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Flavonoids and Gene Expression in Mammalian Cells

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Flavonoids in Cell Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 505))

Abstract

Flavonoids are found to be widely present in the plant kingdom and possess diverse biological activities. The focus of this review is on their regulation of gene expression in mammalian cells. Although a direct DNA-flavonoid interaction could be demonstrated (Ahmed et al., 1994; Strick et al., 2000), this reaction lacks the DNA sequence specificity that is needed for gene regulation. Indeed, no particular gene regulation was reported as a consequence of the DNA-flavonoid interaction. Instead, flavonoids appear to regulate gene expression through interactions with protein transcription factors as described below. Most of the studies in this area examined dietary flavonoids. Some medicinal and synthetic flavonoid-like compounds have also been developed for potential pharmaceutical applications.

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  1. Department of Physical Therapy, Exercise and Nutrition Sciences, Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY, 14214, USA

    Shiu-Ming Kuo

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  1. Shiu-Ming Kuo
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  1. USDA Citrus and Subtropical Products Laboratory, Winter Haven, Florida, USA

    Béla S. Buslig  & John A. Manthey  & 

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Kuo, SM. (2002). Flavonoids and Gene Expression in Mammalian Cells. In: Buslig, B.S., Manthey, J.A. (eds) Flavonoids in Cell Function. Advances in Experimental Medicine and Biology, vol 505. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5235-9_18

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  • DOI: https://doi.org/10.1007/978-1-4757-5235-9_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3383-6

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