Abstract
Mounting evidence suggests that there are a number of important, but poorly understand, interactions between dietary proteins and the human immune system. The usual response of the human immune system to dietary proteins seems to be that of oral tolerance, a phenomenon involving up-regulation of protective gut localized immune mechanisms and down-regulation of potentially harmful systemic immunity to the protein in question. Abrogation of oral tolerance may play an important role in the development of food allergies and food enteropathies. Immune mechanisms underlying oral tolerance are therefore discussed in light of current understanding of such food-related diseases as IgE mediated food allergies and gluten sensitive enteropathy. Possible development of oral vaccines to immune-related diseases like multiple sclerosis and rheumatoid arthritis is also discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ament, M.E. and Rubin, C. E. 1972. Soy protein-another cause of the flat intestinal lesion. Gastroenter. 62: 227.
Anderson J.A. 1990 Food allergy or sensitivity terminology, physiologic bases, and scope of the clinical problem. Ch. 1. In Food Allergies and Adverse Reactions, J.E. Perkin (Ed.), p. 5. Aspen Publishers, Inc., Gaithersburg, MD.
Augustin, A., Kubo, R.T., Sim, G-K., 1989. Resident pulmonary lymphocytes expressing the gamma/delta cell receptor. Nature. 340: 239.
Barbeau, W.E., Novascone, M.A., Elgert, K.D. 1996. Reappraisal of the lectin and immune hypotheses for the etiolgy of celiac disease in light of possible interactions between gliadin peptides and HLA class 11 molecules. Gut, in review.
Barrett, K.E. 1991. Mast cells, basophils and immunoglobulin E. Ch. 2 In Food Allergy: Adverse Reactions to Foods and Food Additives, D.D. Metcalfe, H.A. Sampson and R.A. Simon (Ed.), p. 28–29. Blackwell Scientific Publications, Boston, MA.
Bluestone J.A. and Matis, L.A. 1989. TCR gamma delta cells-minor redundant T cell subset or specialized immune system component? J. Immunol. 142: 1785.
Bosio, L., Barera, G., Mistura, L., Sassi, G., Bianchi, C. 1990. Growth acceleration and final height after treatment for delayed diagnosis of celiac disease. J. Pediatr. Gastroenter. Nutr. 11: 324.
Brandtzaeg, P. 1989. Overview of the mucosal immune system. Curr. Topics Microbiol. Immunol. 146: 13.
Broitman, S.A. and Zamcheck, N. 1980. Nutrition in diseases of the intestines. Ch. 3 IB. hi Modern Nutrition in Health and Disease, 6th ed., RS. Goodhart and M.E. Shils (Ed.), p. 922. Lea & Febiger, Philadelphia, PA.
Brown, J.H., Jardetzky, T. S., Gorga, J.C., Stern, L.J., Urban, R.G., Strominger, J.L., Wiley, D.C. 1993. Three-dimensional structure of the human class 11 histocompatibility antigen HLA-DRI. Nature. 364: 33.
Colyer, J., Farthing M.J.G., Kumar, P.J., Clark, M.L., Ohannesian, A.D., Waldron, N.M. 1986. Reappraisal of the ‘lectin hypothesis’ in the aetiopathogenesis of coeliac disease. Clin Sci. 71: 105.
Cornell, HJ. and Rolles, C. J. 1978. Further evidence of a primary mucosal defect in coeliac disease. Gut 19: 253.
Dellabona, P., Peccoud, J., Kappler, J., Marrack, P., Benoist, C, Mathis, D. 1990. Superantigens interact with MHC class 11 molecules outside of the antigen groove. Cell. 62: 1115.
Emancipator, S.N. and Lamm, M.E. 1988. Oral tolerance as a protective mechanism against hypersensitivity disease. Monogr. Allergy. 24: 244.
Enders, G., Gottwald, T., Brendel, W. 1986. Induction of oral tolerance in rats without Peyer’s patches. Immunol. 58: 311.
