Abstract
The hyalinizing trabecular tumor—or “adenoma,” as it originally was described by Carney in 1987, can mimic medullary and papillary thyroid carcinoma. This unique tumor occurs more commonly in females and over a broad age range (27–72 years; mean, 46 years). These tumors originally were diagnosed as carcinoma, adenoma, paraganglioma, or “indeterminate.” None of the tumors in the original series metastasized during 10 years of follow-up. Additional case reports and small series followed, with a few tumors showing capsular or vascular invasion. These tumors generally are not associated with BRAF or RAS mutations, but RET alterations have been reported. Whether this is sufficient for these tumors to be regarded as variants of papillary thyroid carcinoma (PTC) has been controversial, as RET/PTC rearrangements are not specific for PTC. Some of the hyalinizing trabecular tumors with RET rearrangements were from thyroids that also had PTCs. Also, some have reported RET/PTC rearrangements in Hashimoto thyroiditis, although this is not corroborated by others.
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Erickson, L.A. (2014). Hyalinizing Trabecular Tumor. In: Atlas of Endocrine Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0443-3_6
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DOI: https://doi.org/10.1007/978-1-4939-0443-3_6
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