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Outer Membrane Proteins: Old and New

  • Chapter
Microbial Surface Components and Toxins in Relation to Pathogenesis

Part of the book series: Federation of European Microbiological Societies Symposium Series ((FEMS,volume 51))

Abstract

The outer membrane of Escherichia coli has been studied extensively for almost two decades and much is now known about the composition, structure, function, immunology, biosynthesis and regulation of the proteins which contribute to this outer protective layer (for reviews see refs 1–10). It is known to contain a number of major protein species, several of which e.g. the OmpF, OmpC, PhoE, LamB, Tsx proteins and Protein K are porins involved in the passive accumulation of small hydrophilic solutes. Others, like the iron-regulated outer membrane proteins (the fepA, fhuA, fhuE and fecA gene products) and the vitamin Bi2 receptor (the BtuB protein) are involved in the TonB-dependent uptake of more specific solutes (11–13). Other major proteins appear to play a structural role for the cell envelope. Falling into this category are proteins such as the Braun lipoprotein (the Lpp protein), peptidoglycan-associated lipoprotein (PAL) and the ompA gene product. Several other minor or less well characterized proteins, such as phospholipase A, the OmpT protein (a trypsin-like protease), signal peptidase, the tolC gene product (possibly involved in protein processing). Protein III, and an 83-kilodalton (kDa) iron regulated protein have also been identified (2, 4, 11).

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Author information

Author notes

  1. Patrick Caffrey

    Present address: Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK

  2. Lars-Goran Josefsson

    Present address: Department of Cell Research, Swedish Agricultural University, S-751 24, Uppsala, Sweden

Authors and Affiliations

  1. Department of Microbiology, Moyne Institute, Trinity College, Dublin, Ireland

    Peter Owen, Patrick Caffrey, Lars-Goran Josefsson & Mary Meehan

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  1. Peter Owen
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  2. Patrick Caffrey
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Editors and Affiliations

  1. Tel Aviv University, Tel Aviv, Israel

    Eliora Z. Ron

  2. The Hebrew University-Hadassah Medical School, Jerusalem, Israel

    Shlomo Rottem

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Owen, P., Caffrey, P., Josefsson, LG., Meehan, M. (1991). Outer Membrane Proteins: Old and New. In: Ron, E.Z., Rottem, S. (eds) Microbial Surface Components and Toxins in Relation to Pathogenesis. Federation of European Microbiological Societies Symposium Series, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8995-8_15

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