Friedman, A., Al-Sabbagh, A., Santos, L.M.B., Fishman-Lobell, J., Polanski, M., Das, M.P., Khoury, S.J., Weiner, H.L. 1994. Oral tolerance: a biologically relevant pathway to generate peripheral tolerance against external and self antigens. Ch. 10 In Chemical Immunology. Mechanisms of Immune Regulation., R.D. Granstein (Ed.), Vol. 58, p. 259. Karger, Basel, Switzerland.
Galliaerde, V., Desvignes, C, Peyron, E., Kaiserlian, D. 1995. Oral tolerance to haptens: intestinal epithelial cells from 2,4-dinitrochlorobenzene-fed mice inhibit hapten-specific T cell activation in vitro. Eur. J. Immunol. 25: 1385.
Garside, P., Steel, M., Liew, F. Y., Mowat, A.M. 1995. CD4+ but not CD8+ T cells are required for the induction of oral tolerance. Internat. Immunol. 7: 501.
Halstensen, T.S., Scott, H., Brandtzaeg, P. 1989. Intraepithelial T cells of the TcR gamma/delta+ CD8-and Vdeltal/jdeltaH-phenotypes are increased in coeliac disease. Scand. J. Immunol. 30: 665.
lyngkaran, N, Abidin, Z., Meng, L.L., Yadav, M. 1982. Egg protein-induced villous atrophy. J. Pediatr. Gastroenter. Nutr. 1: 29.
lyngkaran, N., Yadav, M., Boey, CG., Lam K.L. 1988. Severity and extent of upper small bowel mucosal damage in cow’s milk protein-sensitive enteropathy. J. Pediatr. Gastroenter. Nutr. 7: 667.
Kagnoff, M.F. 1978. effects of antigen-feeding on intestinal and systemic immune responses. 11. Suppression of delayed-type hypersensitivity reactions. J. Immunol. 120: 1509.
Kagnoff, M.F., Austin, R.K., Hubert, J.J., Bernardin, J.E., Karsarda, D.D. 1984. Possible role for a human adenovirus in the pathogenesis of celiac disease. J. Exp. Med. 160: 1544.
Kane, P.M., Holowka, D., Baird, B. 1988. Cross-linking of IgE-receptor complexes by rigid bivalent antigens >200 A in length triggers cellular degranulation. J. Cell Biol 107: 969.
Lider, O., Santos, L.M.B., Lee, C.S. Y., Higgins, P.J., Weiner, H.L. 1989. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basi protein. 11. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes. J. Immunol. 142: 748.
Liener, I.E. 1980. Toxic Constituents Of Plant Foodstuffs, 2nd. ed. Academic Press, New York, NY.
Marsh, M.N. 1992. Gluten, major histocompatibility complex and the small intestine: a molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’) Gastroenterology 102: 330.
Metcalfe, D.D. 1992. The nature and mechanisms of food allergies and related diseases. Food Technol. 46: 136.
Miller A., Lider, O., Weiner, H.L. 1991. Antigen-driven bystander suppression after oral administration of antigens. J.Exp.Med. 174:791.
Mosmann, T.R. and Coffinan, R. L. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol.
Munro, H.N., and Crim, M.C. 1980. The proteins and amino acids. Ch. 3 In Modem Nutrition in Health and Disease, R.S. Goodhart and M.E. Shils (Ed.), p. 82–83. Lea & Febiger, Philadelphia, PA.
Ngan, J. and Kind, L.S. 1978. Suppressor T cells for IgE and IgG in Peyer’s patches of mice made tolerant by the oral administration of ovalbumin. J. Immunol. 120: 861.
O’Farrelly, C. and Gallagher, R.B. 1992. Intestinal gluten sensitivity: snapshots of an unusual auto-immune like disease. Immunol. Today 13: 474.
Perkin, J. E. 1990. Maternal influences on the development of food allergy in the infant. Ch. 5. In Food Allergies and Adverse Reactions, J.E. Perkin (Ed.), p. 89–94, p. 103. Aspen Publishers, Inc., Gaithersburg, MD.
