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The Power of the Tumor Microenvironment: A Systemic Approach for a Systemic Disease

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Mathematical Oncology 2013

Abstract

Cancer is increasingly recognized as not solely a disease of the genes and chromosomes but as a systemic disease that affects numerous components of the host including blood vessel formation, immune cell function, and nutrient recycling. This review summarizes a variety of time-dependent mathematical models that focus on the consequences of tumor growth within an evolving microenvironment, represented by a dynamic carrying capacity. Transcending the specifics of each model, their overview reveals that the key to tumor control really lies in controlling the support furnished the tumor by its microenvironment.

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Authors and Affiliations

  1. Center of Cancer Systems Biology, GeneSys Research Institute, Tufts University School of Medicine, Boston, MA, 02135, USA

    Irina Kareva, Kathleen P. Wilkie & Philip Hahnfeldt

Authors
  1. Irina Kareva
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  2. Kathleen P. Wilkie
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  3. Philip Hahnfeldt
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Correspondence to Philip Hahnfeldt .

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Editors and Affiliations

  1. International Prevention Research Institute, Lyon, France

    Alberto d'Onofrio

  2. Istituto di Analisi dei Sistemi ed Informatica "Antonio Ruberti"—CNR, Rome, Italy

    Alberto Gandolfi

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Kareva, I., Wilkie, K.P., Hahnfeldt, P. (2014). The Power of the Tumor Microenvironment: A Systemic Approach for a Systemic Disease. In: d'Onofrio, A., Gandolfi, A. (eds) Mathematical Oncology 2013. Modeling and Simulation in Science, Engineering and Technology. Birkhäuser, New York, NY. https://doi.org/10.1007/978-1-4939-0458-7_6

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