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Abstract

Dementias were first recognized as a diagnostic issue during the 1800s and have become a major topic only within the last half century. As the population has aged, concern over the dementias has increased because of their higher incidence and the increased sensitivity in medical and mental health circles in recognizing the symptoms of these disorders. Kraepelin (1896) saw dementia as a disease of aging; later versions of his work recognized the writings of Alzheimer (1898) and others who identified the presence of presenile dementias. Over time, there has been increased attention to multiple etiologies and alternative methods of presentation.

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References

  • Alafuzoff, I. (1992). The pathology of dementias: An overview. Ada Neurologica Scandinavica, 139 8–15.

    Article  CAS  Google Scholar 

  • Alafuzoff, I., Ronnberg, A., & Asikainen-Gustafsson, S. (1991). Clinical to histopathological correlation of the diagnosis of dementia. International Psychogeriatrics, 3 69–74.

    Google Scholar 

  • Altman, H., & Normile, H. (1988). What is the nature of the role of the serotonergic nervous system in learning and memory: Prospects for the development of a treatment strategy for senile dementia. Neurobiology of Aging, 9 627–639.

    Article  PubMed  CAS  Google Scholar 

  • Alzheimer, A. (1898). Neuere Arbeiten uber die Dementia senilis und die auf atherimatoser Gefasserk rankung basierended Gehirnkrankheiten. Monatsschrift fuer Psychiatrie und Neurologie, 3 101–115.

    Article  Google Scholar 

  • American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental Disorders (4th ed.). Washington, DC: Author.

    Google Scholar 

  • Anthony, J., LeResche, L., Niaz, U., von Korff, M., & Folstein, M. (1982). Limits of the mini-mental state as a screening test for dementia and delirium among hospital patients. Psychological Medicine, 12 397–408.

    Article  PubMed  CAS  Google Scholar 

  • Artola, A., & Singer, W. (1987). Long term potentiation and NMDS receptors in rat visual cortex. Nature, 330 649–652.

    Article  PubMed  CAS  Google Scholar 

  • Ashford, J. W., Kumar, V., Barringer, M., Becker, M., Bice, J., Ryan, N., & Vicari, S. (1992). Assessing Alzheimer severity with a global clinical scale. International Psychogeriatrics, 1 55–74.

    Article  Google Scholar 

  • Ball, M. (1980). Features of Creutzfeldt-Jakob disease in brains of patients with familial dementia of the Alzheimer’s type. Canadian Journal of Neurological Sciences, 7 51–57.

    PubMed  CAS  Google Scholar 

  • Banfi, S., & Dorigotti, L. (1986). Experimental behavioral studies with oxiracetam on different types of chronic cerebral impairment. Clinical Neuropharmacology 9, 519–526.

    Google Scholar 

  • Beck, E., & Daniel, P. (1987). Neuropathology of transmissible spongiform encephalopathies. In S. Pruisner & M. McKinley (Eds.), Prions: Novel infectious pathogens causing scrapie and Creutzfeldt-Jakob disease. San Diego: Academic.

    Google Scholar 

  • Berg, R., Franzen, M., & Wedding, D. (1994). Screening for brain impairment. New York: Springer.

    Google Scholar 

  • Berman, M. (1990). Severe brain dysfunction: Alcoholic Korsakoff’s syndrome. Alcohol Health and Research, 14 120–129.

    Google Scholar 

  • Biggins, C. A., Boyd, J., Harrop, F., Madeley, P., Mindham, R., Randall, J., & Spokes, E. (1992). A controlled longitudinal study of dementia in Parkinson’s disease. Journal of Neurology, Neuro-surgery, and Psychiatry, 55 566–571.

    Article  CAS  Google Scholar 

  • Bliwise, D., Carroll, J., Lee, K., Nekich, J., & Dement, W. (1993). Sleep and “sundowning” in nursing home patients with dementia. Psychiatry Research, 48 277–292.