Peters, T.J., Jones, P.E., Wells, G. 1978. Analytical subcellular fractionation of jejunal biopsy specimens: enzyme activities, organelle pathology and response to gluten withdrawal in patients with coeliac disease. Clin. Sci-Mol Med. 55: 285.
Raulet, D.H. 1989. Antigens for gamma/delta T cells. Nature. 339: 342.
Richman, L.K., Graeff, A.S., Yarchoan, R., Strober, W. 1981. Simultaneous induction of antigen-specific IgA helper T cells and IgG suppressor T cells in the murine Peyer’s patches after protein feeding. J. Immunol. 126: 2079.
Sachs, J.A., Awad, I, McCloskey, D., Navarrette, C, Festenstein, H., Elliot, E., Walker-Smith, J.A., Griffiths, C.E., Leonard, J.N., Frye, L. 1986. Different HLA associated gene combinations contribute to susceptibility for coeliac disease and dermatitis herpetiformis. Gut 27: 515.
Sampson, H.A. 1992 Food hypersensitivity: manifestations, diagnosis, and natural history. Food Technol. 46: 141.
Sampson, H.A. and Metcalfe, D.D. 1991. Immediate reactions to foods. Ch. 7. In Food Allergy: Adverse Reactions to Foods and Food Additives, D.D. Metcalfe, H.A. Sampson and R.A. Simon (Ed.), p. 99. Blackwell Scientific Publications, Inc., Boston, MA.
Schild, H., Mavaddat, N, Litzenberger, C, Ehrich, E.W., Davis, M.M., Bluestone, J.A., Matis, L., Draper, R.K., Chien, Y-h. 1994. The nature of the major histocompatibility complex recognition by gamma delta T cells. Cell. 76: 29.
Sloan, A.E. and Powers, M.E. 1986. A perspective on popular perceptions of adverse reactions to foods J. Allergy Clin. Immunol. 78: 127.
Strobel, S. and Ferguson, A. 1984. Immune responses to fed protein antigens in mice. 3. Systemic tolerance or priming is related to age at which antigen is first encountered. J. Pediatr. Res. 18: 588.
Strominger, J.L. 1989. The gamma delta T cell receptor and class 1b MHC-related proteins: enigmatic molecules of immune recognition. Cell 57: 895.
Taylor, S.L. 1992. Chemistry and detection of food allergens. Food Technol. 46: 146.
Trejdosiewicz, L.K., Calabrese, A, Smart, C.J., Oakes, D.J., Howdle, P.D., Crabtree, J.E., Losowsky, M.S., Lancaster, F., Boylston, A.W. 1991 Gamma delta T cell receptorpositive cells of the human gastrointestinal mucosa: occurence and V region gene expression in Heliobacter pylori-associated gastritis, coeliac disease and inflammatory bowel disease. Clin. Exp. Immunol. 84: 440.
Troncone, R. and Auricchio, S. 1991. Gluten sensitive enteropathy (celiac disease). Food Rev. Internat. 7: 205.
Vitoria, J.C., Camarero, C., Sojo, A., Ruiz, A., Rodriguez-Soriano, J. 1982. Enteropathy related to fish, rice, and chicken. Arch. Dis. Child. 57: 44.
Weiner, H.L., Friedman, A., Miller, A., Khoury, S.J., Al-Sabbagh, A., Santos, L., Sayegh, M., Nussenblatt, R.B., Trentham, D.E., Hafler, D.A. 1994. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. 1994. Annu. Rev. Immunol. 12: 809.
Weiser, M.M. and Douglas, A.P. 1976. An alternative mechanism for gluten toxicity in coeliac disease. Lancet 1(7959): 567.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Barbeau, W.E. (1997). Interactions between Dietary Proteins and the Human System: Implications for Oral Tolerance and Food-Related Diseases. In: Damodaran, S. (eds) Food Proteins and Lipids. Advances in Experimental Medicine and Biology, vol 415. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1792-8_14
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1792-8_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1794-2
Online ISBN: 978-1-4899-1792-8
eBook Packages: Springer Book Archive