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Force-Velocity-Length Relationship during Cardiac Hypertrophy

Time Course of Activation

  • Chapter
Advances in Myocardiology

Abstract

Basic mechanical properties observed during cardiac hypertrophy were studied in left ventricular rat papillary muscles after exposure to chronic pressure and/or volume overloading. It is always possible, during such overloading conditions, to define the level of contractility in terms of a force-velocity-length (F-V-L) relationship regardless of time and initial length. Thus, during a determined period of the contraction phase and for a given total load, shortening velocity remained an univocal time-invariant function of shortening length, involving a time-independent maximum intensity of activation. The onset of this precise phase was reached relatively soon after stimulus. The time-independent F-V-L relation was observed both in controls and in hypertrophied heart muscles, whatever the degree and the type of induced hypertrophy, and even during the latest phases of congestive heart failure.

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Author information

Authors and Affiliations

  1. I.N.S.E.R.M. U2, Hôpital Léon Bernard, 94450, Limeil-Brévannes, France

    Y. Lecarpentier, P. Gastineau & P. Y. Hatt

  2. E.N.S.T.A., Ecole Polytechnique, 91120, Palaiseau, France

    J. L. Martin

Authors
  1. Y. Lecarpentier
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  2. P. Gastineau
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  3. P. Y. Hatt
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  4. J. L. Martin
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Editor information

Editors and Affiliations

  1. Cardiology Research Center, Academy of Medical Sciences, Moscow, USSR

    E. Chazov M.D.

  2. Institute of Pathology, McGill University, Montreal, Quebec, Canada

    G. Rona M.D.

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© 1983 Springer Science+Business Media New York

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Lecarpentier, Y., Gastineau, P., Hatt, P.Y., Martin, J.L. (1983). Force-Velocity-Length Relationship during Cardiac Hypertrophy. In: Chazov, E., Saks, V., Rona, G. (eds) Advances in Myocardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4441-5_6

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  • DOI: https://doi.org/10.1007/978-1-4757-4441-5_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4443-9

  • Online ISBN: 978-1-4757-4441-5

  • eBook Packages: Springer Book Archive

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