    Article  PubMed  CAS  Google Scholar 

  • Bliwise, D. L. (1993). Sleep in normal aging and dementia. Sleep, 16 40–81.

    PubMed  CAS  Google Scholar 

  • Bonte, F. J., Ross, E. D., Chehabi, H. H., & Devous, M. D. (1986). SPECT study of regional cerebral blood flow in Alzheimer’s disease. Journal of Computed Assisted Tomography, 10 579–583.

    Article  CAS  Google Scholar 

  • Bottini, G., Vallar, G., Cappa, S., Monza, G. C., Scarpini, E., Baron, P., Cheldi, A., & Scarlato, G. (1992). Oxiracetam in dementia: A double blind, placebo-controlled study. Ada Neurologica Scandinavica, 86 237–241.

    Article  CAS  Google Scholar 

  • Brandt, J., & Butters, N. (1986). The alcoholic Wernicke-Korsakoff syndrome and its relationship to long term alcohol abuse. In G. Grant & K. Adams (Eds), Neuropsychological assessment of neuropsychiatric disorders. New York: Oxford University Press.

    Google Scholar 

  • Brenner, R., Ulrich, R., Spiker, D., Sclabassi, R., & Reynolds, C. (1986). Computerized EEG spectral analysis in elderly normal, demented, and depressed subjects. Eledroencephalography and Clinical Neurophysiology, 64 483–492.

    Article  CAS  Google Scholar 

  • Breslau, J., Starr, A., Sicotte, N., Higa, J., & Buchsbaum, M. (1989). Topographic EEG changes with normal aging and SDAT. Eledroencephalography and Clinical Neurophysiology, 40 281–289.

    Article  Google Scholar 

  • Brown, P. (1989). Central nervous system amyloidoses: A comparison of Alzheimer’s disease and Creutzfeldt-Jakob disease. Neurology, 39 1103–1105.

    Article  PubMed  CAS  Google Scholar 

  • Burns, A., Philpot, M. P., Costa, D. C., Ell, P. J., & Levy, R. (1989). The investigation of Alzheimer’s disease with single photon emission tomography. Journal of Neurology, Neurosurgery and Psychiatry, 52 248–253.

    Article  CAS  Google Scholar 

  • Carlyle, W., Ancill, R., & Sheldon, L. (1993). Aggression in the demented patient: A double blind study of loxapine versus haloperidol. International Clinical Psychopharmacology, 8 103–108.

    Article  PubMed  CAS  Google Scholar 

  • Chanarin, I., Deacon, R., Lumb, M., & Perry, J. (1989). Cobalaminfolate interrelationships. Blood Review, 3 211–215.

    Article  CAS  Google Scholar 

  • Copeland, J., Kelleher, N., Kellett, J., Gourlay, A., & Gurland, B. (1976). A semistructured clinical interview for the assessment of diagnosis and mental state in the elderly. Psychological Medicine, 6 439–449.

    Article  PubMed  CAS  Google Scholar 

  • Copeland, J. R., Dewey, N., Henderson, A., Kay, D., & Neal, C. (1988). The Geriatric Mental State (GMS) used in the community: Replication studies of the computerized diagnoses AGECAT. Psych ological Medicine, 18 219–223.

    Article  CAS  Google Scholar 

  • Corey-Bloom, J., Galasko, D., Hofstetter, R., Jackson, J., & Thal, L. (1993). Clinical features distinguishing large cohorts with possible AD., probable AD., and mixed dementia. Journal of the American Geriatrics Society, 41 31–37.

    PubMed  CAS  Google Scholar 

  • Cummings, J., & Benson, D. (1992). Dementia. Toronto: Butterwirth-Heinemann.

    Google Scholar 

  • Cutler, N. R., Fakouhi, D., Smith, W. T., Hendrie, H. C., Matsuo, F., Sramek, J. J., & Herting, R. L. (1993). Evaluation of multiple doses of milacemide in the treatment of senile dementia of the Alzheimer’s type. Journal of Geriatric Psychiatry and Neurology, 6 115–119.

