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Requirement for Macrophages in Primary and Secondary Humoral Responses

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Immunology

Abstract

The involvement of macrophages in the initiation and regulation of humoral and cellular immune responses and the functions of macrophages as nonspecific effector cells of the immune system have become better understood during the past 20 years. This began with the demonstration that antigens localized and were retained in lymphoid tissues in areas rich in macrophages and dendritic cells. Further, evidence was presented that macrophages, after ingestion and degradation of antigen, presented antigenic fragments which were highly immunogenic and critical for initiation of immune responses by lymphocytes. Later, several investigators demonstrated that antigen associated with macrophages was the important immunogen both in vivo and in vitro. The development of tissue culture systems capable of supporting development of both antibody and cellular immune responses and procedures to separate macrophages from complex cell mixtures has permitted more detailed and definitive investigations of functions of macrophages in immune responses.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, The Jewish Hospital of St. Louis, and Department of Pathology and of Microbiology and Immunology, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Carl W. Pierce

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  1. Carl W. Pierce
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Editors and Affiliations

  1. Georgetown University School of Medicine, Washington, D.C., USA

    Joseph A. Bellanti

  2. Georgetown University Schools of Medicine and Dentistry, Washington, D.C., USA

    Herbert B. Herscowitz

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Pierce, C.W. (1984). Requirement for Macrophages in Primary and Secondary Humoral Responses. In: Bellanti, J.A., Herscowitz, H.B. (eds) Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6784-1_10

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  • DOI: https://doi.org/10.1007/978-1-4757-6784-1_10

  • Publisher Name: Springer, Boston, MA

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