuminuria are highlighted, as well as the discovery of renin–angiotensin–aldosterone system (RAAS). Landmark trials focusing on how diabetic nephropathy could be improved using pharmacologic blockade of RAAS are reviewed. Diabetes is the most common cause of end-stage renal disease in Western countries, and trials that highlight the benefit of treating hyperglycemia are presented.

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Authors and Affiliations

  1. Department of Medicine, Section of Endocrinology, Tulane University, 930 Poydras Street, Apt 1709, New Orleans, LA, 70112, USA

    Michelle Haggar M.D. & Vivian Fonseca M.D.

Authors
  1. Michelle Haggar M.D.
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  2. Vivian Fonseca M.D.
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Correspondence to Michelle Haggar M.D. .

Editor information

Editors and Affiliations

  1. University of Illinois, Chicago, Illinois, USA

    Edgar V. Lerma

  2. Nephrology Section, Tulane University Medical School, New Orleans, Louisiana, USA

    Vecihi Batuman

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Haggar, M., Fonseca, V. (2014). The Background History of Diabetic Nephropathy. In: Lerma, E., Batuman, V. (eds) Diabetes and Kidney Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0793-9_1

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  • DOI: https://doi.org/10.1007/978-1-4939-0793-9_1

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