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Neonatal Lupus

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Contraception and Pregnancy in Patients with Rheumatic Disease

Abstract

Neonatal lupus is a model of passively acquired autoimmunity in which maternal anti-SSA/Ro antibodies cross the placenta and cause various clinical manifestations in the fetus. In this chapter we will describe the clinical manifestations with a focus on the most serious form of neonatal lupus: the cardiac manifestations, comprised of advanced block and occasionally disease that extends beyond the AV node. A review of the current models of pathophysiology will be discussed in addition to potential treatment and prevention options.

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Abbreviations

Anti-TG:

Anti-thyroglobulin

Anti-TPO:

Anti-thyroperoxidase

CHB:

Congenital heart block

EFE:

Endocardial fibroelastosis

HCQ:

Hydroxychloroquine

La48:

48 kDa SSB/La

LTCC:

L-type cardiac calcium channels

MHC:

Major histocompatibility complex

NL:

Neonatal lupus

Ro52:

52 kDa SSA/Ro

Ro60:

60 kDa SSA/Ro

RRNL:

Research registry for neonatal lupus

SLE:

Systemic lupus erythematosus

SS:

Sjögren’s syndrome

UAS:

Undifferentiated autoimmune syndrome

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Acknowledgments

The authors are grateful to Amanda Zink for assistance in preparing the manuscript.

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Authors and Affiliations

  1. Albert Einstein College of Medicine, Department of Rheumatology, Montefiore Medical Specialists, 495 Central Park Avenue, Scarsdale, NY, 10583, USA

    Barbara Mendez M.D.

  2. NYU Langone Medical Center, Center for Musculoskeletal Care, 333 East 38th Street, 4th Floor, New York, NY, 10016, USA

    Amit Saxena M.D.

  3. Department of Rheumatology, New York University School of Medicine, 301 East 17th Street, Suite 1410, New York, NY, 10003, USA

    Jill P. Buyon M.D.

  4. Department of Rheumatology, New York University School of Medicine, 301 East 17th Street, Room 1611B, New York, NY, 10003, USA

    Peter M. Izmirly M.D.

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  1. Barbara Mendez M.D.
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  2. Amit Saxena M.D.
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  3. Jill P. Buyon M.D.
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  4. Peter M. Izmirly M.D.
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Correspondence to Peter M. Izmirly M.D. .

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Editors and Affiliations

  1. Division of Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, New York, USA

    Lisa R. Sammaritano

  2. Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA

    Bonnie L. Bermas

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Mendez, B., Saxena, A., Buyon, J.P., Izmirly, P.M. (2014). Neonatal Lupus. In: Sammaritano, L., Bermas, B. (eds) Contraception and Pregnancy in Patients with Rheumatic Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0673-4_13

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