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Live Donor Transplantation

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Kidney Transplantation

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Abstract

Increasing interest in live donor kidney transplantation has stemmed from the many advantages of live donation including minimizing exposure to dialysis, excellent allograft and donor outcomes, as well as improvement in surgical technique. Recent literature has demonstrated a trend towards an increase in live donor kidney donations over the past 5 decades (Am J Transplant 13(2):390–398, 2013). Balancing this selfless act of donation with the clinical benefit rendered to the recipient requires a complete and thorough evaluation of potential candidates for kidney donation live donation imparts an operation that is not necessary. The evaluation of these donors should ideally minimize morbidity and mortality while at the same time maximize the quality of life for both the recipient and the donor.

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References

  1. Taler SJ, Messersmith EE, Leichtman AB, Gillespie BW, Kew CE, Stegall MD, et al. Demographic, metabolic, and blood pressure characteristics of living kidney donors spanning five decades. Am J Transplant. 2013;13(2):390–8. doi:10.1111/j.1600-6143.2012.04321.x.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  2. Horvat LD, Shariff SZ, Garg AX. Global trends in the rates of living kidney donation. Kidney Int. 2009;75(10):1088–98. doi:10.1038/ki.2009.20.

    Article  PubMed  Google Scholar 

  3. Textor SC, Taler SJ, Driscoll N, Larson TS, Gloor J, Griffin M, et al. Blood pressure and renal function after kidney donation from hypertensive living donors. Transplantation. 2004;78(2):276–82.

    Article  PubMed  Google Scholar 

  4. Segev DL, Muzaale AD, Caffo BS, Mehta SH, Singer AL, Taranto SE, et al. Perioperative mortality and long-term survival following live kidney donation. JAMA. 2010;303(10):959–66. doi:10.1001/jama.2010.237.

    Article  PubMed  CAS  Google Scholar 

  5. Knoll G, Cockfield S, Blydt-Hansen T, Baran D, Kiberd B, Landsberg D, et al. Canadian Society of Transplantation: consensus guidelines on eligibility for kidney transplantation. CMAJ. 2005;173(10):S1–25. doi:10.1503/cmaj.1041588.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Norden G, Lennerling A, Nyberg G. Low absolute glomerular filtration rate in the living kidney donor: a risk factor for graft loss. Transplantation. 2000;70(9):1360–2.

    Article  PubMed  CAS  Google Scholar 

  7. Lin J, Knight EL, Hogan ML, Singh AK. A comparison of prediction equations for estimating glomerular filtration rate in adults without kidney disease. J Am Soc Nephrol. 2003;14(10):2573–80.

    Article  PubMed  Google Scholar 

  8. Lujan PR, Chiurchiu C, Douthat W, de Arteaga J, de la Fuente J, Capra RH, et al. CKD-EPI instead of MDRD for candidates to kidney donation. Transplantation. 2012;94(6):637–41. doi:10.1097/TP.0b013e3182603260.

    Article  PubMed  Google Scholar 

  9. Chung E, Grant AB, Hibberd AD, Sprott P. Why potential live renal donors prefer laparoscopic nephrectomy: a survey of live donor attitudes. BJU Int. 2007;100(6):1344–6. doi:10.1111/j.1464-410X.2007.07126.x.

    Article  PubMed  Google Scholar 

  10. Wilson CH, Sanni A, Rix DA, Soomro NA. Laparoscopic versus open nephrectomy for live kidney donors. Cochrane Database Syst Rev. 2011;(11):CD006124. doi:10.1002/14651858.CD006124.pub2.

  11. Matas AJ, Bartlett ST, Leichtman AB, Delmonico FL. Morbidity and mortality after living kidney donation, 1999–2001: survey of United States transplant centers. Am J Transplant. 2003;3(7):830–4.

    PubMed  Google Scholar 

  12. Fehrman-Ekholm I, Elinder CG, Stenbeck M, Tyden G, Groth CG. Kidney donors live longer. Transplantation. 1997;64(7):976–8.

    Article  PubMed  CAS  Google Scholar 

  13. Okamoto M, Akioka K, Nobori S, Ushigome H, Kozaki K, Kaihara S, et al. Short- and long-term donor outcomes after kidney donation: analysis of 601 cases over a 35-year period at Japanese single center. Transplantation. 2009;87(3):419–23. doi:10.1097/TP.0b013e318192dc95.

    Article  PubMed  Google Scholar 

  14. Ibrahim HN, Foley R, Tan L, Rogers T, Bailey RF, Guo H, et al. Long-term consequences of kidney donation. N Engl J Med. 2009;360(5):459–69. doi:10.1056/NEJMoa0804883.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  15. Mjoen G, Reisaeter A, Hallan S, Line PD, Hartmann A, Midtvedt K, et al. Overall and cardiovascular mortality in Norwegian kidney donors compared to the background population. Nephrol Dial Transplant. 2012;27(1):443–7. doi:10.1093/ndt/gfr303.

    Article  PubMed  Google Scholar 

  16. Garg AX, Meirambayeva A, Huang A, Kim J, Prasad GV, Knoll G, et al. Cardiovascular disease in kidney donors: matched cohort study. BMJ. 2012;344:e1203.

