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Myocardial Energy Metabolism of Congestive and Hypertrophic Cardiomyopathy in Man

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Advances in Myocardiology

Abstract

A key enzyme of glycolysis (pyruvate kinase) and main enzymes of the electron transport system (NADH cytochrome c reductase, succinic cytochrome c reductase, and cytochrome c oxidase) were measured in left ventricular biopsy specimens from six hypertrophic (HCM) and six congestive (CCM) cardiomyopathy. Pyruvate kinase was 104.0 and 45.0 mU/ mg protein in HCM and CCM, respectively. NADH cytochrome c reductase, succinic cytochrome c reductase, and cytochrome c oxidase were 146.0, 9.9, and 775.0 mU/mg protein in HCM and 87.4, 5.2, and 502.0 mU/mg protein in CCM, respectively. From these data, it is evident that glycolysis and enzyme activities of the electron transport system are increased in HCM and decreased in CCM. Cardiac function reflects the state of these energy metabolism pathways in the myocardium. The changing energy metabolism in the right ventricle of the emphysema hamster seems to support this concept.

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References

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Author information

Authors and Affiliations

  1. Department of Radiology, Nihon University School of Medicine, Tokyo, 173, Japan

    H. Abe

  2. Department of Internal Medicine, Josai Dental University, Saitama, Japan

    T. Yamada, K. Miyata & A. Yoshida

  3. Cardiovascular Diagnostic Laboratory Center, Toho University School of Medicine, Tokyo, Japan

    Y. Yabe

Authors
  1. H. Abe
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  2. T. Yamada
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  3. K. Miyata
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  4. A. Yoshida
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  5. Y. Yabe
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Editor information

Editors and Affiliations

  1. Cardiology Research Center, Academy of Medical Sciences, Moscow, USSR

    E. Chazov M.D.

  2. Institute of Pathology, McGill University, Montreal, Quebec, Canada

    G. Rona M.D.

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© 1983 Springer Science+Business Media New York

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Abe, H., Yamada, T., Miyata, K., Yoshida, A., Yabe, Y. (1983). Myocardial Energy Metabolism of Congestive and Hypertrophic Cardiomyopathy in Man. In: Chazov, E., Saks, V., Rona, G. (eds) Advances in Myocardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4441-5_8

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  • DOI: https://doi.org/10.1007/978-1-4757-4441-5_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4443-9

  • Online ISBN: 978-1-4757-4441-5

  • eBook Packages: Springer Book Archive

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