    PubMed  CAS  Google Scholar 

  • DeCarli, C., Haxby, J., Gillette, J., Teichberg, D., Rapoport, S., & Schapiro, M. (1992). Longitudinal changes in lateral ventricular volume in patients with dementia of the Alzheimer type. Neurology, 42 2029–2036.

    Article  PubMed  CAS  Google Scholar 

  • Eberling, J. L., Jagust, W. J., Reed, B. R., & Baker, M. G. (1992). Reduced temporal lobe blood flow in Alzheimer’s disease. Neurobiology of Aging, 13 483–491.

    Article  PubMed  CAS  Google Scholar 

  • Edwards, A. J. (1993). Dementia. New York: Plenum Press.

    Book  Google Scholar 

  • Evenhuis, H. M. (1992). Evaluation of a screening instrument for dementia in aging mentally retarded persons. Journal of Intellectual Disability Research, 36 337–347.

    Article  PubMed  Google Scholar 

  • Fields, S., Fulop, G., Sachs, C., Strain, J., & Fillit, H. (1992). Usefulness of the neurobehavioral cognitive status examination in the hospitalized elderly. International Psychogeriatrics, 4 93–102.

    Article  PubMed  CAS  Google Scholar 

  • Fischhof, P., Saletu, B., Ruther, E., Litschauer, G., Moslinger-Gehmayr, R., & Herrmann, W. (1992). Therapeutic efficacy of pyritinol in patients with senile dementia of the Alzheimer type (SDAT) and multi-infarct dementia (MID). Neuropsychobiology, 26 65–70.

    Article  PubMed  CAS  Google Scholar 

  • Folstein, M., Folstein, S., & McHugh, P. (1975). “Mini-mental state”: A practical method for grading the cognitive states of patients for the clinician. Journal of Psychiatric Research, 12 189–198.

    Article  PubMed  CAS  Google Scholar 

  • Fratiglioni, L., Grut, M., Forsell, Y., Viitanen, M., & Winblad, B. (1992). Clinical diagnosis of Alzheimer’s disease and other dementias in a population survey. Archives of Neurology, 49 927–932.

    Article  PubMed  CAS  Google Scholar 

  • Galasko, D., Klauber, M., Hofstetter, R., Salmon, D., Lasker, B., & Thal, L. (1990). The MMSE in the early diagnosis of Alzheimer’s disease. Archives of Neurology, 47 49–52.

    Article  PubMed  CAS  Google Scholar 

  • Giurgea, C. (1972). Vers une pharmacologie de l’activité integrative du cerveau: Tentative du concept nootrope en psychopharmacologie. Actual Pharmacology, 25 115–156.

    CAS  Google Scholar 

  • Golden, C., Osmon, D., Moses, J., & Berg, R. (1981). Interpretation of the Halstead-Reitan Neuropsychological Battery. New York: Harcourt Brace Jovanovich.

    Google Scholar 

  • Golden, C., Zillmer, E., & Spiers, M. (1992). Neuropsychological assessment and intervention. Springfield, IL: Thomas.

    Google Scholar 

  • Goodwin, J. S., Goodwin, J. M., & Garry, P. J. (1983). Association between nutritional status and cognitive functioning in a healthy elderly population. Journal of the American Medical Association, 249 2917–2921.

    Article  PubMed  CAS  Google Scholar 

  • Gottfries, C. (1991). Classifying organic mental disorders and dementia—A review of historical perspectives. International Psychogeriatrics, 3 9–17.

    Google Scholar 

  • Gottfries, C., Adolfsson, R., & Aquilonius, S. (1983). Biochemical changes in dementia disorders of the Alzheimer type (AD/SDAT). Neurobiology of Aging, 4 261–271.

