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Biomarkers of Cardiovascular Aging

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Aging and Heart Failure

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Abstract

Aging is a complex phenomenon that exerts a negative impact on the function of different organs including the heart. The life span and the aging state, measured as the decline of functional capacity and stress resistance, are not the same for every individual. Several investigators have attempted to evaluate the relationship between the biological age and chronological age; however, because of the genetic variations, no definitive conclusions can be made. Likewise, various biomarkers based on changes in body function and composition are employed for diagnostic and prognostic measures to understand the biological processes of aging, but no specific marker of aging has yet been identified. Furthermore, risk factors for cardiovascular disease including obesity, hypertension, atherosclerosis, diabetes, myocardial infarction, and cardiac hypertrophy are known to affect the aging process. Since cardiovascular disease is the leading cause of mortality in individuals over 65 years of age, biomarkers such as mediators of oxidative stress, inflammation, and several hormones are considered to be associated with cardiovascular aging. In view of the development of cardiac dysfunction in aging population, there is a need for the identification of possible biomarkers of aging that are independent of comorbidities. Such information may assist in the formulation of new strategies to improve the quality of life and health status of the elderly population.

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Acknowledgements

We thank the St. Boniface Hospital Research Foundation for infrastructural support. N.S.N. was a Visiting Professor from the Government Medical College and Guru Nanak Dev Hospital, Amritsar, India.

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  1. Department of Internal Medicine, Government Medical College and Guru Nanak Dev Hospital, House No. 88, Street 4 Gopal Nagar, Majitha Road, Amritsar, 143001, Punjab, India

    Nirankar S. Neki MD, FRCP, FACP (USA), FAMS

  2. Office of Clinical Research, Asper Clinical Research Institute, St. Boniface Hospital Research, Winnipeg, MB, Canada

    Paramjit S. Tappia PhD

  3. Department of Physiology, Faculty of Medicine, Institute of Cardiovascular Sciences, University of Manitoba, St. Boniface Hospital Research, 351 Tache Avenue, Winnipeg, MB, Canada, R2H 2A6

    Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon)

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  1. Nirankar S. Neki MD, FRCP, FACP (USA), FAMS
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Correspondence to Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) .

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  1. Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta and Hospitals, Edmonton, Alberta, Canada

    Bodh I. Jugdutt

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Neki, N.S., Tappia, P.S., Dhalla, N.S. (2014). Biomarkers of Cardiovascular Aging. In: Jugdutt, B. (eds) Aging and Heart Failure. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0268-2_20

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