Abstract
Administration of lithium carbonate to normal subjects and psychiatric patients causes increased production of granulocytes (Rothstein et al., 1978; Stein et al., 1978b). The administration of lithium carbonate to patients receiving cancer chemotherapy can attenuate neutropenia when regimens of moderate myelotoxicity are employed (Stein et al., 1977; Greco and Brereton, 1977). We have previously reported in preliminary form (Stein et al., 1978a) that lithium can limit the duration of the severe neutropenia associated with chemotherapy of acute myelogenous leukemia (AML), a situation in which effective therapy is associated with severe neutropenia. This report presents an update of that clinical trial.
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Alavi, J.B., Root, R.K., Djerassi, I., Evans, A.E., Gluckman, S.J., Macgregor, R.R., Guerry, D., Schreiber, A.D., Shaw, J.M., Koch, P., and Cooper, R.A., 1977, A randomized clinical trial of granulocyte transfusions for infection in acute leukemia, N. Eng. J. Med. 296:706.
Bodey, G.P., Buckley, M., Sathe, Y.S., and Freireich, E.J., 1966, Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia, Ann. Int. Med. 64:328.
Catane, R., Kaufman, J., Mittelman, A., and Murphy, G.P., 1977, Attenuation of myelosuppression with lithium, N.Eng. J. Med. 297:452.
Charron, D., Barrett, A.J., Faille, A., Alby, N., Schmitt, T., and Degos, L., 1977, Lithium in acute myeloid leukemia, Lancet 1:1307.
Greco, F.A. and Brereton, H.D., 1977, Effect of lithium carbonate on the neutropenia caused by chemotherapy: a preliminary clinical trial, Oncology 34:154.
Gupta, R.C., Robinson, W.A., and Smyth, C.J., 1975, Efficacy of lithium in rheumatoid arthritis with granulocytopenia, Arthritis Rheum., 18:179.
Harker, W.G., Rothstein, G., Clarkson, D., Athens, J.W., and Macfarlane, J.L., 1977, Enhancement of colony stimulating activity production by lithium, Blood 49:263.
Herzig, R.H., Herzig, G.P., Graw, R.G., Bull, M.I., and Ray, K.K., 1977, Successful granulocyte transfusion therapy for gram-negative septicemia, N. Eng. J. Med. 296:701.
Joyce, R.A. and Chervenick, P.A., 1975, Effect of lithium on the release of colony stimulating activity (CSA) from blood leukocytes, Proc. Am. Soc. Hematol. 18:126.
Metcalf, D., Moore, M.A.S., Sheridan, J.W., and Spitzer, G., 1974, Responsiveness of human granulocytic leukemic cells to colony-stimulating factor, Blood 43:847.
Rothstein, G., Clarkson, D., Larsen, W., Grosser, B.I., and Athens, J.W., 1978, Effect of lithium on neutrophil mass and production, N. Eng. J. Med. 298:178.
Stein, R.S., Beaman, C., Ali, M.Y., Hansen, R., Jenkins, D.D., and Jume’an, H.G., 1977, Lithium carbonate attenuation of chemotherapy induced neutropenia, N. Eng. J. Med. 297:430.
Stein, R.S., Flexner, J.M., and Graber, S.E., 1978a, Lithium and granulocytopenia during induction therapy of acute myelogenous leukemia, Blood 52:277 (Supplement 1).
Stein, R.S., Hanson, G., Koethe, S., and Hansen, R., 1978b, Lithium induced granulocytosis, Ann. Int. Med. 88:809.
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© 1980 Plenum Press, New York
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Stein, R.S., Flexner, J.H., Graber, S.E. (1980). Lithium and Granulocytopenia During Induction Therapy of Acute Myelogenous Leukemia: Update of an Ongoing Trial. In: Rossof, A.H., Robinson, W.A. (eds) Lithium Effects on Granulopoiesis and Immune Function. Advances in Experimental Medicine and Biology, vol 127. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0259-0_14
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DOI: https://doi.org/10.1007/978-1-4757-0259-0_14
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