    Article  PubMed  CAS  Google Scholar 

  • Günther, W., Giunta, R., Klages, U., Haag, C., Steinberg, R., Satzger, W., Jonitz, L., & Engel, R. (1993). Findings of electroencephalographic brain mapping in mild to moderate dementia of the Alzheimer type during resting, motor, and music-perception conditions. Psychiatry Research: Neuroimaging, 50 163–176.

    Article  PubMed  Google Scholar 

  • Gurland, B., Kuriansky, J., Sharpe, L., Simon, R., & Stiller, P. (1977). The comprehensive assessment and referral evaluation (CARE). International Journal of Aging and Human Development, 8 9–42.

    Article  PubMed  Google Scholar 

  • Gustafson, L. (1992). Clinical classification of dementia conditions. Acta Neurologica Scandinav-ica, 139 16–20.

    Article  CAS  Google Scholar 

  • Herrmann, W., & Stephan, K. (1992). Moving from the question of efficacy to the question of therapeutic relevance: An exploratory reanalysis of a controlled clinical study of 130 inpatients with dementia syndrome taking piracetam. International Psychogeriatrics, 4 25–44.

    Article  PubMed  CAS  Google Scholar 

  • Holttum, J., & Gershon, S. (1992). The cholinergic model of dementia, Alzheimer type: Progression from the unitary transmitter concept. Dementia, 3 174–185.

    Google Scholar 

  • Israel, J., Kozarevic, N., & Sarorius, N. (1984). Source book of geriatric assessment. Basel, Switzerland: Karger.

    Google Scholar 

  • Jacobson, R., Acker, C., & Lishman, W. (1990). Patterns of neuropsychological deficit in alcoholic Korsakoff’s syndrome. Psychological Medicines, 20 321–334.

    Article  CAS  Google Scholar 

  • Jarvik, L. F. (1992). Possible biological basis for a major memory disorder. In J. Morley, R. Coe, R. Strong, & G. Grossbergs (Eds.), Memory function and age related disorders. New York: Springer.

    Google Scholar 

  • Johnson, J. W., & Asher, P. (1987). Gylcine potentiates the NMDS response in cultured mouse brain neurons. Nature, 325 31–35.

    Article  Google Scholar 

  • Jones, H., Hedley-White, T., & Friedberg, S. (1985). Ataxic Creutzfeldt-Jakob disease: Diagnostic techniques and neuropathological observations in early disease. Neurology, 35 254–357.

    Article  PubMed  Google Scholar 

  • Jung, R., & Solomon, K. (1993). Clinical practice and psychiatric manifestations of Pick’s disease. International Psychogeriatrics, 5 187–202.

    Article  PubMed  CAS  Google Scholar 

  • Kay, D., Henderson, A., Scott, R., Wilson, J., Rickwood, D., & Grayson, D. (1985). Depression and dementia among the elderly living in the Hobart community. Psychological Medicine, 15 771–788.

    Article  PubMed  CAS  Google Scholar 

  • Kraepelin, E. (1896). Psychiatrie: Ein Lehrbuch für Studierende und Aerzte. Leipzig, Germany: Verlag von Johann Ambrosius Bath.

    Google Scholar 

  • Kuhn, F. J., Schingnitz, G., Lehr, E., Montagna, E., Hansen, H. D., & Giachetti, A. (1988). Pharmacology of WEB-1881-F, a central cholinergic agent, which enhances cognition and cerebral metabolism. Archives of Internal Pharmacodynamic Therapy, 292 13–34.

    CAS  Google Scholar 

  • Kumar, A., Schapiro, M. B., Grady, C., Haxby, J. V., Wagner, E., Salerno, J. A., Friedland, R. P., & Rapoport, S. (1991). High-resolution PET studies in Alzheimer’s disease. Neuropsychophar-macology, 4 35–46.