    Article  PubMed Central  PubMed  Google Scholar 

  17. Andersen B, Hansen JB, Jorgensen SJ. Survival after nephrectomy. Scand J Urol Nephrol. 1968;2(2):91–4.

    Article  PubMed  CAS  Google Scholar 

  18. Narkun-Burgess DM, Nolan CR, Norman JE, Page WF, Miller PL, Meyer TW. Forty-five year follow-up after uninephrectomy. Kidney Int. 1993;43(5):1110–5.

    Article  PubMed  CAS  Google Scholar 

  19. Baudoin P, Provoost AP, Molenaar JC. Renal function up to 50 years after unilateral nephrectomy in childhood. Am J Kidney Dis. 1993;21(6):603–11.

    PubMed  CAS  Google Scholar 

  20. Garg AX, Muirhead N, Knoll G, Yang RC, Prasad GV, Thiessen-Philbrook H, et al. Proteinuria and reduced kidney function in living kidney donors: a systematic review, meta-analysis, and meta-regression. Kidney Int. 2006;70(10):1801–10. doi:10.1038/sj.ki.5001819.

    Article  PubMed  CAS  Google Scholar 

  21. Parasuraman R, Venkat KK. Utility of estimated glomerular filtration rate in live kidney donation. Clin J Am Soc Nephrol. 2008;3(6):1608–9. doi:10.2215/cjn.04840908.

    Article  PubMed  Google Scholar 

  22. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351(13):1296–305. doi:10.1056/NEJMoa041031.

    Article  PubMed  CAS  Google Scholar 

  23. Berger JC, Muzaale AD, James N, Hoque M, Wang JM, Montgomery RA, et al. Living kidney donors ages 70 and older: recipient and donor outcomes. Clin J Am Soc Nephrol. 2011;6(12):2887–93. doi:10.2215/cjn.04160511.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Hsu CY, Iribarren C, McCulloch CE, Darbinian J, Go AS. Risk factors for end-stage renal disease: 25-year follow-up. Arch Intern Med. 2009;169(4):342–50. doi:10.1001/archinternmed.2008.605.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Chagnac A, Weinstein T, Korzets A, Ramadan E, Hirsch J, Gafter U. Glomerular hemodynamics in severe obesity. Am J Physiol Renal Physiol. 2000;278(5):F817–22.

    PubMed  CAS  Google Scholar 

  26. Kambham N, Markowitz GS, Valeri AM, Lin J, D’Agati VD. Obesity-related glomerulopathy: an emerging epidemic. Kidney Int. 2001;59(4):1498–509. doi:10.1046/j.1523-1755.2001.0590041498.x.

    Article  PubMed  CAS  Google Scholar 

  27. Heimbach JK, Taler SJ, Prieto M, Cosio FG, Textor SC, Kudva YC, et al. Obesity in living kidney donors: clinical characteristics and outcomes in the era of laparoscopic donor nephrectomy. Am J Transplant. 2005;5(5):1057–64. doi:10.1111/j.1600-6143.2005.00791.x.

    Article  PubMed  Google Scholar 

  28. O’Brien B, Mastoridis S, Crane J, Hakim N, Papalois V. Safety of nephrectomy in morbidly obese donors. Exp Clin Transplant. 2012;10(6):579–85.

    Article  PubMed  Google Scholar 

  29. Young A, Storsley L, Garg AX, Treleaven D, Nguan CY, Cuerden MS, et al. Health outcomes for living kidney donors with isolated medical abnormalities: a systematic review. Am J Transplant. 2008;8(9):1878–90. doi:10.1111/j.1600-6143.2008.02339.x.

    Article  PubMed  CAS  Google Scholar 

  30. Ommen ES, Schroppel B, Kim JY, Gaspard G, Akalin E, de Boccardo G, et al. Routine use of ambulatory blood pressure monitoring in potential living kidney donors. Clin J Am Soc Nephrol. 2007;2(5):1030–6. doi:10.2215/cjn.01240307.

    Article  PubMed  Google Scholar 

  31. Delmonico F. A report of the Amsterdam forum on the care of the live kidney donor: data and medical guidelines. Transplantation. 2005;79(6 Suppl):S53–66.

    PubMed  Google Scholar 

  32. Rule AD, Krambeck AE, Lieske JC. Chronic kidney disease in kidney stone formers. Clin J Am Soc Nephrol. 2011;6(8):2069–75. doi:10.2215/cjn.10651110.

    Article  PubMed Central  PubMed  Google Scholar 

  33. El-Zoghby ZM, Lieske JC, Foley RN, Bergstralh EJ, Li X, Melton III LJ, et al. Urolithiasis and the risk of ESRD. Clin J Am Soc Nephrol. 2012;7(9):1409–15. doi:10.2215/cjn.03210312.

