Abstract
Oligomers containing pendant isocyanate groups and residual double bonds were synthesized from m-isopropenyldimethylbenzylisocyanate, [TMI], and/or 2-isocyanatoethylmethacrylate, [IEM], and methacrylate or vinyl monomers. The compounds were characterized by physico-chemical means. Most of the oligomers are liquids at room temperature, stable in air, have a MW range from 1400 to 2600 and an isocyanate content from 5% to 18%. The compounds, especially those with TMI or IEM and TMI and methacrylate constituents dissolved in suitable solvents yielded stronger, more permanent bonds to glutaraldehyde treated bone than other tissue adhesives. Thermocycling in water for one week between 5°C and 55°C did not decrease adhesion indicating that exposure to water or thermal shock produced no deterioration of the bond. No correlation between bonding efficiency and -NCO content or increase in molecular weight could be established. Tensile adhesion of human dentin joined to composite restorative resins by means of the oligomers was similar to that of the best dental bonding agents. Vinyl monomers containing oligomers are preferable to bond dentin to dental composites. The oligomeric compositions are also excellent soft tissue adhesives. For example, they provide a strong bond between collagenous substrates such as calfskin and cured denture base resins. Subject to their biocompatibility the formulations could find many applications in medicine, dentistry or veterinary science.
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References
F. Leonard, in: “Adhesion in Biological Systems,” R. S. Manly, Ed., Academic Press, New York, 1970, Chapter 11, p. 185.
T. Matsumoto, in: “Adhesion in Biological Systems,” R. S. Manly, Ed., Academic Press, New York, 1970, Chapter 13, p. 209.
G. M. Brauer, J. W. Kumpula, D. J. Termini & K. M. Davidson, J. Biomed. Mater. Res., 13, 593 (1979).
H. Lee, Ed., “Cyanoacrylate Resins — The Instant Adhesives,” Pasadena Technology Press, Pasadena, 1981.
M. C. Harper & M. Ralston, J. Biomed. Mater. Res., 17, 167 (1983).
J. Kilpikari, M. Lapinsuo, P. Tormää, H. Patiää & P. Rokkanen, J. Biomed. Mater. Res., 20, 1095 (1986).
K. A. Galil, I. D. Schofield, G. Z. Wright & L. Ryall, J. Dent. Res., 63, 325 (1984), Abstract No. 1389.
L. E. Arthaud, G. R. Lewellen & W. A. Akers, J. Biomed. Mater. Res., 6, 201 (1972).
R. A. Lehman, G. J. Hayes & F. Leonard, Arch. Surg., 93, 441 (1966).
M. Andersen, M. L. Binderup, P. Kiel, H. Larsen, J. Maxild & S. H. Hansen, Mutat. Res., 102, 378 (1982).
G. C. Eliades, A. A. Caputo & G. J. Vougiouklakis, Dent. Mat., 1, 170 (1985).
D. H. Retief, J. D. Gross, E. L. Bradley & F. R. Denys, Dent. Mat., 2, 72 (1986).
A. Oden & G. Oila, Dent. Mat., 2, 207 (1986).
E. C. Munksgaard & E. Asmussen, J. Dent. Res., 63, 1087 (1984).
E. C. Munksgaard, M. Irie & E. Asmussen, J. Dent. Res., 64, 1409 (1985).
E. Asmussen & E. C. Munksgaard, Eur. Pat. Appl. EP 141, 324, 15 May 1985; U.S. Patent 4,593,054, June 3, 1986.
E. Masuhara, N. Nakabayashi & M. Takeyama (To Mitsui Petrochem. Industries Ltd.), U. S. Patent 4,148,988, April 10, 1979.
R. L. Bowen & E. N. Cobb, J. Am. Dent. Assn., 107, 734 (1983).
R. L. Bowen, U. S. Patent 4,514,527, April 30, 1985; U. S. Patent 4, 521,550, June 4, 1985.
R. L. Bowen, U. S. Patent 4,659,751, April 21, 1987.
V. Naessig, in: “Cyanoacrylate Resins — The Instant Adhesives,” H. Lee, Ed., Pasadena Technology Press, Pasadena, 1981, Chapter 20, p. 143.
R. S. Manly, Ed., “Adhesion in Biological Systems, Part III. Adhesives for Soft Tissue,” Academic Press, New York, 1970, pp. 153–221.
N. A. Peppas & P. A. Buri, J. Control Release, 2, 257 (1985).
M. R. Thomas, Org. Coatings & Polymer Sci. Proc., 46, 506 (1982).
R. W. Dexter, R. Saxon & D. E. Fiori, Polymeric Materials Science & Engineering, 53, 534 (1985).
F. D. Snell & L. S. Ettre, Eds., “Encyclopaedia of Industrial Chemical Analysis,” Interscience, New York, 1974, Vol. 19, p. 272.
ASTM D-2857. “1988 Annual Book of ASTM Standards,” Vol. 08.02, ASTM, Philadelphia, PA, 1988.
F. W. Billmeyer & C. B. DeThan, J. Am. Chem. Soc, 77, 4763 (1955).
W. R. Lacefield, M. C. Reindl & D. H. Retief, J. Prosth. Dent., 53, 194 (1985).
P. E. Cranley, in: “Adhesive Chemistry,” L. H. Lee, Ed., Plenum Publishing Corp. 1984, pp. 765-784.
G. M. Brauer & C. H. Lee, J. Biomed. Mater. Res., 23, 295 (1989).
G. M. Brauer & C. H. Lee, J. Biomed. Mater. Res., (in press).
C. H. Lee & G. M. Brauer, J. Dent. Res., 68, 484 (1989).
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Brauer, G.M., Lee, C.H. (1990). Methacrylate Oligomers with Pendant Isocyanate Groups as Tissue Adhesives. In: Gebelein, C.G., Dunn, R.L. (eds) Progress in Biomedical Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0768-4_7
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DOI: https://doi.org/10.1007/978-1-4899-0768-4_7
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