    CAS  Google Scholar 

  • Kurz, A., Haupt, M., Pollmann, S., & Romero, B. (1992). Alzheimer’s disease: Is there evidence of phenomenological subtypes? Observations from a longitudinal study. Dementia, 3 320–327.

    Google Scholar 

  • Lamberty, G. J., & Bieliauskas, L. A. (1993). Distinguishing between depression and dementia in the elderly: A review of neuropsychological findings. Archives of Clinical Neuropsychology, 8 149–170.

    PubMed  CAS  Google Scholar 

  • Levitt, A. J., & Karlinsky, H. (1992). Folate, vitamin B12, and cognitive impairment in patients with Alzheimer’s disease. Acta Psychiatrica Scandinavica, 86 301–305.

    Article  PubMed  CAS  Google Scholar 

  • Marsden, C., & Fahn, S. (1987). Movement disorders II. London: Butterworths.

    Google Scholar 

  • Mendez, M., Selwood, A., Mastri, A., & Frey, W. (1993). Pick’s disease versus Alzheimer’s disease: A comparison of clinical characteristics. Neurology, 43 289–292.

    Article  PubMed  CAS  Google Scholar 

  • Mielke, R., Herholz, K., Grond, M., Kessler, J., & Heiss, W. (1992). Severity of vascular dementia is related to volume of metabolically impaired tissue. Archives of Neurology, 49 909–913.

    Article  PubMed  CAS  Google Scholar 

  • Miller, B., Cummings, J., Villanueva-Meyer, J., Boone, K., Mehringer, C., Lesser, I., & Mena, I. (1991). Frontal lobe degeneration: Clinical, neuropsychological, and SPECT characteristics. Neurology 41, 1374–1382.

    Article  PubMed  CAS  Google Scholar 

  • Miyauchi, T., Hagimoto, H., Ishii, M., Endo, S., Tanaka, K., Kajiwara, S., Endo, M., Kajiwara, A., & Kosaka, K. (1994). Quantitative EEG in patients with presenile dementia of the Alzheimer type. Ada Neurologica Scandinavica, 89 56–64.

    Article  CAS  Google Scholar 

  • Mondadori, C., & Classen, W. (1984). Effect of oxiracetam on the performance of aged rates in a one way active avoidance situation. Clinical Neuropharmacology, 1984 770–771.

    Google Scholar 

  • Nissen, T., Mellgren, S., & Selseth, B. (1989). Démens evaluert med MMSE. Tidsskrift for den Norske Laegeforening, 109 1158–1162.

    PubMed  CAS  Google Scholar 

  • Oberholzer, A., Hendriksen, C., Monsch, A., Hieierli, B., & Stahelin, H. (1992). Safety and effectiveness of low-dose clozapine in psychogeriatric patients: A preliminary study. International Psychogeriatrics, 4 187–195.

    Article  PubMed  CAS  Google Scholar 

  • Ohno, M., Yamamoto, T., Kitajima, I., & Ueki, S. (1990). WEB 1881 F ameliorates impairment of working memory induced by scopolamine and cerebral ischemia in the three panel runway task. Japanese Journal of Pharmacology, 54 53–60.

    Article  PubMed  CAS  Google Scholar 

  • Olafsson, K., Jorgensen, S., Jensen, H., Bille, A., Amp, P., & Andersen, J. (1992). Fluvoxamine in the treatment of demented patients: A double blind, placebo controlled study. Acta Psychiatrica Scandinavica, 85 453–456.

    Article  PubMed  CAS  Google Scholar 

  • Onofri, M., Gambi, D., Del Re, M., Fulgente, T., Bazzano, S., Colamartino, P., & Malatesta, G. (1991). Mapping of event related potentials to auditory and visual odd ball paradigms in patients affected by different forms of dementia. European Neurology, 31 259–269.

    Article  Google Scholar 

  • Overall, J. E., & Schaltenbrand, R. (1992). The SKT neuropsychological test battery. Journal of Geriatric Psychiatry and Neurology, 5 220–227.