    Article  PubMed Central  PubMed  Google Scholar 

  34. Loo RK, Lieberman SF, Slezak JM, Landa HM, Mariani AJ, Nicolaisen G, et al. Stratifying risk of urinary tract malignant tumors in patients with asymptomatic microscopic hematuria. Mayo Clin Proc. 2013;88(2):129–38. doi:10.1016/j.mayocp.2012.10.004.

    Article  PubMed  Google Scholar 

  35. Vivante A, Afek A, Frenkel-Nir Y, Tzur D, Farfel A, Golan E, et al. Persistent asymptomatic isolated microscopic hematuria in Israeli adolescents and young adults and risk for end-stage renal disease. JAMA. 2011;306(7):729–36. doi:10.1001/jama.2011.1141.

    Article  PubMed  CAS  Google Scholar 

  36. Koushik R, Garvey C, Manivel JC, Matas AJ, Kasiske BL. Persistent, asymptomatic, microscopic hematuria in prospective kidney donors. Transplantation. 2005;80(10):1425–9.

    Article  PubMed  Google Scholar 

  37. Ibrahim HN, Akkina SK, Leister E, Gillingham K, Cordner G, Guo H, et al. Pregnancy outcomes after kidney donation. Am J Transplant. 2009;9(4):825–34.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  38. Flaherty KT, Fuchs CS, Colditz GA, Stampfer MJ, Speizer FE, Willett WC, et al. A prospective study of body mass index, hypertension, and smoking and the risk of renal cell carcinoma (United States). Cancer Causes Control. 2005;16(9):1099–106. doi:10.1007/s10552-005-0349-8.

    Article  PubMed  Google Scholar 

  39. Hunt JD, van der Hel OL, McMillan GP, Boffetta P, Brennan P. Renal cell carcinoma in relation to cigarette smoking: meta-analysis of 24 studies. Int J Cancer. 2005;114(1):101–8. doi:10.1002/ijc.20618.

    Article  PubMed  CAS  Google Scholar 

  40. Ejerblad E, Fored CM, Lindblad P, Fryzek J, Dickman PW, Elinder CG, et al. Association between smoking and chronic renal failure in a nationwide population-based case–control study. J Am Soc Nephrol. 2004;15(8):2178–85. doi:10.1097/01.asn.0000135048.35659.10.

    Article  PubMed  CAS  Google Scholar 

  41. Haroun MK, Jaar BG, Hoffman SC, Comstock GW, Klag MJ, Coresh J. Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland. J Am Soc Nephrol. 2003;14(11):2934–41.

    Article  PubMed  Google Scholar 

  42. Nagasawa Y, Yamamoto R, Rakugi H, Isaka Y. Cigarette smoking and chronic kidney diseases. Hypertens Res. 2012;35(3):261–5. doi:10.1038/hr.2011.205.

    Article  PubMed  Google Scholar 

  43. Orth SR. Effects of smoking on systemic and intrarenal hemodynamics: influence on renal function. J Am Soc Nephrol. 2004;15 Suppl 1:S58–63.

    Article  PubMed  Google Scholar 

  44. Taber DJ, Ashcraft E, Cattanach LA, Baillie GM, Weimert NA, Lin A, et al. No difference between smokers, former smokers, or nonsmokers in the operative outcomes of laparoscopic donor nephrectomies. Surg Laparosc Endosc Percutan Tech. 2009;19(2):153–6. doi:10.1097/SLE.0b013e31819f42f4.

    Article  PubMed  Google Scholar 

  45. Gill JS, Gill J, Barnieh L, Dong J, Rose C, Johnston O, et al. Income of living kidney donors and the income difference between living kidney donors and their recipients in the United States. Am J Transplant. 2012;12(11):3111–8. doi:10.1111/j.1600-6143.2012.04211.x.

    Article  PubMed  CAS  Google Scholar 

  46. Gibney EM, Doshi MD, Hartmann EL, Parikh CR, Garg AX. Health insurance status of US living kidney donors. Clin J Am Soc Nephrol. 2010;5(5):912–6. doi:10.2215/cjn.07121009.

    Article  PubMed Central  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Renal Diseases and Hypertension, University of Minnesota, 717 Delaware Street, S.E., Suite 353, Mail Delivery Code 1932, Minneapolis, MN, 55414, USA

    Scott Reule M.D. & Hassan N. Ibrahim M.D., M.S.

  2. Department of Surgery, University of Minnesota, Minneapolis, MN, USA

    Arthur Matas M.D.

Authors
  1. Scott Reule M.D.
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  2. Arthur Matas M.D.
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  3. Hassan N. Ibrahim M.D., M.S.
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Corresponding author

Correspondence to Hassan N. Ibrahim M.D., M.S. .

Editor information

Editors and Affiliations

  1. Department of Nephrology, University of Maryland, Baltimore, Maryland, USA

    Matthew R. Weir

  2. Department of Medicine, Section of Nephrology, University of Illinois, Berwyn, Illinois, USA

    Edgar V. Lerma

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Reule, S., Matas, A., Ibrahim, H.N. (2014). Live Donor Transplantation. In: Weir, M., Lerma, E. (eds) Kidney Transplantation. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0342-9_8

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  • DOI: https://doi.org/10.1007/978-1-4939-0342-9_8

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