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Air Pollution and Oxidative Stress in Allergic Airway Diseases

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Studies on Respiratory Disorders

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Abstract

With 30–40 % of the world’s population suffering from allergic diseases and with the increasing trends of this noncommunicable disease, especially in children in both the developed and developing, allergic diseases comprise a global public health issue. The increase in prevalence of allergic diseases contributes to reduced quality of life of the patients and increased socioeconomic costs. Several factors contribute to this rise in prevalence of allergic diseases including less exposure to infections in early life, change in lifestyles, urbanization, environmental pollution, climate change, and reduced biodiversity. Epidemiological and toxicology studies have demonstrated that air pollution-induced oxidative stress is increased in allergic airway diseases like asthma, and this can be a critical contributor to asthma development and can initiate various intracellular signaling pathways that lead to a break in immune tolerance and exaggerated allergic inflammation. Controlling environmental trigger factors, air pollution, and subsequent oxidative stress is critical for effectively managing and reducing the burden of allergic airway diseases.

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Authors and Affiliations

  1. Division of Allergy, Department of Pediatrics, Nippon Medical School, 4F, Yayoi Ichigokan, 1-4-10, Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan

    Ruby Pawankar M.D., Ph.D., F.R.C.P., F.A.A.A.A.I.

  2. Ozu ENT Clinic, Shizuoka, Japan

    Chika Ozu M.D.

  3. Department of Pediatrics, Nippon Medical School, Tokyo, Japan

    Miyuki Hayashi M.D., Ph.D. & Shingo Yamanishi M.D., Ph.D.

Authors
  1. Ruby Pawankar M.D., Ph.D., F.R.C.P., F.A.A.A.A.I.
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  2. Chika Ozu M.D.
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  3. Miyuki Hayashi M.D., Ph.D.
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  4. Shingo Yamanishi M.D., Ph.D.
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Correspondence to Ruby Pawankar M.D., Ph.D., F.R.C.P., F.A.A.A.A.I. .

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Editors and Affiliations

  1. Department of Biotechnology, National Institute of Immunology, New Delhi, India

    Nirmal K. Ganguly

  2. Department of Pulmonary Medicine, Postgraduate Institute of Medical Educat, Chandigarh, India

    Surinder K. Jindal

  3. Department of Medicine and Oncology, Johns Hopkins College of Medicine, Baltimore, Maryland, USA

    Shyam Biswal

  4. National Heart & Lung Institute, Imperial College London, London, United Kingdom

    Peter J. Barnes

  5. Department of Pediatrics, Nippon Medical School, Tokyo, Japan

    Ruby Pawankar

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Pawankar, R., Ozu, C., Hayashi, M., Yamanishi, S. (2014). Air Pollution and Oxidative Stress in Allergic Airway Diseases. In: Ganguly, N., Jindal, S., Biswal, S., Barnes, P., Pawankar, R. (eds) Studies on Respiratory Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0497-6_9

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