    PubMed  CAS  Google Scholar 

  • Parsons, O., & Nixon, S. (1993). Neurobehavioral sequelae of alcoholism. Neurologic Clinics, 11 205–218.

    PubMed  CAS  Google Scholar 

  • Pinner, E., & Rich, C. (1988). Effects of trazodone on aggressive behavior in seven patients with organic mental disorder. American Journal of Psychiatry, 145 1295–1296.

    PubMed  CAS  Google Scholar 

  • Powell, A. L., Mezrich, R. S., Coyne, A. C., Loesberg, A., & Keller, I. (1993). Convex third ventricle: A possible sign for dementia using MRI. Journal of Geriatric Psychiatry and Neurology, 217-221.

    Google Scholar 

  • Rapp, M. S., Flint, A., Herrmann, N., & Proulx, G. (1992). Behavioral disturbances in the demented elderly: Phenomenology, pharmacotherapy, and behavioural management. Canadian Journal of Psychiatry, 37 651–657.

    CAS  Google Scholar 

  • Roman, G., Tatemichi, T., Erkinguntti, T., Cummings, J., Masdeu, J., Garcia, J., Amaducci, L., Orgogozo, J., Brun, A., Hofman, A., Moody, D., O’Brien, M., Yamaguchi, T., Grafman, J., Drayer, B., Bennet, D., Fisher, M., Ogata, J., Kokmen, E., Bermejo, E., Wolf, P., Gorelick, P., Bick, K., Pageau, A., Bell, M., DeCarli, C., Culebras, A., Korczyn, Z., Bogousslavsky, J., Hartmann, A., & Scheinberg, P. (1993). Vascular dementia: Diagnostic criteria for research studies. Neurology, 43 250–260.

    Article  PubMed  CAS  Google Scholar 

  • Rosen, J., Mulsant, B., & Wright, B. (1992). Agitation in severely demented patients. Annals of Clinical Psychiatry, 4 207–215.

    Article  Google Scholar 

  • Roth, M., Tym, E., Mountjoy, C., Huppert, F., & Hendrie, H. (1986). CAMDE: A standardized instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. British Journal of Psychiatry, 149 698–709.

    Article  PubMed  CAS  Google Scholar 

  • Sabe, L., Jason, L., Juejati, M., Leiguarda, R., & Starkstein, S. (1993). Sensitivity and specificity of the mini-mental state exam in the diagnosis of dementia. Behavioural Neurology, 6 207–210.

    Google Scholar 

  • Saletu, B., & Anderer, P. (1988). EEG Mapping in der psychiatrischen diagnose und thera-pieforschung. In B. Saletu (Ed.), Biologische Psychiatrie. New York: Springer-Verlag.

    Google Scholar 

  • Saletu, B., Anderer, P., Fischhof, P., Lorenz, H., Barousch, R., & Bohmer, F. (1992). EEG mapping and psychopharmacological studies with deribufylline in SDAT and MID. Biological Psychiatry, 32 668–681.

    Article  PubMed  CAS  Google Scholar 

  • Sawada, H., Udaka, F., Kameyama, M., Seriu, N., Nishinaka, K., Shindou, K., Kodama, M., Nishitani, N., & Okumiya, K. (1992). SPECT findings in Parkinson’s disease associated with dementia. Journal of Neurology, Neurosurgery, and Psychiatry, 55 960–963.

    Article  PubMed  CAS  Google Scholar 

  • Schneider, L., & Sobin, P. (1992). Non-neuroleptic treatment of behavioral symptoms and agitation in Alzheimer’s disease and other dementias. Psychopharmacology Bulletin, 28 71–79.

    PubMed  CAS  Google Scholar 

  • Schneider, L., Pollock, V., & Lyness, S. (1990). A metaanalysis of controlled trials of neuroleptic treatment in dementia. Journal of the American Geriatric Association, 38 553–563.

