Abstract
Under conditions of experimental cardiac overload and hypertrophy in rats, a di-goxinlike immunoreactivity appears in their serum which is correlated with cardiac growth. It is hypothesized that this is caused by the presence of an endogenous cardiotropic factor displaying cross immunoreactivity with digoxin. Additional evidence of the existence of the putative cardiotropic factor is provided by the finding that the sera of rats with cardiac overload displaying digoxinlike immunoreactivity stimulate the multiplication of rat cardiac myocytes in the tissue culture. This factor may be an adrenal steroid different from corticosterone and aldosterone. The name endocardin or endocardiotonin for this substance is suggested.
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References
Beznak, M. 1964. Hormonal influences in regulation of cardiac performance. Cire. Res. 14–15(Suppl. 2): 141–152.
Caldarera, C. M., Guarnieri, C., Clo, C., Ferrari, R., and Casti, A. 1979. Early biochemical events of myocardial hypertrophy In: P. Padieu and J.-P. Didier (eds.), 3eme Reunion de la Section Europeenne De l’ISHR, pp. 125–138. Faculté de Medecine de Dijon, Dijon.
Drost, R. H., Plomp, T. A., Teunissen, A. J., Maas, A. H. J., and Maes, R. A. A. 1977. A comparative study of the homogenous enzyme immunoassay (EMIT) and two radioimmunoassays (RIA’s) for digoxin. Clin. Chim. Acta 79:557–567.
Duncan, D. B. 1955. Multiple range and multiple F tests. Biometrics 11:1–42.
Fízel, A., and Fízelová, A. 1972. Participation of catecholamines and cortical hormones in the myocardial metabolic adaptation to mechanical overload of the heart. In: E. Bajusz, and G. Rona (eds.) Myocardiology Vol. 1, pp. 814–827. Urban & Schwarzenberg, Munich, Berlin, Vienna.
Kölbel, F. 1978. Biochemické mechanismy vzniku hypertrofie levé srdeční komory [Biochemical mechanisms of the induction of left ventricular hypertrophy.] Cesk. Fysiol. 27:523–530.
Kölbel, F., Kapitola, J., Schreiberová, O., and Kölblová, V. 1970. Influence of adrenalectomy on the effects of isoproterenol in the rat. Physiol. Bohemoslov. 19:281–289.
Kölbel, F., Kapitola, J., Šonka, J., and Schreiberová, O. 1972. Hormonal and humoral modulation of the effects of isoproterenol. In: P.-Y. Hatt (ed.), Les Surcharges Cardiaques, pp. 39–47. INSERM, Paris.
Kölbel, F., Mommaerts, W. F. H. M., Kölblová, V., and Vančura, P. 1970. Cardiac muscle and liver ribosomes of the rat: The influence of laparotomy and laparotomy combined with adrenalectomy. Experientia 26:361–362.
Limas, C. J., and Chan-Stier, C. 1978. Myocardial chromatin activation in experimental hyperthyroidism in rats. Circ. Shock 42:311–322.
Mattingly, D. 1962. A simple fluorometric method for the estimation of free 11-hydroxy-corticoids in human plasma. J. Clin. Pathol. 15:374–385.
Morris, B. J., Davis, J. O., Zatzman, M. L., and Williams, G. M. 1977. The renin angiotensin aldosterone system in rabbits with congestive heart failure produced by aortic constriction. Circ. Res. 40:275–286.
Rubenstein, K. E., Schneider, R. S., and Ullman, E. F. 1972. Biochem. Biophys. Res. Commun. 47:846–851.
Schreiber, V., Kölbel, F., Horký, K., and Štěpán, J. 1980. Hormonální faktory v růstových reakcích srdečního svalu [Hormonal factors in growth reactions of heart muscle] Cesk. Fysiol. 29:489–500.
Schreiber, V., Kölbel, F., and Štěpán, J. 1980. Zdánlivá (?) imunoreaktivita digoxinu v séru krys se srde&čním přetížením. K otázce endogenního kardiotonika (endokardinu) [Apparent (?) immunoreactivity of digoxin in the sera of rats with cardiac overload—on the problem of endogenous cardiotonic (endocardin)]. Cas. Lek. Cesk. 119:768–770.
Schreiber, V., Kölbel, F., Štěpán, J., Gregorová, I., and Přibyl, T. 1980. Digoxin-like immunoreactivity in the serum of rats with cardiac overload. J. Mol. Cell. Cardiol. 75:107–110.
Schreiber, V., Štěpán, J., Gregorová, I., Kölbel, F., Přibyl, T., Jahodová, J., and Janovská, J. 1980. Digoxinu podobná imunoreaktivita v seru hyperthyreoidních krys se srdeční hy-pertrofií není způsobena aldosteronem [Digoxinlike immunoreactivity in the serum of hy-perthyroid rats with cardiac hypertrophy is not caused by aldosterone]. Sb. Lek. 82:305–308.
Schreiber, V., Štěpán, J., Kölbel, F., Přibyl, T., Jahodová, J., and Kubová, V. 1980. Failure of the aldosterone antagonist spironolactone to inhibit myocardial hypertrophy produced by experimental hyperthyroidism and accompanied by “apparent” digoxin immunoreactivity in the blood. Physiol. Bohemoslov. 29:577–579.
Sharma, V. K., and Banerjee, S. P. 1978. Specific 3H-ouabain binding to rat heart and skeletal muscle: Effects of thyroidectomy. Mol. Pharmacol. 14:122–129.
Turto, H., and Lindy, S. 1973. Digitoxin treatment and experimental cardiac hypertrophy in the rat. Cardiovasc. Res. 7:482–487.
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Kölbel, F., Schreiber, V., Štěpán, J., Přibyl, T., Gregorová, I. (1983). Reflections on What Makes the Heart Grow. In: Chazov, E., Saks, V., Rona, G. (eds) Advances in Myocardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4441-5_5
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DOI: https://doi.org/10.1007/978-1-4757-4441-5_5
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