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Alterations of Synaptic Ultrastructure Induced by Hippocampal Kindling

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Kindling 4

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 37))

Abstract

Kindling, first discovered by the late Graham Goddard1, is widely regarded as a dramatic, reliable and robust form of neural plasticity2–6. One of the most remarkable features of kindling is that it induces a virtually permanent change in brain function. Synaptic responsiveness of the circuit stimulated during kindling undergoes an augmentation which persists, without further reinforcement, for many months5–9. This exceptionally enduring enhancement of synaptic efficacy caused by kindling and the dependence of the process on protein synthesis10,11 and axonal transport12,13 imply an underlying structural modification of the synapse itself.

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Author information

Authors and Affiliations

  1. Department of Cell Biology and Anatomy, Northwestern University Medical School, Chicago, IL, 60611, USA

    Yuri Geinisman

  2. Departments of Neurological Sciences, Rush Medical College, Chicago, IL, 60612, USA

    Frank Morrell & Leyla deToledo-Morrell

  3. Departments of Psychology, Rush Medical College, Chicago, IL, 60612, USA

    Leyla deToledo-Morrell

Authors
  1. Yuri Geinisman
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  2. Frank Morrell
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  3. Leyla deToledo-Morrell
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Editor information

Editors and Affiliations

  1. Neurosciences and Neurology, University of British Columbia, Vancouver, British Columbia, Canada

    Juhn A. Wada

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© 1990 Plenum Press, New York

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Geinisman, Y., Morrell, F., deToledo-Morrell, L. (1990). Alterations of Synaptic Ultrastructure Induced by Hippocampal Kindling. In: Wada, J.A. (eds) Kindling 4. Advances in Behavioral Biology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5796-4_7

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  • DOI: https://doi.org/10.1007/978-1-4684-5796-4_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5798-8

  • Online ISBN: 978-1-4684-5796-4

  • eBook Packages: Springer Book Archive

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