    CAS  Google Scholar 

  • Shorvon, S. D., Carney, M. W. P., Chanarin, I., & Reynolds, E. H. (1980). The neuropsychiatry of megaloblastic anaemia. British Journal of Medicine, 281 1036–1038.

    Article  CAS  Google Scholar 

  • Shulman, R. (1967). Vitamin B12 deficiency and psychiatric illness. British Journal of Psychiatry, 113 252–256.

    Article  PubMed  CAS  Google Scholar 

  • Simpson, S., & Foster, D. (1986). Improvement in organically disturbed behavior with trazodone treatment. Journal of Clinical Psychiatry, 47 191–193.

    PubMed  CAS  Google Scholar 

  • Skoog, I., Nilsson, L., Palmertz, B., Andreasson, L., & Svanborg, A. (1993). A population based study of dementia in 85 year olds. New England Journal of Medicine, 328 153–158.

    Article  PubMed  CAS  Google Scholar 

  • Sneath, P., Chanarin, I., Hodkinson, H. M., McPherson, C. K., & Reynolds, E. H. (1973). Folate status in a geriatric population and its relation to dementia. Age and Aging, 2 177–182.

    Article  CAS  Google Scholar 

  • Spignoli, G., Pedata, F., Giovanelli, L., Banfi, S., Moroni, F., & Pepeu, G. (1986). Effect of oxiracetam and piracetam on central cholinergic mechanisms and active avoidance acquisition. Clinical Neuropharmacology, 9 S39–S47.

    PubMed  CAS  Google Scholar 

  • Strathmann, G. C. (1988). Possible neurotransmitter basis of behavioral changes in Alzheimer’s disease. Annals of Neurology, 23 616–620.

    Article  Google Scholar 

  • Swaab, D. F. (1991). Brain aging and Alzheimer’s disease, “wear and tear” versus “use it or lose it.” Neurobiology of Aging, 12 317–324.

    Article  PubMed  CAS  Google Scholar 

  • Urakami, K., Shimomura, T., Ohshima, T., Okada, A., Adachi, Y., Takahashi, K., Asakura, M., & Matsumura, R. (1993). Clinical effect of WEB 1881 (Nebracetam Fumurate) on patients with dementia of the Alzheimer type and study of its clinical pharmacology. Clinical Neuro-phamacology, 16 347–358.

    CAS  Google Scholar 

  • Van der Cammen, T., Van Harskamp, F., Stronks, D., Passchier, J., & Schudel, W. (1992). Value of the mini-mental status examination and informants’ data for the detection of dementia in geriatric outpatients. Psychological Reports, 71 1003–1009.

    PubMed  Google Scholar 

  • Zappoli, R., Ametoli, G., Paganini, M., Battaglia, A., Novellini, R., & Pamparana, F. (1991). Topographic bit-mapped event-related neurocognitive potentials and clinical status in patients with primary presenile mental decline chronically treated with nicergoline. Current Therapeutic Research, 49 1078–1097.

    Google Scholar 

  • Zaudig, M. (1992). A new systematic method of measurement and diagnosis of “mild cognitive impairment” and dementia according to ICD-10 and DSM-III-R criteria. International Psy-chogeriatrics, 4 203–239.

    Article  Google Scholar 

  • Zaudig, M., Mittelhammer, J., Hiller, W., Pauls, A., & Thora, C. (1991). SIDAM-A structured interview for the diagnosis of dementia of the Alzheimer type multi-infarct dementia, and dementias of other etiology according to ICD-10 and DSM-III-R. Psychological Medicine, 21 225–236.

    Article  PubMed  CAS  Google Scholar 

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Golden, C.J., Chronopolous, A. (1998). Dementia. In: Hersen, M., Van Hasselt, V.B. (eds) Handbook of Clinical Geropsychology. The Springer Series in Adult Development and Aging. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0130-9_7

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